Effects of weight loss, induced by gastric bypass surgery, on HDL remodeling in obese women

Asztalos, Bela F.; Swarbrick, Michael M.; Schaefer, Ernst J.; Dallal, Gerard E.; Horvath, Katalin V.; Ai, Masumi; Stanhope, Kimber L.; Austrheim-Smith, Iselin; Wolfe, Bruce M.; Ali, Mohamed R.; Havel, Peter J.

doi:10.1194/jlr.p900015

Cited by 54 publications

(47 citation statements)

References 42 publications

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“…However, an increase in its activity is considered proatherogenic because it can reduce HDL concentrations and influence adipocyte morphology (16,32,33). Therefore, our results suggest that these overweight and obese children were exposed to a similar CETP-mediated proatherogenic phenotype to that of overweight and obese adults, which may be negated by weight loss as documented in adults (34).…”

Section: Discussionmentioning

confidence: 69%

High-density lipoprotein subfractions display proatherogenic properties in overweight and obese children

et al. 2013

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Background:In adults, obesity-driven inflammation can lead to increased cardiovascular disease (CVD). However, information regarding childhood obesity and its inflammatory sequelae is less well defined. Serum amyloid-A (SAA) is an inflammatory molecule that rapidly associates with highdensity lipoproteins (HDLs) and renders them dysfunctional. Therefore, SAA may be a useful biomarker to identify increased CVD potential in overweight and obese children. Methods: Young Hearts 2000 is a cross-sectional cohort study in which 92 children who were obese were matched for age and sex with 92 overweight and 92 lean children. HDL 2 and HDL 3 (HDL 2&3 ) were isolated from plasma by a three-step rapid-ultracentrifugation procedure. SAA was measured in serum and HDL 2&3 by an enzyme-linked immunosorbent assay procedure, and the activities of cholesterol ester transfer protein (CETP) and lecithin cholesteryl acyltransferase (LCAT) were measured by fluorimetric assays. results: Trends across the groups indicated that SAA increased in serum and HDL 2&3 as BMI increased, as did HDL 2 -CETP and HDL 2 -LCAT activities. conclusion: These results have provided evidence that overweight and obese children are exposed to an inflammatory milieu that impacts the antiatherogenic properties of HDL and that could increase CVD risk. This supports the concept that it is important to target childhood obesity to help minimize future cardiovascular events.

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Section: Discussionmentioning

confidence: 69%

High-density lipoprotein subfractions display proatherogenic properties in overweight and obese children

et al. 2013

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“…Large ␣-1 particles increase with weight loss, niacin, certain statins (atorvastatin, rosuvastatin), and CETP inhibitors (52)(53)(54)(55)(56)(57). Increasing the concentrations of apo AI in ␣-1 HDL to Ͼ200 mg/L (0.52 mmol/L) with a simvastatin/niacin combination has been associated with lack of progression and in some individuals with regression of coronary atherosclerosis (51 ).…”

Section: -D Gel Electrophoresismentioning

confidence: 99%

HDL Measures, Particle Heterogeneity, Proposed Nomenclature, and Relation to Atherosclerotic Cardiovascular Events

et al. 2011

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BACKGROUND A growing body of evidence from epidemiological data, animal studies, and clinical trials supports HDL as the next target to reduce residual cardiovascular risk in statin-treated, high-risk patients. For more than 3 decades, HDL cholesterol has been employed as the principal clinical measure of HDL and cardiovascular risk associated with low HDL-cholesterol concentrations. The physicochemical and functional heterogeneity of HDL present important challenges to investigators in the cardiovascular field who are seeking to identify more effective laboratory and clinical methods to develop a measurement method to quantify HDL that has predictive value in assessing cardiovascular risk. CONTENT In this report, we critically evaluate the diverse physical and chemical methods that have been employed to characterize plasma HDL. To facilitate future characterization of HDL subfractions, we propose the development of a new nomenclature based on physical properties for the subfractions of HDL that includes very large HDL particles (VL-HDL), large HDL particles (L-HDL), medium HDL particles (M-HDL), small HDL particles (S-HDL), and very-small HDL particles (VS-HDL). This nomenclature also includes an entry for the pre-β-1 HDL subclass that participates in macrophage cholesterol efflux. SUMMARY We anticipate that adoption of a uniform nomenclature system for HDL subfractions that integrates terminology from several methods will enhance our ability not only to compare findings with different approaches for HDL fractionation, but also to assess the clinical effects of different agents that modulate HDL particle structure, metabolism, and function, and in turn, cardiovascular risk prediction within these HDL subfractions.

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“…In contrast of other lipid fractions the effects of gastric bypass on HDL-C showed different and conflicting results between genders and age groups. Some authors suggest that the response of HDL-C is represented graphically by a "U" curve-shaped, with a decrease in the first month and a gradual increase after 6 months of surgery (3,23) . In fact, the average values found in our study groups suggest the formation of this curve, but in a discreet manner and with values without statistical change.…”

Section: Discussionmentioning

confidence: 99%

AGE AND GENDER MAY INFLUENCE THE RESULTS OF ROUX-EN-Y GASTRIC BYPASS? Metabolic syndrome parameters

Andrade-Silva

Caranti

Sallet³

et al. 2014

Arq. Gastroenterol.

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-Context -Severe obesity affects the body favoring the development of serious diseases, including hypertension, diabetes mellitus, atherosclerosis and non alcoholic fatty liver disease. Bariatric procedures increased in Brazil in the last decade. Objectives -The purpose of this study was to verify if gender and age in date of procedure resulted significant differences in metabolic syndrome parameters after surgery. Methods -The study involved 205 medical records of adult patients undergoing Roux-en-Y gastric bypass, stratified by gender and age groups and followed one year by a multidisciplinary team. Results -It was observed significant decrease in body mass index, fasting glucose and insulin at all ages and both genders. Lipid profile showed significant improvements except high density lipoprotein cholesterol. Ectopic fat in the liver has decreased after 6 months in patients classified with steatosis at baseline. Patients classified as hypertensive blood pressure levels decreased 6 months after surgical intervention. Conclusion -Roux-en-Y gastric bypass proved to be an important tool in remission of metabolic syndrome parameters. The reduction of body mass accompanied to decrease in insulin resistance resulted in lower prevalence of comorbidities associated with obesity. The benefits were similar and extended both genders and all age groups between 18 and 65 years old. HEADINGS -Bariatric surgery. Metabolic syndrome X. Roux-en-Y anastomosis. Fatty liver.

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Effects of weight loss, induced by gastric bypass surgery, on HDL remodeling in obese women

Cited by 54 publications

References 42 publications

High-density lipoprotein subfractions display proatherogenic properties in overweight and obese children

High-density lipoprotein subfractions display proatherogenic properties in overweight and obese children

HDL Measures, Particle Heterogeneity, Proposed Nomenclature, and Relation to Atherosclerotic Cardiovascular Events

AGE AND GENDER MAY INFLUENCE THE RESULTS OF ROUX-EN-Y GASTRIC BYPASS? Metabolic syndrome parameters

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