Effects of Weight Loss on Enzymatic Antioxidants and its Correlation amongst Overweight Women

Abstract

The present study is a clinical trial carried out to evaluate the effects of weight loss on enzymatic antioxidants and their correlations. Methods: Thirty obese women, between the ages of 19-50, were included in this study. A low calorie diet with a 500-1000calorie deficit was recommended with the aim of 10% weight loss. To measure nutrient intake, general questionnaires and 24hour recall forms were used three days prior and after intervention. A 10ml blood sample was taken from each subject before and after intervention for the measurement of enzymatic antioxidants in the red blood cells. Results: Weight loss caused a significant increase (p<0.01) in the mean glutathione reductase (GR) and catalase (CAT). No statistically significant change occurred in the mean values of superoxide dismutase (SOD) or glutathione peroxidase (GPX). Based on the Pearson's correlation coefficient between the dependent variables (GPX, CAT, GR, SOD) of the participants after intervention, there was a meaningful correlation between the dependent variables SOD with GPX at P<0.001 and r=0.618 and between SOD with CAT at P<0.05 and r=0.424. Also between GPX with CAT at P=0.003 and r=0.527 and between CAT with GR at P<0.05 and r=0.366 there is a meaningful correlation after intervention. Conclusion: A 10% reduction in body weight can have a significant effect on increasing the levels of enzymatic antioxidants in obese women. There is the possibility of greater increase in enzymatic antioxidants and their correlation with weight loss and the reduction of BMI to a normal range in obese people.