Effects Of Weight Reduction In Obese People With Severe Asthma: Randomised Controlled Study

Dias-Júnior, Sérvulo Azevedo; Stelmach, Rafaël; Pinto, Rodrigo Ambar; Reis, Monica; Halpern, Alfredo; Cukier, Alberto

doi:10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4315

Cited by 2 publications

(3 citation statements)

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“…Interventions were limited to dietary manipulation in three studies (29)(30)(31) and bariatric surgery in four (32)(33)(34)(35). In the randomized controlled trial by Stenius-Aarniala and coworkers, the treatment group took part in a weight reduction program that included 12 group sessions and lasted 14 weeks, including 8 weeks in which participants took a very-low-energy dietary preparation with 1760 kJ of energy and daily allowances of all essential nutrients (29).…”

Section: Weight Loss Interventionsmentioning

confidence: 99%

“…In the Dias-Junior et al (31) study, the authors did not report the comparison between study arms but differences between subjects who achieved the targeted 10% weight loss independently of the intervention. With this significant selection bias, the observational controlled report on the effect of weight loss showed a significant reduction in symptom scores as assessed by the Asthma Control Questionnaire (31).…”

Section: Asthma Control-related Measuresmentioning

confidence: 99%

“…With this significant selection bias, the observational controlled report on the effect of weight loss showed a significant reduction in symptom scores as assessed by the Asthma Control Questionnaire (31).…”

Section: Asthma Control-related Measuresmentioning

confidence: 99%

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Weight loss interventions in asthma: EAACI Evidence‐Based Clinical Practice Guideline (Part I)

Moreira

Bonini

García-Larsen

et al. 2013

Allergy

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Background: Asthma and obesity are chronic multifactorial conditions that are associated with gene-environment interaction and immune function. Although the data are not fully consistent, it seems that obesity increases the risk of asthma and compromises asthma control. Objective: To investigate the impact that weight changes have on asthma. Methods: We carried out a systematic review of three large biomedical databases. Studies were scrutinized and critically appraised according to agreed exclusion and inclusion criteria. Quality assessment of eligible papers was conducted using the GRADE method. Meta-analyses of comparable studies were carried out. Results: Thirty studies met the eligibility criteria of the review. Interventions were limited to dietary manipulation in three studies, one of which also used anti-obesity drugs, and bariatric surgery in four. All the other studies reported observational data. Becoming obese increased the odds for incident asthma by 1.82 (95% CI 1.47, 2.25) in adults and 1.98 (95% CI 0.71, 5.52) in children. Weight loss was associated with significant improvement in mean scores for symptoms, rescue medication score, and asthma exacerbations in the only randomized controlled trial. Similarly, evidence gathered from observational studies, with follow-up ranging between 8 weeks to 1 year, and from changes 1 year after bariatric surgery showed improvements in all asthma control-related outcomes. Changes in lung function were reported in one randomized controlled and eight observational studies of asthmatic subjects, with conflicting results. Either improvement after weight loss, decline with weight gain, or no effects at all were reported. Changes in airway inflammation and responsiveness were reported only by observational studies. Conclusion: Weight increases above the obesity threshold significantly increase the risk of asthma. The available studies show weak evidence of benefits from weight reduction on asthma outcomes.

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