Effects of Wen Dan Tang on insomnia-related anxiety and levels of the brain-gut peptide Ghrelin

Wang, Liye; Song, Yuehan; Li, Feng; Liu, Yan; Ma, Jie; Mao, Meng; Wu, Fengzhi; Wu, Ying; Li, Sinai; Guan, Binghe; Liu, Xiaolan

doi:10.4103/1673-5374.125351

Cited by 33 publications

(15 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, insomnia patients typically suffer from comorbid emotional issues including depression, anxiety, nervousness, and irritability [ 3 ]. In fact, 54% of primary insomnia patients have a coexisting emotional disorder [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Suan Zao Ren Tangin Combination withZhi Zi Chi Tangas a Treatment Protocol for Insomniacs with Anxiety: A Randomized Parallel-Controlled Trial

Zhang

Liu

et al. 2015

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Insomnia is a serious worldwide health problem that is often comorbid with anxiety. The purpose of the present study was to evaluate the efficacy of a Chinese formula containing Suan Zao Ren Tang (SZRT) and Zhi Zi Chi Tang (ZZCT; SZR-ZZC) for improving sleep quality and anxiety states with four indices of Polysomnography (PSG), the Insomnia Severity Index (ISI), the Pittsburgh Sleep Quality Index (PSQI), and the Self Rating Anxiety Scale (SAS). Methods. A randomized, parallel-controlled trial compared SZR-ZZC to lorazepam tablet in insomniacs with anxiety. Patients were randomized to the SZR-ZZC treatment group (n = 60) and the lorazepam tablet treatment group (n = 59). Results. SZR-ZZC significantly improved scores on all four treatment indices. Compared with lorazepam, treatment with SZR-ZZC resulted in a significant reduction in the ISI (P = 0.029), the PSQI (P = 0.017), and wake after sleep onset (WASO; P = 0.008) scores and improved sleep architecture (P = 0.000–0.003) after a 4-week treatment period. Only one subject in the SZR-ZZC group experienced adverse side effects. Conclusion. Treatment with SZR-ZZC for 4 weeks appears to be a relatively safe and effective complementary therapeutic option when aiming to improve sleep quality and anxiety in insomniacs with anxiety.

show abstract

Section: Introductionmentioning

confidence: 99%

Suan Zao Ren Tangin Combination withZhi Zi Chi Tangas a Treatment Protocol for Insomniacs with Anxiety: A Randomized Parallel-Controlled Trial

Zhang

Liu

et al. 2015

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…One study indicated that Wen-Dan-Tang (WDT), a major component of CGKM, significantly reduced anxiety and prevented ghrelin level reduction due to sleep deprivation in the study subject, especially in the hypothalamus, thereby suggesting that the mechanism of WDT may correspond to changes in the brain–gut axis. 18 CSS has antidepressant-like effects and was mediated by reversing the stress-induced disruption of ERK5 expressions in the hippocampi of rats. 19 CGKM tables were composed of Chai-Hu-Jia-Long-Gu-Mu-Li-Tang, Xiao-Chaihu-Tang and WDT.…”

Section: Discussionmentioning

confidence: 96%

Traditional Chinese medicine-facilitated treatments may relieve anxiety symptoms during drug switching from methadone to buprenorphine/naloxone for treating opioid dependence

Wei

Yeh

et al. 2017

BMJ Case Reports

View full text Add to dashboard Cite

This study investigated a 51-year-old married man with a history of heroin dependence who underwent methadone maintenance treatment for 7 years. He received traditional Chinese medicine (TCM)-facilitated treatments and switched from methadone to buprenorphine/naloxone. Strong anxiety symptoms were observed during the initial stage; therefore, we prescribed a combination of Chaihu-Shugan-San, Zhi Bai Di Huang and Chin-Gin-Kuan-Ming decoction as the major herbal synergic regimen to relieve the symptoms of opioid withdrawal, anxiety and insomnia. During the treatment course, no precipitating withdrawal syndromes were noted, and the subject was gradually relieved of his anxiety symptoms through continual TCM treatments. In conclusion, TCM is effective in facilitating the switch from methadone to buprenorphine/naloxone and relieving anxiety symptoms. Therefore, focus on TCM-facilitated treatments for heroin dependence should be increased.

show abstract

“…Previous studies have shown that different Chinese herbal compounds play different roles in the care of patients with prostate cancer. For example, Wen-Dan-Tang can effectively alleviate the anxiety associated with insomnia by regulating the performance of the ghrelin receptor in the hypothalamus and the concentration of leptin in the brain [19,20]. Chai-Hu-Jia-Long-Gu-Mu-Li-Tang can reduce the symptoms of hypogonadism caused by castration therapy, including sexual dysfunction, hot flashes, night sweats, and insomnia [21].…”

Section: Discussionmentioning

confidence: 99%

Spirit-Quieting Traditional Chinese Medicine May Improve Survival in Prostate Cancer Patients with Depression

Lin

Hsu

et al. 2019

JCM

View full text Add to dashboard Cite

Depression is associated with higher mortality in prostate cancer. However, whether traditional Chinese medicine (TCM) for depression improves outcomes in patients with prostate cancer is unclear. This retrospective cohort study evaluated the association between TCM for depression and mortality in patients with prostate cancer. During the period 1998–2012, a total of 248 prostate cancer patients in Taiwan with depression were enrolled and divided into three groups: TCM for depression (n = 81, 32.7%), TCM for other purposes (n = 53, 21.3%), and no TCM (n = 114, 46.0%). During a median follow-up of 6.2 years, 12 (14.8%), 13 (24.5%), and 36 (31.6%) deaths occurred in the TCM for depression, TCM for other purposes, and no TCM groups, respectively. After adjusting age at diagnosis, urbanization, insured amount, comorbidity disease, and prostate cancer type, TCM for depression was associated with a significantly lower risk of overall mortality based on a multivariate-adjusted Cox proportional-hazards model (hazard ratio 0.42, 95% confidence interval: 0.21–0.85, p = 0.02) and Kaplan–Meier survival curve (log-rank test, p = 0.0055) compared to no TCM. In conclusion, TCM for depression may have a positive association with the survival of prostate cancer patients with depression.

show abstract

Effects of Wen Dan Tang on insomnia-related anxiety and levels of the brain-gut peptide Ghrelin

Cited by 33 publications

References 37 publications

Suan Zao Ren Tangin Combination withZhi Zi Chi Tangas a Treatment Protocol for Insomniacs with Anxiety: A Randomized Parallel-Controlled Trial

Suan Zao Ren Tangin Combination withZhi Zi Chi Tangas a Treatment Protocol for Insomniacs with Anxiety: A Randomized Parallel-Controlled Trial

Traditional Chinese medicine-facilitated treatments may relieve anxiety symptoms during drug switching from methadone to buprenorphine/naloxone for treating opioid dependence

Spirit-Quieting Traditional Chinese Medicine May Improve Survival in Prostate Cancer Patients with Depression

Contact Info

Product

Resources

About