Effects of whole body heat stress on sublingual microcirculation in healthy humans

Pranskūnas, Andrius; Pranskūnienė, Živilė; Milieškaitė, Eglė; Daniusevičiūtė, Laura; Kudrevičienė, Aušrelė; Vitkauskienė, Astra; Skurvydas, Albertas; Brazaitis, Marius

doi:10.1007/s00421-014-2999-2

Cited by 24 publications

(14 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to those hormonal thermoregulatory responses, estrogen has also been shown to stimulate the secretion of prolactin, an indirect marker of central serotonergic and dopaminergic activity in the brain that is implicated in the thermoregulatory control of body temperature, changes in behavior, motor control, motivation, and immune system regulation [36,37]. Thus, consistent with previous research [10,38], our results show a fivefold increase in severe WBHinduced prolactin response in young adult women. Taken together, the findings of our study suggest that severe WBH per se is a sufficient stimulus to induce the expression of ovarian hormones and that this may have therapeutic potential for young adult women in, for example, estrogen treatment and overall women's health.…”

Section: Discussionsupporting

confidence: 91%

Effects of severe whole-body hyperthermia on ovarian hormone and extracellular Hsp72 responses in young adult women

Brazaitis

Eimantas

Baranauskienė

et al. 2019

International Journal of Hyperthermia

Self Cite

View full text Add to dashboard Cite

Background: Although acute thermal stress appears to be one of the most effective stressors that increase the intra-and extracellular concentrations of heat shock protein 72 (Hsp72), 17b-estradiol has been shown to inhibit heat-induced Hsp72 expression. Materials and Methods: To determine whether severe whole-body hyperthermia (increase in rectal temperature up to 39.5 C) induced by lower-body heating is a sufficient stimulus to modulate hormonal (17b-estradiol, progesterone, prolactin, epinephrine, and norepinephrine) and extracellular Hsp72 responses, we investigated young adult women (21 ± 1 yr). Results and Conclusions: In the present study, we show that a severe whole-body hyperthermia (increase in rectal temperature of approximately 2.6 C and heart rate of approximately 80 bpm from baseline) was sufficient to increase 17b-estradiol, progesterone, and prolactin and catecholamine norepinephrine concentration. Moreover, we show that the concentration of extracellular Hsp72 and catecholamine epinephrine were not affected by severe whole-body hyperthermia in young adult women. From the functional point of view, expression of ovarian hormones induced by passive heat stress may have therapeutic potential for young adult women in, for example, estrogen treatment and overall women's health.

show abstract

Section: Discussionsupporting

confidence: 91%

Effects of severe whole-body hyperthermia on ovarian hormone and extracellular Hsp72 responses in young adult women

Brazaitis

Eimantas

Baranauskienė

et al. 2019

International Journal of Hyperthermia

Self Cite

View full text Add to dashboard Cite

show abstract

“…We calculated the microvascular flow index (MFI) as the sum of each quadrant score divided by the number of quadrants in which the vessel type was visible. The final MFI was averaged over a minimum of 12 quadrants (three regions, four quadrants per region) derived from the overall flow impressions of all vessels with a particular range of diameters in a given quadrant [ 16 , 17 ].…”

Section: Methodsmentioning

confidence: 99%

“…We analyzed these data using parametric tests. A one-way repeated-measures ANOVA model with a Bonferroni correction was used to compare multiple sets of related values [ 17 ]. For the subgroup statistical analysis, we performed nonparametric tests.…”

Section: Methodsmentioning

confidence: 99%

Time Evolution of Sublingual Microcirculatory Changes in Recreational Marathon Runners

Pranskūnas

Arstikyte

Pranskūnienė

et al. 2017

BioMed Research International

Self Cite

View full text Add to dashboard Cite

We aimed to evaluate changes in sublingual microcirculation induced by a marathon race. Thirteen healthy male controls and 13 male marathon runners volunteered for the study. We performed sublingual microcirculation, using a Cytocam-IDF device (Braedius Medical, Huizen, Netherlands), and systemic hemodynamic measurements four times: 24 hours prior to their participation in the Kaunas Marathon (distance: 41.2 km), directly after finishing the marathon, 24 hours after the marathon, and one week after the marathon. The marathon runners exhibited a higher functional capillary density (FCD) and total vascular density of small vessels at the first visit compared with the controls. Overall, we did not find any changes in sublingual microcirculation of the marathon runners at any of the other visits. However, in a subgroup of marathon runners with a decreased FCD compared to the subgroup with increased FCD, the subgroup with decreased FCD had shorter running time (190.37 ± 30.2 versus 221.80 ± 23.4 min, p = 0.045), ingested less fluids (907 ± 615 versus 1950 ± 488 mL, p = 0.007) during the race, and lost much more weight (−2.4 ± 1.3 versus −1.0 ± 0.8 kg, p = 0.041). Recreational marathon running is not associated with an alteration of sublingual microcirculation. However, faster running and dehydration may be crucial for further impairing microcirculation.

show abstract

“…Aiming at evading the effect of dietinduced thermogenesis, the subjects did not eat from 12 h before the start of the experiment until it ended. To standardize the condition of hydration and the feeling of thirst, subjects were allowed to drink still water if they wanted until 60 min before the first body mass measurement [2,10,36,37].…”

Section: Familiarization Sessionmentioning

confidence: 99%

Motor performance is preserved in healthy aged adults following severe whole-body hyperthermia

Brazaitis

Paulauskas

Eimantas

et al. 2018

International Journal of Hyperthermia

Self Cite

View full text Add to dashboard Cite

Healthy aging is associated with a progressive decline in motor performance and thermoregulatory efficiency. Functional consequences of severe whole-body hyperthermia on neurophysiological functions in healthy aged men have not been investigated. To determine whether severe whole-body hyperthermia (increase in rectal temperature of about 2.5 C) induced by lower-body heating in older men (64-80 years, n ¼ 9) would suppress excitability of reflexes, voluntarily and electrically induced ankle plantar flexor contractile properties were compared with those in young men (19-21 years, n ¼ 11). Though no aging effect on hyperthermia-induced reflex amplitudes was observed, a decrease in maximal H-reflex and V-wave latencies was found to be greater in older than in young men. In older men, lower-body heating was accompanied by a significant increase in twitch and tetani test torque in parallel with a greater decrease in muscle contraction time. There was no temperaturedepended aging effect on the voluntary activation and maximal voluntary torque production. Despite delayed and weakened thermoregulation and age-related decline in neuromuscular function, motor performance in whole-body severe hyperthermia is apparently preserved in healthy aging. ARTICLE HISTORY

show abstract

Effects of whole body heat stress on sublingual microcirculation in healthy humans

Abstract: Whole body heat stress increases sublingual functional capillary density, oxygen consumption, and cardiac output.

Cited by 24 publications

References 44 publications

Effects of severe whole-body hyperthermia on ovarian hormone and extracellular Hsp72 responses in young adult women

Effects of severe whole-body hyperthermia on ovarian hormone and extracellular Hsp72 responses in young adult women

Time Evolution of Sublingual Microcirculatory Changes in Recreational Marathon Runners

Motor performance is preserved in healthy aged adults following severe whole-body hyperthermia

Contact Info

Product

Resources

About