Effects of whole body vibration in patients with chronic obstructive pulmonary disease – A randomized controlled trial

Gloeckl, Rainer; Heinzelmann, Inga; Baeuerle, Sandra; Damm, Eva; Schwedhelm, Anna-Lena; Diril, Merve; Buhrow, David; Jerrentrup, Andreas; Kenn, Klaus

doi:10.1016/j.rmed.2011.10.021

Cited by 106 publications

(118 citation statements)

References 41 publications

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“…The 3-week exercise training program employed in this study was a component of a comprehensive, multidisciplinary, inpatient PR program [13]. The exercise training program consisted of daily endurance training on a cycle ergometer [60% of peak work rate (PWR)] and resistance training for large muscle groups (3 sets with 20 repetitions).…”

Section: Methodsmentioning

confidence: 99%

Different Training-Induced Skeletal Muscle Adaptations in COPD Patients with and without Alpha-1 Antitrypsin Deficiency

et al. 2016

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Background: Pulmonary rehabilitation (PR) improves oxidative capacity of peripheral muscles in patients with chronic obstructive pulmonary disease (COPD). The exercise-induced oxidative skeletal muscle adaptation in COPD patients with inherited alpha-1 antitrypsin deficiency (A1ATD) has not been studied. Objectives: To compare PR effects on skeletal muscle adaptation in COPD patients with and without A1ATD. Methods: Nine COPD patients with A1ATD (genotype PiZZ, 6 receiving A1AT augmentation therapy), and 10 ‘usual' COPD patients (genotype PiMM) performed an incremental cycling test and underwent musculus vastus lateralis biopsies before and after a 3-week PR program including exercise training. Results: PiZZ and PiMM patients improved peak work rate following PR (+9 ± 11 W, p < 0.05, and +18 ± 9 W, p < 0.001, between-group difference p < 0.05). PiMM patients increased fibre type I (+8.1%), reduced fibre type IIA (-2.1%) and hybrid fibre type IIA/IIX proportion (-3.9%). Following PR, PiMM patients also raised mitochondrial signalling proteins PGC-1α (4.5-fold), and TFAM (6.4-fold). PiZZ patients had no change in fibre type I but showed a shift of type IIA/IIX (-8.8%) towards fibre type IIA distribution (+8.9%). The capillary to fibre ratio increased by 28% (p < 0.05) in PiZZ, whereas no change was observed in PiMM patients. Linear regression analysis revealed that diffusion capacity and A1AT therapy are predictor variables for myofibre type I response to PR (r² = 0.684, p < 0.01). Conclusions: Following a 3-week PR with comparable training modalities, PiMM but not PiZZ patients increased the oxidative myofibre type I proportion. This skeletal muscle adaptation pattern suggests better improvement of exercise capacity in PiMM than in PiZZ patients with COPD.

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Section: Methodsmentioning

confidence: 99%

Different Training-Induced Skeletal Muscle Adaptations in COPD Patients with and without Alpha-1 Antitrypsin Deficiency

et al. 2016

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“…New training modalities besides conventional exercise methods, such as neuromuscular electrical muscle stimulation [49,50], inspiratory muscle training [51,52], whole-body vibration training [53], or noninvasive ventilation [54,55], have been shown to be beneficial in patients with advanced COPD. It could be hypothesized that these therapeutic interventions may also be useful in IPF.…”

Section: Unmet Needs For An Ipf-specific Pr Approachmentioning

confidence: 99%

Pulmonary Rehabilitation in Patients with Idiopathic Pulmonary Fibrosis - A Review

Kenn

Gloeckl

Behr³

2013

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Among the various types of interstitial lung diseases, idiopathic pulmonary fibrosis (IPF) is the most common disorder and has a poor prognosis and a limited response to pharmacological treatment. In patients with IPF, functional exercise tolerance and quality of life have been shown to be significantly decreased. Current IPF guidelines suggest only a weak recommendation for pulmonary rehabilitation (PR). However, PR is regarded as a reasonable choice for the majority of patients with IPF. This review will summarize all of the available studies that have investigated the effects of PR in patients with IPF so far. Although only a small number of studies have been published to date, most studies have found significant short-term improvements in functional exercise capacity, quality of life, and level of perceived dyspnea. Long-term improvements or maintenance strategies of PR in IPF patients have not been adequately investigated yet. Up to now there is still no sufficient evidence for the recommendation of PR in IPF. However, physical training seems to be the major component of all PR programs. The current review will discuss potential exercise training regimens for patients with IPF and suggest additional useful modalities of a specific multidisciplinary PR program for IPF patients. Based on the current literature and our own experience, this article will try to highlight the importance of PR as an additional, beneficial therapeutic option for patients with IPF.

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“…Pulmonary rehabilitation improves exercise performance, dyspnea, and quality of life, reduces the effects of acute exacerbations and prolongs the interval between exacerbations [5,6]. Current guidelines recommend pulmonary rehabilitation for all stages of COPD but do not explicitly recommend it during an acute exacerbation [1].…”

Section: Introductionmentioning

confidence: 99%

“…Whole body vibration (WBV) is a novel exercise training modality performed on a vibrating platform that moves in sinusoidal oscillations, during which static and dynamic exercises can be performed [6]. A randomized clinical trial has demonstrated greater improvements in a number of exercise tests in the group of COPD patients (GOLD stages III and IV) trained on the WBV platform compared to a group that was conventionally trained [6].…”

Section: Introductionmentioning

confidence: 99%

Benefits of whole body vibration training in patients hospitalised for COPD exacerbations - a randomized clinical trial

et al. 2014

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BackgroundPatients with stable COPD show improvements in exercise capacity and muscular function after the application of whole body vibration. We aimed to evaluate whether this modality added to conventional physiotherapy in exacerbated hospitalised COPD patients would be safe and would improve exercise capacity and quality of life.Methods49 hospitalised exacerbated COPD patients were randomized (1:1) to undergo physiotherapy alone or physiotherapy with the addition of whole body vibration. The primary endpoint was the between-group difference of the 6-minute walking test (day of discharge – day of admission). Secondary assessments included chair rising test, quality of life, and serum marker analysis.ResultsWhole body vibration did not cause procedure-related adverse events. Compared to physiotherapy alone, it led to significantly stronger improvements in 6-minute walking test (95.55 ± 76.29 m vs. 6.13 ± 81.65 m; p = 0.007) and St. Georges Respiratory Questionnaire (-6.43 ± 14.25 vs. 5.59 ± 19.15, p = 0.049). Whole body vibration increased the expression of the transcription factor peroxisome proliferator receptor gamma coactivator-1-α and serum levels of irisin, while it decreased serum interleukin-8.ConclusionWhole body vibration during hospitalised exacerbations did not cause procedure-related adverse events and induced clinically significant benefits regarding exercise capacity and health-related quality of life that were associated with increased serum levels of irisin, a marker of muscle activity.Trial registrationGerman Clinical Trials Register DRKS00005979. Registered 17 March 2014.

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Effects of whole body vibration in patients with chronic obstructive pulmonary disease – A randomized controlled trial

Abstract: WBV training seems to be a promising new exercise modality for patients with COPD and may enhance the effects of a multidisciplinary rehabilitation program.

Cited by 106 publications

References 41 publications

Different Training-Induced Skeletal Muscle Adaptations in COPD Patients with and without Alpha-1 Antitrypsin Deficiency

Different Training-Induced Skeletal Muscle Adaptations in COPD Patients with and without Alpha-1 Antitrypsin Deficiency

Pulmonary Rehabilitation in Patients with Idiopathic Pulmonary Fibrosis - A Review

Benefits of whole body vibration training in patients hospitalised for COPD exacerbations - a randomized clinical trial

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