Effects of whole-body vibration on plasma sclerostin level in healthy women

Çidem, Muharrem; Karakoç, Yunus; Ekmekçi, Hakan; Küçük, Suat Hayri; Uludağ, Murat; Gün, Kerem; Karamehmetoglu, Safak Sahir; Karacan, İlhan

doi:10.3906/sag-1302-88

Cited by 10 publications

(17 citation statements)

References 31 publications

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“…The sclerostin index increases in accordance with the levels of sclerostin, which enters the systemic circulation from bony tissue with one session of WBV. However, the sclerostin index decreases when WBV is applied in consecutive sessions and with increasing intensity (20). Similar results were found in the present study.…”

Section: Effects Of Whole-body Vibration Onsupporting

confidence: 82%

“…Its expression in adult bone is regulated by mechanical strain (17)(18)(19). WBV can cause changes in plasma sclerostin levels in adult women (20). Plasma sclerostin levels indicate osteocyte activity (21).…”

Section: Methodsmentioning

confidence: 99%

“…Additionally, sclerostin expression is regulated by mechanical strain in adult bone, and plasma sclerostin levels increase after WBV (17)(18)(19)(20). High plasma sclerostin levels were reported to indicate an increase in osteocyte activity (21).…”

Section: Limitations Of This Studymentioning

confidence: 99%

“…In a previous study on healthy young adult women, we determined that the plasma sclerostin (SOST) levels peaked at the 10 th min after WBV (20). To standardise the change in plasma SOST levels occurring after vibration, the following formula was used: SVI SOST index = SOST level (10th minute after WBV) / SOST level (before WBV).…”

Section: Plasma Sclerostin Levelsmentioning

confidence: 99%

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A Randomized Trial on the Effect of Bone Tissue on Vibration-induced Muscle Strength Gain and Vibration-induced Reflex Muscle Activity

Çidem¹,

Karacan²,

Dıraçoğlu³

et al. 2014

Balkan Med J

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Whole-body vibration (WBV), as a method of exercise training, is becoming increasingly popular in physical therapy, rehabilitation, and professional sports, and is increasingly used in beauty and wellness applications due to its beneficial effects on the neuromusculoskeletal system. These benefits include improved strength, power, flexibility, jump height, and balance (1-4).However, little is known about the physiological mechanisms underlying the effects of WBV on muscular performance, although the presence of reflex muscle activity during WBV has been shown (4, 5). Tonic vibration reflex (TVR) is the most commonly cited mechanism to explain the effects of WBV on muscular performance, although there is no conclusive evidence that tonic vibration reflex (TVR) occurs (4-6). Studies have reported that direct vibration applied to a muscle or tendon stimulates muscle spindles, thereby causing a TVR to occur. As highlighted by these studies, muscle spindle Background: Whole-body vibration (WBV) induces reflex muscle activity and leads to increased muscle strength. However, little is known about the physiological mechanisms underlying the effects of whole-body vibration on muscular performance. Tonic vibration reflex is the most commonly cited mechanism to explain the effects of whole-body vibration on muscular performance, although there is no conclusive evidence that tonic vibration reflex occurs. The bone myoregulation reflex is another neurological mechanism used to explain the effects of vibration on muscular performance. Bone myoregulation reflex is defined as a reflex mechanism in which osteocytes exposed to cyclic mechanical loading induce muscle activity. Aims: The aim of this study was to assess whether bone tissue affected vibration-induced reflex muscle activity and vibration-induced muscle strength gain. Study Design: A prospective, randomised, controlled, double-blind, parallel-group clinical trial. Methods: Thirty-four participants were randomised into two groups. High-magnitude whole-body vibration was applied in the exercise group, whereas low-magnitude whole-body vibration exercises were applied in the control group throughout 20 sessions. Hip bone mineral density, isokinetic muscle strength, and plasma sclerostin levels were measured. The surface electromyography data were processed to obtain the Root Mean Squares, which were normalised by maximal voluntarily contraction. Results: In the exercise group, muscle strength increased in the right and left knee flexors (23.9%, p=0.004 and 27.5%, p<0.0001, respectively). However, no significant change was observed in the knee extensor muscle strength. There was no significant change in the knee muscle strength in the control group. The vibration-induced corrected Root Mean Squares of the semitendinosus muscle was decreased by 2.8 times (p=0.005) in the exercise group, whereas there was no change in the control group. Sclerostin index was decreased by 15.2% (p=0.031) in the exercise group and increased by 20.8% (p=0.028) in the control group. A change in th...

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Section: Effects Of Whole-body Vibration Onsupporting

confidence: 82%

Section: Methodsmentioning

confidence: 99%

Section: Limitations Of This Studymentioning

confidence: 99%

Section: Plasma Sclerostin Levelsmentioning

confidence: 99%

See 2 more Smart Citations

A Randomized Trial on the Effect of Bone Tissue on Vibration-induced Muscle Strength Gain and Vibration-induced Reflex Muscle Activity

Çidem¹,

Karacan²,

Dıraçoğlu³

et al. 2014

Balkan Med J

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“…Considering the indirect effects of the WBV exercises, besides the changes on the hormone concentration in the plasma (Bosco et al, 2000;Di Loreto et al, 2004;Goto and Takamatsu, 2005;Martin et al, 2009;Çidem et al, 2014;Huh et al, 2014), other biomarkers (Goto and Takamatsu, 2005;Humphries et al, 2009) can have their concentration altered in the plasma.…”

Section: General Approaches About the Action Mechanism Of The Wbv: Nementioning

confidence: 99%

Alterations on the plasma concentration of hormonal and non hormonal biomarkers in human beings submitted to whole body vibration exercises

Laisa¹,

Paula²,

Dulciane³

et al. 2015

Sci. Res. Essays

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Vibration is a mechanical stimulus that is characterized by an oscillatory motion. When there is a direct contact of a person, in general standing on the base of this type of platform, the vibration that is produced in these machines is transmitted to the body of the subject producing whole body vibration (WBV) exercises. Biological effects can be associated with the WBV exercises with desirable and undesirable consequences. These effects of the WBV exercises seem to be related to a direct effect in a tissue/organ/system and/or or to indirect effects due to alteration of the plasma concentration of some hormonal and non hormonal biomarkers. The aim of this investigation is to present a revision about hormonal and non hormonal biomarkers in human beings submitted to WBV exercises that have suffered alteration in the plasma concentrations. Searches were performed in the PubMed and Scopus databases with the key words "whole body vibration". Papers were selected following defined criteria. Considering the WBV exercise, hormonal fluctuations of testosterone, growth, insulin-like growth factor1, epinephrine, norepinephrine, cortisol, irisin, parathyroid hormone and sclerotin are observed. Non hormonal biomarkers have suffered alterations in response to WBV, as glucose, free fatty acids, adiponectin, transforming growth factor-beta1, nitric oxide, osteopontin, interleukin-1beta, bonespecific alkaline phosphatase, cartilage oligometric matrix protein and tumor necrosis factor-alpha in plasma concentration. In conclusion, putting together the findings related to the alterations of the concentration of hormonal and non hormonal biomarkers due to the WBV exercises, it is possible that the fluctuations in the plasma concentrations of these biomarkers might help us understand better the biological effects of this kind of exercises, probably due to neuroendrocrine responses.

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