Effects of x‐irradiation in newborn rats

Acute -lrradiation-lnduced Mortality in Chickens I. Mechanism of Resistance Afforded by Pretreatment with Cyclophosphamide or Sublethal Irradiation

“…This syndrome appears r a p idly after irradiation and includes an increase in vascular permeability, plasma leakage, hemoconcentration, and degenerative changes in the endothelium (2). This drastic increase in vascular permeability may represent an exaggerated form of similar permeability changes seen after irradiation in rabbits, rodents, and dogs (3,4). With the use of vital dyes in irradiated rabbit skin, Jolles and Harrison ( 5 ) showed that this leakage is abolished by pretreating the animals with alkylating agents, irradiation, or a protease inhibitor such as soy bean trypsin inhibitor (SBTI).…”

“…The only species which show this peculiar acute irradiation mortality are chickens and ducks (20). The other species of birds examined, including pigeons, parakeets, and canaries, do not exhibit this phenomenon (21).…”

Radiation Effects on Mammalian Systems

“…The situation becomes more complex at very low dose rates. A striking dose rate dependence for x-rays occurs in young birds (35) and, to a lesser extent, in newborn rats (36). Exposure of 2-to 3-day old chicks to 1000 r at 15 r/min.…”

Failure of Rutin and Related Flavonoids to Influence Mortality Following Acute Whole Body X-Irradiation.

“…Rekers and Field( 2) observed a reduced hemorrhagic tendency and obtained improved survival rates among irradiated dogs pretreated with rutin or other flavonoids. Similarly CVP had no beneficial effect in mice (9), and rutin and hesperidin failed to influence the mortality or hemorrhagic changes in irradiated young chicks ( 10). and Jordon( 3 ) obtained increased survival of guinea pigs treated with calcium flavonate.…”