Effects of xenon irradiation of the stellate ganglion region on fibromyalgia

Nakajima, Fukami; Komoda, A; Aratani, Satoko; Fujita, Hidetoshi; Kawate, Mariko; Nakatani, Kou; Akiyama, Mitoshi; Makita, Koshi; Nakajima, Takeshi

doi:10.1589/jpts.27.209

Cited by 13 publications

(9 citation statements)

References 28 publications

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“…Fibromyalgia syndrome (FMS), which is characterized by widespread pain and fatigue, is a disease that affects the connective tissues and locomotor system 1 , 2 , 3 ) . Patients with FMS also suffer from weakness, fatigue, lack of energy, sleep disturbances, waking up tired in the morning (non-restorative sleep), and stiffness.…”

Section: Introductionmentioning

confidence: 99%

The effects of aquatic, isometric strength-stretching and aerobic exercise on physical and psychological parameters of female patients with fibromyalgia syndrome

et al. 2015

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[Purpose] There are various treatment modalities for fibromyalgia syndrome (FMS), which is characterized by widespread pain and fatigue. The aim of this study was to investigate the effects of aquatic, aerobic and isometric strength-stretching exercises on the physical and psychological parameters of patients with FMS. [Subjects and Methods] Seventy five female patients with FMS were randomly selected and divided into three groups. Patients (18–50 years) were treated for 3 months using one of three methods: a home-based isometric strength and stretching exercise program (ISSEP), a gym-based aerobic exercise program (AEP), and a pool-based aquatic aerobic exercise program (AAEP). Items evaluated were: the number of tender points, Visual Analog Scale (VAS), Fibromyalgia Impact Questionnaire (FIQ), the Six-Minute Walk Test (6MWT), SF-36 physical and mental health scores, and the Beck Depression Inventory (BDI). [Results] The results revealed that AAEP was the most effective treatment of the three. All of the groups showed significant improvements in all variables between pre-and post-test, except the mean values of VAS and BDI in ISSEP. [Conclusion] The results suggest that aquatic aerobic exercise program is more effective than AEP and ISSEP in the treatment of FMS.

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Section: Introductionmentioning

confidence: 99%

The effects of aquatic, isometric strength-stretching and aerobic exercise on physical and psychological parameters of female patients with fibromyalgia syndrome

et al. 2015

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“…In addition, noninvasive SGB can be safely and conveniently performed in clinical practice, particularly in patients declining injections, having a high bleeding tendency, undergoing anticoagulant therapy, or having contraindications for nerve blockade, such as those with hemophilia [30–34]. In patients with neuropathic pain syndromes, the effects of SGB performed using light irradiation were similar to those of conventional intensive SGB, including improved blood flow through vasodilation and reduced pain by direct blockade of the afferent nociceptive signals traveling through sympathetic pathways [31, 33, 35–38]. Moreover, the effects of SGB performed using TENS [39–41] and therapeutic US [41, 42] were similar.…”

Section: Introductionmentioning

confidence: 99%

“…Noninvasive SGB can provide clinically effective pain relief, improve peripheral vasomotor and sudomotor dysfunction and abnormal heart rate variability (HRV), and maintain homeostasis in patients with neuropathic pain syndromes such as CRPS [40, 41, 43, 44, 46, 53, 57], fibromyalgia [33], glossodynia [52], burning mouth syndrome [31, 36, 58], postherpetic neuralgia [49, 59, 60], trigeminal neuralgia [61], and thalamic pain [55] as well as in those with other disorders such as Bell’s palsy [50, 51, 60], musculoskeletal pain [38], postoperative sensory disturbance [62], Raynaud’s phenomenon [63], glaucoma [64], and sudden deafness [65]. In addition, noninvasive SGB can alleviate conditions associated with hypersympathetic tone [35, 45, 47, 64–68] and physiological changes associated with suppressed sympathetic activities in healthy adults [34, 37, 42, 56, 69–75].…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of Noninvasive Stellate Ganglion Blockade Performed Using Physical Agent Modalities in Patients with Sympathetic Hyperactivity-Associated Disorders: A Systematic Review and Meta-Analysis

et al. 2016

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BackgroundStellate ganglion blockade (SGB) is mainly used to relieve symptoms of neuropathic pain in conditions such as complex regional pain syndrome and has several potential complications. Noninvasive SGB performed using physical agent modalities (PAMs), such as light irradiation and electrical stimulation, can be clinically used as an alternative to conventional invasive SGB. However, its application protocols vary and its clinical efficacy remains controversial. This study investigated the use of noninvasive SGB for managing neuropathic pain or other disorders associated with sympathetic hyperactivity.Materials and MethodsWe performed a comprehensive search of the following online databases: Medline, PubMed, Excerpta Medica Database, Cochrane Library Database, Ovid MEDLINE, Europe PubMed Central, EBSCOhost Research Databases, CINAHL, ProQuest Research Library, Physiotherapy Evidence Database, WorldWideScience, BIOSIS, and Google Scholar. We identified and included quasi-randomized or randomized controlled trials reporting the efficacy of SGB performed using therapeutic ultrasound, transcutaneous electrical nerve stimulation, light irradiation using low-level laser therapy, or xenon light or linearly polarized near-infrared light irradiation near or over the stellate ganglion region in treating complex regional pain syndrome or disorders requiring sympatholytic management. The included articles were subjected to a meta-analysis and risk of bias assessment.ResultsNine randomized and four quasi-randomized controlled trials were included. Eleven trials had good methodological quality with a Physiotherapy Evidence Database (PEDro) score of ≥6, whereas the remaining two trials had a PEDro score of <6. The meta-analysis results revealed that the efficacy of noninvasive SGB on 100-mm visual analog pain score is higher than that of a placebo or active control (weighted mean difference, −21.59 mm; 95% CI, −34.25, −8.94; p = 0.0008).ConclusionsNoninvasive SGB performed using PAMs effectively relieves pain of various etiologies, making it a valuable addition to the contemporary pain management armamentarium. However, this evidence is limited by the potential risk of bias.

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“…fibromyalgia in Japan, where it has a broader range of indications than other countries [4][5][6]. However, target diseases of SGB are sometimes controversial [4] because it is unclear why this therapy works.…”

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confidence: 99%

Near-Infrared Spectroscopic Examination of Alterations in Brain Surface Blood Flow following Stellate Ganglion Block

Nakajima¹

2016

SOJAPM

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Background: Stellate Ganglion Block (SGB) is used to treat pain and other disorders, but the target diseases of SGB are controversial because the mechanisms underlying SGB remain unclear. Increased cerebral blood flow is one of the processes presumed to be involved. The aim of this study was to clarify the effects of SGB by using nearinfrared spectroscopy to measure brain surface blood flow during and after SGB. Methods: The participants were nine healthy staff volunteers. Near-infrared spectroscopy was applied to subjects' heads, and the same operator performed a right SGB (1% mepivacaine 4 ml). Changes in oxy-hemoglobin (oxy-Hb) concentration were measured from approximately 30 s before administering SGB until approximately after 30 min. Results: For the mean brain waves between the right (block) side channels, oxy-Hb concentration immediately increased after SGB in four subjects, while it temporarily decreased after SGB and then increased in five subjects. For the mean brain waves between the left (contralateral) side channels, oxy-Hb concentration markedly decreased after SGB in four subjects. In three subjects, it temporarily increased immediately after SGB but decreased after approximately 15 min. almost no change in oxy-Hb concentration was observed in the remaining two subjects. Overall, oxy-Hb concentration increased in all subjects on the right (block) side. Discussion: Increased oxy-Hb concentrations suggest that SGB relaxed vascular tone, increased the capillary bed, and enhanced blood flow. However, oxy-Hb concentration temporarily decreased before it increased in five subjects. We assume that during the temporary decrease, blood flow was unable to keep up with this rate of increase in the capillary bed. In four subjects, oxy-Hb concentration markedly decreased contralateral to the block. This may have been due to higher blood volume on the block side, but the reasons are not fully known.

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Effects of xenon irradiation of the stellate ganglion region on fibromyalgia

Cited by 13 publications

References 28 publications

The effects of aquatic, isometric strength-stretching and aerobic exercise on physical and psychological parameters of female patients with fibromyalgia syndrome

The effects of aquatic, isometric strength-stretching and aerobic exercise on physical and psychological parameters of female patients with fibromyalgia syndrome

Efficacy of Noninvasive Stellate Ganglion Blockade Performed Using Physical Agent Modalities in Patients with Sympathetic Hyperactivity-Associated Disorders: A Systematic Review and Meta-Analysis

Near-Infrared Spectroscopic Examination of Alterations in Brain Surface Blood Flow following Stellate Ganglion Block

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