Effects of xylazine-ketamine, xylazine-propofol and xylazine-ketamine-propofol administration on free radical generation and blood gases in sheep

Abstract

This study was aimed at investigating the effects of xylazine-ketamine, xylazine-propofol and xylazine-ketamine-propofol combinations on oxidative stress, antioxidant capacity and blood gases in sheep. Excluding the control animals, the sheep included in Groups 1, 2 and 3 were administered with combinations of xylazine-ketamine, xylazine-propofol and xylazine-ketamine-propofol, respectively, by intravenous route. The comparison of the three treatment groups with the control group showed that no significant difference existed for TAS, TOS, MDA and CAT levels. The evaluation of blood gas and electrolyte levels demonstrated a significant decrease in PvO2, cSO2, Na, and Ca levels, and a significant increase in glucose levels. In result, this study showed that the three anaesthetic combinations tested did not have any adverse effect on the oxidant/antioxidant status, but caused significant alterations in blood gas levels.

Application of α2‐adrenergic agonists combined with anesthetics and their implication in pulmonary intravascular macrophages‐insulted pulmonary edema and hypoxemia in ruminants

“…In a current study, administration of XYL‐KET, XYL‐PRO, and XYL‐KET‐PRO combinations in sheep were found to have no impact on the total oxidant/antioxidant status, malondialdehyde, and catalase levels. Nonetheless, significant decreases in mixed venous oxygen pressure and cerebral oxygen saturation were accompanied with these combinations (Gokalp et al, 2020). Following DEX administration (2 μg/kg, IV) in sevoflurane‐anesthetized sheep, PE in combination with elevated capillary pressures was rapidly occurred, but without early inflammatory signs, suggesting that vascular hydrostatic stress may be attributable to the PE formation.…”

Combined Intake of Fish Oil and D-Fagomine Prevents High-Fat High-Sucrose Diet-Induced Prediabetes by Modulating Lipotoxicity and Protein Carbonylation in the Kidney

“…However, anesthetic doses of ketamine, especially in combination with xylazine, have shown some free radical scavenger activity in blood samples of sheep [ 61 ] and rabbits [ 62 ], increasing the stability of blood samples during storage. Nevertheless, some studies did not find any effects on redox blood status of sheep [ 63 ]. In this current study, the presence of the anesthetics in the plasma samples could have affected some oxidative stress measurements, and the effect of the HFHS diet could be attenuated in this fluid.…”