Effects of yeast-derived β-glucans on blood cholesterol and macrophage functionality

Větvička, Václav; Větvičková, Jana

doi:10.1080/15476910802604317

Cited by 37 publications

(28 citation statements)

References 28 publications

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“…No significant changes were observed in plasma lipid levels, in contrast to results from previous studies reporting that yeast‐derived products can also reduce plasma cholesterol levels . For instance, Nicolosi et al .…”

Section: Discussioncontrasting

confidence: 99%

Effect of a polysaccharide‐rich hydrolysate from Saccharomyces cerevisiae (LipiGo®) in body weight loss: randomised, double‐blind, placebo‐controlled clinical trial in overweight and obese adults

2017

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Section: Discussioncontrasting

confidence: 99%

Effect of a polysaccharide‐rich hydrolysate from Saccharomyces cerevisiae (LipiGo®) in body weight loss: randomised, double‐blind, placebo‐controlled clinical trial in overweight and obese adults

2017

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“…In an in vivo study, Vetvicka et al. found that yeast‐derived β‐glucan lowered the level of cholesterol in Balb/c mice in a dose‐dependent manner . Consistent with this research, we found that β‐glucan isolated from the cell wall of P. pastoris also exhibited hypolipidemic activity to a comparable level.…”

Section: Discussionsupporting

confidence: 90%

“…Multiple reports have shown that diets and drinks enriched with β-glucan lowered the level of total cholesterol, possibly by increasing the level of bile acid synthesis and decreasing the absorption of cholesterols [24]. In an in vivo study, Vetvicka et al found that yeast-derived β-glucan lowered the level of cholesterol in Balb/c mice in a dosedependent manner [23]. Consistent with this research, we found that β-glucan isolated from the cell wall of P. pastoris also exhibited hypolipidemic activity to a comparable level.…”

Section: Discussionmentioning

confidence: 99%

An environment‐friendly approach to isolate and purify glucan from spent cells of recombinant Pichia pastoris and the bioactivity characterization of the purified glucan

Xing

Chen

Sun

et al. 2018

Engineering in Life Sciences

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While the methylotrophic yeast Pichia pastoris enables the industrial‐scale biosynthesis of many recombinant products, large amount of nutrient‐rich biomass emerged along this process. Polysaccharides, especially glucans that are abundant in the cell wall of P. pastoris, are yet to be better utilized owing to their various biological activities. However, the isolation and purification of cell wall glucan from P. pastoris has not been reported. In this study, we established an environment‐friendly approach, including induced autolysis, hot‐water treatment, ultrasonication, isopropanol extraction, and protease treatment, to isolate and purify glucan from the cell wall of P. pastoris. We achieved a purity of 85.3% and a yield of 11.7% for the purified glucan. Proteins, nucleic acids, lipids, and ash were efficiently removed during the purification. The activities of the purified glucan were investigated in mice fed with a high‐fat diet. The purified glucan decreased the level of total cholesterol and triglycerides by 30.3 and 29.7%, respectively. This result suggested that the cell wall glucan of P. pastoris could be developed to a therapeutic agent for dyslipidemia. Our study proposed an environment‐friendly and effective method to isolate and purify the glucan from P. pastoris, providing solid foundation for the high‐value utilization of this yeast.

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“…The role of 1,3 β -glucans from yeast, fungi, mushrooms, and seaweed as biological immunomodulators has been well documented in the past 40 years [90]. In vitro , animal and human studies have shown that 1,3 β -glucans can enhance the responsiveness and function of immune cells, stimulating both humoral and cellular immunity [91].…”

Section: Beta Glucan Obesity and Metabolic Syndromementioning

confidence: 99%

Beta Glucan: Health Benefits in Obesity and Metabolic Syndrome

Khoury

Cuda

Luhovyy

et al. 2012

Journal of Nutrition and Metabolism

377

287

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Despite the lack of international agreement regarding the definition and classification of fiber, there is established evidence on the role of dietary fibers in obesity and metabolic syndrome. Beta glucan (β-glucan) is a soluble fiber readily available from oat and barley grains that has been gaining interest due to its multiple functional and bioactive properties. Its beneficial role in insulin resistance, dyslipidemia, hypertension, and obesity is being continuously documented. The fermentability of β-glucans and their ability to form highly viscous solutions in the human gut may constitute the basis of their health benefits. Consequently, the applicability of β-glucan as a food ingredient is being widely considered with the dual purposes of increasing the fiber content of food products and enhancing their health properties. Therefore, this paper explores the role of β-glucans in the prevention and treatment of characteristics of the metabolic syndrome, their underlying mechanisms of action, and their potential in food applications.

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Effects of yeast-derived β-glucans on blood cholesterol and macrophage functionality

Cited by 37 publications

References 28 publications

Effect of a polysaccharide‐rich hydrolysate from Saccharomyces cerevisiae (LipiGo®) in body weight loss: randomised, double‐blind, placebo‐controlled clinical trial in overweight and obese adults

Effect of a polysaccharide‐rich hydrolysate from Saccharomyces cerevisiae (LipiGo®) in body weight loss: randomised, double‐blind, placebo‐controlled clinical trial in overweight and obese adults

An environment‐friendly approach to isolate and purify glucan from spent cells of recombinant Pichia pastoris and the bioactivity characterization of the purified glucan

Beta Glucan: Health Benefits in Obesity and Metabolic Syndrome

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