Effects of Yi-Gan-san on the psychiatric behavior of children and adolescents with Tourette's Syndrome: A randomized, double-blind, controlled preliminary study

Huang, Cheng-Hao; Liao, Wen‐Ling; Lee, Der-Yen; Chou, I-Ching; Wang, Mingyu; Hsieh, Ching-Liang

doi:10.1016/j.jep.2022.115098

Cited by 5 publications

(4 citation statements)

References 19 publications

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“…Além disto, mesmo que disponíveis para o tratamento dos tiques na ST, o uso desses antipsicóticos em crianças e adolescentes podem também estar associados a comprometimento cognitivo, ganho de peso, letargia e discinesia tardia (HUANG et al, 2022;JANKOVIC et al, 2021;KAHL et al, 2021;RIZZO et al, 2022).…”

Section: Discussionunclassified

“…Dessa forma, após a leitura e análise dos resultados obtidos a partir dos diferentes estudos clínicos e randomizados, a discussão se fundamenta a partir de diferentes tópicos acerca Apesar desse resultado, em decorrência da similaridade entre os resultados de ambos os grupos após 4 semanas, em que todos obtiveram melhora de sintomas como toques motores e fônicos, e da preparação do placebo, que contou com 10% do YGS, um dos aspectos a serem investigados futuramente seria a seleção de placebo e de dosagem mais apropriados. Ademais, por se tratar também de um estudo preliminar, com pequeno tamanho de amostra, tais fatores devem ser levados em consideração em estudos futuros (HUANG et al, 2022). avaliou a eficácia que a suplementação de L-teanina, um aminoácido, e a vitamina B6 possuem na redução de tiques em jovens com transtorno do tique crônico ou com ST (RIZZO et al, 2022).…”

Section: Discussionunclassified

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Tratamento da síndrome de Tourette em pacientes pediátricos e novos ensaios clínicos randomizados: uma revisão integrativa

De Lima,

Carmozini,

Scanavez

et al. 2023

Braz. J. Hea. Rev.

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A síndrome de Tourette (ST) é definida como um distúrbio do neurodesenvolvimento em que estão presentes tiques motores simples e vocais ou fônicos, com prevalência de 1% das crianças em idade escolar, sendo mais presente em meninos e com uma proporção de 4:1 entre homens e mulheres. O presente estudo de revisão buscou avaliar novas evidências na abordagem terapêutica da ST na população pediátrica, documentadas por meio de estudos clínicos e randomizados. Trata-se de uma pesquisa de revisão integrativa realizada por meio da base de dados PubMed, que levou em consideração os seguintes critérios de inclusão: ensaios clínicos e testes controlados e randomizados; artigos publicados nos últimos três anos; que possuíam texto completo disponível e que abordassem acerca de novas evidências no tratamento da ST em crianças. Ficou constatado que o Yi-Gan-san (YGS), enquanto fórmula da medicina tradicional chinesa, trouxe redução da intensidade dos tiques fônicos, sendo capaz de atuar em curto período de tempo em crianças e adolescentes com ST. Além disso, verificou-se que a estimulação magnética transcraniana repetitiva (EMTr) promoveu melhora da gravidade dos tiques, sugerindo ser uma técnica terapêutica capaz de intervir de forma segura e fisiologicamente direcionada para o tratamento de tiques de crianças com ST. Por fim, os suplementos compostos de L-teanina e piridoxina promoveram redução da gravidade dos tiques e da ansiedade, sendo evidente o papel que a L-teanina e a vitamina B6 possuem no tratamento de transtornos de tiques como a ST.

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Section: Discussionunclassified

Tratamento da síndrome de Tourette em pacientes pediátricos e novos ensaios clínicos randomizados: uma revisão integrativa

De Lima,

Carmozini,

Scanavez

et al. 2023

Braz. J. Hea. Rev.

View full text Add to dashboard Cite

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“…Since modified forms are widely used in combination, the questionnaire in this study included a modified form in response to Ondam-tang. Eokgan-san has been prescribed for restlessness and agitation in children and has been reported to improve the behavioral and psychological symptoms of dementia [ 45 , 46 ] and Tourette’s syndrome symptoms in children and adolescents for a short period of time [ 47 ]. Sihogayonggolmororyeo-tang (written as Chaihu Jia Longgu Muli decoction in Chinese) has been reported to have an antiepileptic effect in an experimental study on rats [ 48 ], and in an SR, it was found to be more effective than conventional medicine in the treatment of post-stroke depression [ 49 ] and insomnia [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

A National Survey on the Clinical Practice Patterns of Korean Medicine Doctors for Attention Deficit Hyperactivity Disorder (ADHD) in Children and Adolescents

Lee

2023

Children

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To alleviate the symptoms of attention deficit/hyperactivity disorder (ADHD) in children and reduce the side effects of psychostimulants, parents are opting for complementary and alternative medicine as a therapeutic option. Korean medicine (KM) has been used by Korean medicine doctors (KMDs) to treat ADHD with herbal medication and acupuncture. This study aimed to conduct a cross-sectional survey on the clinical practice patterns of KM for ADHD in children targeting KMDs. The questionnaire included aspects related to patient characteristics, diagnosis, treatment modalities, and perceptions regarding KM. Questionnaires were distributed to all KMDs via e-mail, and the online surveys were conducted from 1 to 15 February 2023. A total 2.1% of KMDs (n = 537/25,574) completed the survey. The predominant diagnostic pattern identification employed was “depressed liver qi transforming into fire” (19.8%). Herbal medicine (HM) was the most common treatment (44.2%). The most frequently used HM prescriptions were Ondam-tang (16.9%), Eokgan-san (15.7%), and Sihogayonggolmoryeo-tang (14.4%). KMDs recognized HM as the most effective among the KM treatments (54.3%). The results of this study elucidate the current clinical practice patterns of KM for ADHD. Based on these findings, a treatment protocol can be developed to provide optimized KM treatment services to patients with ADHD.

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“…In a DB‐RCT by Huang et al [65], 38 children and adolescents with Tourette syndrome were randomly allocated to the YKS group that received 5 g/day of YKS extract for four weeks or the control group that received a placebo. The Yale Global Tic Severity Scale scores were compared at weekly intervals after administration; however, a significant difference was found only in the first week after administration.…”

Section: Clinical Studies Of Yksmentioning

confidence: 99%

A review of frequently used Kampo prescriptions. Part 3. Yokukansan

Yamaguchi,

Yoshino,

Oizumi

et al. 2023

Traditional & Kampo Medicine

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BackgroundThe source of yokukansan (YKS) is thought to be Baoying‐Jinjiang (Hoeikinkyōroku in Japanese) by Xue Ji. YKS was originally designed for children and indicated for spasms, clenching of teeth, digestive dysfunction due to mental instability, and insomnia.Key FindingsYKS formula consists of seven types of crude drugs. Clinical studies have revealed that YKS exerts physiological effects including the treatment of behavioral and psychiatric symptoms of dementia (BPSD), preoperative sedation and anxiety, and postoperative delirium. A meta‐analysis showed that YKS could improve BPSD and daily living activities; however, no improvement in cognitive function was observed. Preclinical studies have also reported that YKS modulates neuronal pathways in the central nervous system, including the serotonergic, glutamatergic, GABAergic, and other neurotransmitter pathways. The incidence of adverse events associated with YKS was 5.17%, with the major adverse effect being pseudoaldosteronism. Routine blood sampling is considered for hypokalemia prevention.ConclusionYKS is useful for BPSD and perioperative mental instability. The modulation of the serotonergic and glutamatergic neural pathways is one of mechanisms. Pseudoaldosteronism is one of the side effects.

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Effects of Yi-Gan-san on the psychiatric behavior of children and adolescents with Tourette's Syndrome: A randomized, double-blind, controlled preliminary study

Cited by 5 publications

References 19 publications

Tratamento da síndrome de Tourette em pacientes pediátricos e novos ensaios clínicos randomizados: uma revisão integrativa

Tratamento da síndrome de Tourette em pacientes pediátricos e novos ensaios clínicos randomizados: uma revisão integrativa

A National Survey on the Clinical Practice Patterns of Korean Medicine Doctors for Attention Deficit Hyperactivity Disorder (ADHD) in Children and Adolescents

A review of frequently used Kampo prescriptions. Part 3. Yokukansan

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