Effects of Yishen Pinggan Recipe on Renal Protection and NF‐<i>κ</i>B Signaling Pathway in Spontaneously Hypertensive Rats

Luo, Guodong; Zhu, Xiying; Gao, Zhonghong; Ge, Hua-xun; Yu, Yang; Guo, Yuanyuan; Zheng, Jing; Long-min, Liu

doi:10.1155/2016/6435040

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…The current animal models, used to study for hypertension, are mainly hereditary hypertensive animal models (spontaneously hypertensive rats (SHR) [ 49 , 50 ], stroke-prone spontaneously hypertensive rats [ 51 ], Dahl salt-sensitive hypertensive rats [ 52 ], etc. ), renovascular hypertensive animal models (2-kidney-1-clip, 2K1C [ 53 ] and 2-kidney-2-clip, 2K2C [ 54 ], etc.…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effects of Paeoniflorin Enriched Extract on Blood Pressure Variability and Target Organ Damage in Spontaneously Hypertensive Rats

Yang

Lei

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Blood pressure variability (BPV) is associated with the development and progression of severe target organ damage (TOD). This study aims to evaluate the protective effect of paeoniflorin enriched extract from Radix Paeoniae Alba (PG) on BPV and TOD in spontaneously hypertensive rats (SHR). All SHR were orally treated with distilled water, metoprolol (MP, 20 mg/kg), and PG (PG-H, 90 mg/kg or PG-L, 30 mg/kg) for a single time or daily for 7 weeks. The 24-hour dynamic blood pressure was monitored and then calculated BPV including long- and short-term systolic blood pressure variability (SBPV), diastolic blood pressure variability (DBPV), mean blood pressure variability (MBPV), and heart rate variability (HRV) as well as the 24-hour-SBP, 24-hour-DBP, and 24-hour-MBP. The protective effects of PG on TOD were observed by histopathologic and biochemical detection. The results indicated that long- and short-term SBPV, DBPV, MBPV, and HRV as well as 24-hour-SBP, 24-hour-DBP, and 24-hour-MBP showed no significant changes after single-dose administration of PG and significantly decreased after administration with PG for 7 weeks. PG could also markedly improve the damage of aorta, heart, kidney, and brain. This study suggested that PG could notably reduce BPV, stabilize blood pressure, and mitigate TOD in SHR.

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Section: Discussionmentioning

confidence: 99%

Beneficial Effects of Paeoniflorin Enriched Extract on Blood Pressure Variability and Target Organ Damage in Spontaneously Hypertensive Rats

Yang

Lei

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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“…In the hypertensive rat's kidney, Infl ammatory cytokines expression was upregulated [15]. These induce membranous glomerulonephritis in rats [16]. Also, an infl ammatory infi ltration by macrophages and lymphocytes occurs in the kidney of hypertensive animals [17].…”

Section: Introductionmentioning

confidence: 99%

Effect of hypercholesterolemia on hypertension-induced renal injury in rats: Insights in the possible mechanisms

Abdel-Zaher¹,

Farghaly²,

El-Refaiy³

et al. 2020

J Cardiovasc Med Cardiol

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The effect of hypercholesterolemia on hypertension-induced renal injury was investigated in rats. Hypertension was induced by L-N(G)-nitroarginine methyl ester (L-NAME) and Hypercholesterolemia was induced by feeding rats with a diet containing 1% cholesterol. In these animals L-NAME produced a progressive increase in the systolic, diastolic and mean arterial Blood Pressure (BP). Similarly, L-NAME with hypercholesterolemia produced, in addition to compromised serum lipid profi le, a progressive increase in the systolic, diastolic and mean arterial BP. Hypercholesterolemia enhanced the hypertensive effect of L-NAME. Also, hypercholesterolemia enhanced hypertension-induced renal injury as assessed by measurement of serum renal function markers and by histopathological examination. Concomitantly, hypertension-induced elevation of renal tissue Malondialdehyde (MDA) and nitrite levels and reduction of intracellular reduced Glutathione (GSH) level were enhanced by hypercholesterolemia. In addition, hypertension -induced increases in tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β) and Intercellular Adhesion Molecule-1 (ICAM-1) levels in renal tissues were increased by hypercholesterolemia. These results indicate that hypercholesterolemia has the ability to enhance hypertension-induced renal injury. The ability of hypercholesterolemia to provide this effect may positively correlate to its ability to increase renal oxidative stress, nitrosative stress and infl ammation.

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Protective effect of the standardized leaf extract of Ginkgo biloba (EGb761) against hypertension-induced renal injury in rats

Abdel-Zaher

Farghaly

Refaiy

et al. 2018

Clinical and Experimental Hypertension

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Effects of Yishen Pinggan Recipe on Renal Protection and NF‐κB Signaling Pathway in Spontaneously Hypertensive Rats

Cited by 3 publications

References 16 publications

Beneficial Effects of Paeoniflorin Enriched Extract on Blood Pressure Variability and Target Organ Damage in Spontaneously Hypertensive Rats

Beneficial Effects of Paeoniflorin Enriched Extract on Blood Pressure Variability and Target Organ Damage in Spontaneously Hypertensive Rats

Effect of hypercholesterolemia on hypertension-induced renal injury in rats: Insights in the possible mechanisms

Protective effect of the standardized leaf extract of Ginkgo biloba (EGb761) against hypertension-induced renal injury in rats

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