Effects of yogic intervention on pain scores and quality of life in females with chronic pelvic pain

Saxena, Rahul; Gupta, Manish; Shankar, Nilima; Jain, Sandhya; Saxena, Arushi

doi:10.4103/0973-6131.186155

Cited by 30 publications

(18 citation statements)

References 25 publications

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“…Exercise interventions have improved pain and quality of life scores in women with chronic pelvic pain (66). Additional studies have shown similar improvements in both pain and overall wellbeing in irritable bowel syndrome, migraine, and fibromyalgia patients (20).…”

Section: Discussionmentioning

confidence: 94%

Voluntary wheel running improves outcomes in an early life stress-induced model of urologic chronic pelvic pain syndrome in male mice

Fuentes

Jones

Brake

et al. 2020

Preprint

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Patients with a history of early life stress (ELS) exposure have an increased risk of developing chronic pain and mood disorders later in life. The severity of ELS in patients with urologic chronic pelvic pain syndrome (UCPPS) is directly correlated with symptom severity and increased comorbidity, and is inversely related to likelihood of improvement. Voluntary exercise improves chronic pain symptoms and our group and others have shown that voluntary wheel running can improve outcomes in stress-induced UCPPS models, suggesting that exercise may negate some of the outcomes associated with ELS. Here we provide further evidence that voluntary wheel running can attenuate increased perigenital mechanical sensitivity, bladder output, and mast cell degranulation in the bladder and prostate in male mice that underwent neonatal maternal separation (NMS). Sedentary male NMS mice had reduced serum corticosterone, which was not impacted by voluntary wheel running, although stress-related regulatory gene expression in the hypothalamus and hippocampus was significantly increased following exercise. Neurogenesis in the dentate gyrus of the hippocampus was diminished in sedentary NMS mice and significantly increased in both exercised naïve and NMS mice. Sucrose consumption increased in exercised naïve but not NMS mice, and anxiety behaviors measured on an elevated plus maze were increased following exercise. Together these data suggest that voluntary wheel running is sufficient to normalize many of the UCPPS-related outcomes resulting from NMS. Exercise also increased hippocampal neurogenesis and stress-related gene expression within the hypothalamic-pituitary-adrenal axis, further supporting exercise as a non-pharmacological intervention for attenuating outcomes related to ELS exposure.

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Section: Discussionmentioning

confidence: 94%

Voluntary wheel running improves outcomes in an early life stress-induced model of urologic chronic pelvic pain syndrome in male mice

Fuentes

Jones

Brake

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…In a 12-week exercise intervention in patients with IBS, exercise led to improvements in the IBS Severity Scoring System score, which includes measurements in pain severity and pain frequency, and IBS-quality of life score, which measures qualities related to emotional functioning compared to patients that received usual care for IBS (Johannesson et al, 2011 ). Similarly, in a cohort of women with chronic pelvic pain, an 8-week yoga intervention resulted in improvement in pain and quality of life scores compared to the control group that was treated with non-steroidal anti-inflammatory drugs (Saxena et al, 2017 ). The frequency, intensity, and duration of migraine pain was significantly reduced when 12 weeks of outdoor walking was added to the treatment regime of migraine patients taking amitriptyline (Santiago et al, 2014 ) and Nordic walking (walking with poles) for 15 weeks resulted in improvements in the Fibromyalgia Impact Questionnaire score compared to control fibromyalgia patients (Mannerkorpi et al, 2010 ).…”

Section: Therapeutic Interventionsmentioning

confidence: 99%

Potential Mechanisms Underlying Centralized Pain and Emerging Therapeutic Interventions

Eller

Nicol

Christianson

2018

Front. Cell. Neurosci.

169

140

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Centralized pain syndromes are associated with changes within the central nervous system that amplify peripheral input and/or generate the perception of pain in the absence of a noxious stimulus. Examples of idiopathic functional disorders that are often categorized as centralized pain syndromes include fibromyalgia, chronic pelvic pain syndromes, migraine, and temporomandibular disorder. Patients often suffer from widespread pain, associated with more than one specific syndrome, and report fatigue, mood and sleep disturbances, and poor quality of life. The high degree of symptom comorbidity and a lack of definitive underlying etiology make these syndromes notoriously difficult to treat. The main purpose of this review article is to discuss potential mechanisms of centrally-driven pain amplification and how they may contribute to increased comorbidity, poorer pain outcomes, and decreased quality of life in patients diagnosed with centralized pain syndromes, as well as discuss emerging non-pharmacological therapies that improve symptomology associated with these syndromes. Abnormal regulation and output of the hypothalamic-pituitary-adrenal (HPA) axis is commonly associated with centralized pain disorders. The HPA axis is the primary stress response system and its activation results in downstream production of cortisol and a dampening of the immune response. Patients with centralized pain syndromes often present with hyper- or hypocortisolism and evidence of altered downstream signaling from the HPA axis including increased Mast cell (MC) infiltration and activation, which can lead to sensitization of nearby nociceptive afferents. Increased peripheral input via nociceptor activation can lead to “hyperalgesic priming” and/or “wind-up” and eventually to central sensitization through long term potentiation in the central nervous system. Other evidence of central modifications has been observed through brain imaging studies of functional connectivity and magnetic resonance spectroscopy and are shown to contribute to the widespreadness of pain and poor mood in patients with fibromyalgia and chronic urological pain. Non-pharmacological therapeutics, including exercise and cognitive behavioral therapy (CBT), have shown great promise in treating symptoms of centralized pain.

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“…Two randomized controlled trials examining a yoga intervention demonstrated improvements pain and quality of life in patients with CPP. 115,116 In patients with dysmenorrhea, pain symptoms improved as a result of an exercise intervention in four randomized controlled trials. [117][118][119][120]…”

Section: Non-pharmacologic Optionsmentioning

confidence: 99%

Psychology of Chronic Pelvic Pain: Prevalence, Neurobiological Vulnerabilities, and Treatment

Till¹,

As‐Sanie²,

Schrepf

2019

Clinical Obstetrics &Amp; Gynecology

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Patients with pelvic pain suffer from psychological conditions at a disportionately high rate compared to their peers. We review environmental, genetic, inflammatory, and neurobiological factors that increase vulnerability to developing both of these conditions. We review treatment strategies for chronic pelvic pain in patients who have comorbid psychological conditions, including both non-pharmacologic and pharmacologic options.

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Effects of yogic intervention on pain scores and quality of life in females with chronic pelvic pain

Cited by 30 publications

References 25 publications

Voluntary wheel running improves outcomes in an early life stress-induced model of urologic chronic pelvic pain syndrome in male mice

Voluntary wheel running improves outcomes in an early life stress-induced model of urologic chronic pelvic pain syndrome in male mice

Potential Mechanisms Underlying Centralized Pain and Emerging Therapeutic Interventions

Psychology of Chronic Pelvic Pain: Prevalence, Neurobiological Vulnerabilities, and Treatment

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