Effects of zinc against mercury toxicity in female rats 12 and 48 hours after HgCl2 exposure

Mesquita, Mariana; Tf, Pedroso; Cs, Oliveira; Va, Oliveira; Santos, Rafael F.; Bizzi, Cezar A.; Me, Pereira

doi:10.17179/excli2015-709

Cited by 15 publications

(7 citation statements)

References 48 publications

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“…In vivo and vitro studies have shown that exposure to Hg results in an upregulation of MT expression ( Agarwal et al, 2010 , Agrawal et al, 2014 , Oliveira et al, 2020 , Zalups and Koropatnick, 2000 ). Moreover, increased expression of MT has been shown to prevent Hg-induced inhibition of δ-aminolevulinic acid dehydratase and also provided some protection against Hg-induced reductions in GFR in in vivo models ( Mesquita et al, 2016 , Oliveira et al, 2020 ). Studies using in vitro models have also shown that upregulation of MT protects against many Hg-induced cellular alterations, including reduced cell viability, DNA damage, and increased reactive oxygen species ( Hossain et al, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

Proximal tubular transport of Metallothionein-Mercury complexes and protection against nephrotoxicity

Dave,

Joshee,

Barfuss

et al. 2023

Current Research in Toxicology

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Section: Resultsmentioning

confidence: 99%

Proximal tubular transport of Metallothionein-Mercury complexes and protection against nephrotoxicity

Dave,

Joshee,

Barfuss

et al. 2023

Current Research in Toxicology

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“…While there is strong evidence that certain forms of mercury can cross the placenta and accumulate in the developing child [ 81 ], this is not the case for inorganic mercury [ 82 ] and maternal variance of this compound may be irrelevant to prenatal exposure. Secondly, concentrations of micronutrients and other elements such as zinc [ 83 ], along with the infants’ mercury metabolism, are likely to affect the half-life of mercury and were also not measured. Studies that are able to include these elements as covariates will have greater model precision by accounting for more outcome variance, which would provide greater power to detect smaller effect sizes.…”

Section: Discussionmentioning

confidence: 99%

Prenatal Mercury Exposure and Infant Weight Trajectories in a UK Observational Birth Cohort

Dack

Wootton

Taylor

et al. 2022

Toxics

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Mercury is highly toxic metal found in trace quantities in common foods. There is concern that exposure during pregnancy could impair infant development. Epidemiological evidence is mixed, but few studies have examined postnatal growth. Differences in nutrition, exposures, and the living environment after birth may make it easier to detect a negative impact from mercury toxicity on infant growth. This study includes 544 mother–child pairs from the Avon Longitudinal Study of Parents and Children. Blood mercury was measured in early pregnancy and infant weight at 10 intervals between 4 and 61 months. Mixed-effect models were used to estimate the change in infant weight associated with prenatal mercury exposure. The estimated difference in monthly weight gain was −0.02 kg per 1 standard deviation increase in Hg (95% confidence intervals: −0.10 to 0.06 kg). When restricted to the 10th decile of Hg, the association with weight at each age level was consistently negative but with wide confidence intervals. The lack of evidence for an association may indicate that at Hg levels in this cohort (median 1.9 µg/L) there is minimal biological impact, and the effect is too small to be either clinically relevant or detectable.

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“…Studies have reported associations between singlenucleotide polymorphisms (SNPs) in genes related to Hg metabolism and internal levels of Hg, such as in the glutathione metal-binding detoxification system [43][44][45], the metallothionein metal transport family [46], lipid-transport protein apolipoprotein-E [47], and genes involved in iron homeostasis [48]. Hg interacts with other elements such as selenium [49], zinc [50,51], cadmium, and lead [52,53], and variants which alter concentrations of these elements may also impact Hg [54][55][56]. The utility of identifying SNP-Hg associations is twofold; first, it can enhance our understanding of the biological mechanisms of how Hg acts on the body, second, it may enable new methods to test the impact of Hg on health by using SNPs as randomised proxies of Hg exposure [57].…”

Section: Introductionmentioning

confidence: 99%

Genome-Wide Association Study of Blood Mercury in European Pregnant Women and Children

Dack,

Bustamante,

Taylor

et al. 2023

Genes

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Mercury has high industrial utility and is present in many products, and environmental contamination and occupational exposure are widespread. There are numerous biological systems involved in the absorption, metabolism, and excretion of Hg, and it is possible that some systems may be impacted by genetic variation. If so, genotype may affect tissue concentrations of Hg and subsequent toxic effects. Genome-wide association testing was performed on blood Hg samples from pregnant women of the Avon Longitudinal Study of Parents and Children (n = 2893) and children of the Human Early Life Exposome (n = 1042). Directly-genotyped single-nucleotide polymorphisms (SNPs) were imputed to the Haplotype Reference Consortium r1.1 panel of whole genotypes and modelled againstlog-transformed Hg. Heritability was estimated using linkage disequilibrium score regression. The heritability of Hg was estimated as 24.0% (95% CI: 16.9% to 46.4%) in pregnant women, but could not be determined in children. There were 16 SNPs associated with Hg in pregnant women above a suggestive p-value threshold (p < 1 × 10−5), and 21 for children. However, no SNP passed this threshold in both studies, and none were genome-wide significant (p < 5 × 10−8). SNP-Hg associations were highly discordant between women and children, and this may reflect differences in metabolism, a gene–age interaction, or dose–response effects. Several suggestive variants had plausible links to Hg metabolism, such as rs146099921 in metal transporter SLC39A14, and two variants (rs28618224, rs7154700) in potassium voltage-gated channel genes. The findings would benefit from external validation, as suggestive results may contain both true associations and false positives.

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Effects of zinc against mercury toxicity in female rats 12 and 48 hours after HgCl2 exposure

Cited by 15 publications

References 48 publications

Proximal tubular transport of Metallothionein-Mercury complexes and protection against nephrotoxicity

Proximal tubular transport of Metallothionein-Mercury complexes and protection against nephrotoxicity

Prenatal Mercury Exposure and Infant Weight Trajectories in a UK Observational Birth Cohort

Genome-Wide Association Study of Blood Mercury in European Pregnant Women and Children

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