Effects of Zinc and Menthol-Based Diets on Co-Selection of Antibiotic Resistance among E. coli and Enterococcus spp. in Beef Cattle

Murray, Sarah A.; Amachawadi, Raghavendra G.; Norman, Keri N.; Lawhon, Sara D.; Nagaraja, T. G.; Drouillard, James S.; Scott, H. M.

doi:10.3390/ani11020259

Cited by 7 publications

(4 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Phenotypic resistance to chloramphenicol, ciprofloxacin, gentamicin, linezolid, penicillin, streptomycin, vancomycin, zinc, and copper were not associated with copper supplementation ( 39 ). Comparably, an association between zinc supplementation and tetracycline resistance was reported ( 43 ) but had no other resistance associations ( 39 , 43 ).…”

Section: Resultsmentioning

confidence: 96%

“…Cattle represented in the articles were yearlings (n = 10), fallplaced calves (n = 5), cows and pre-weaned calves at cow-calf operations (n = 2), and finished cattle preslaughter (n = 2). Five studies described cattle whose age or weight was not defined; however, these parameters were estimated based on the study context (36,(42)(43)(44)(45). The remaining seven studies examined beef samples at retail.…”

Section: Study Characteristicsmentioning

confidence: 99%

See 1 more Smart Citation

Factors associated with antimicrobial resistant enterococci in Canadian beef cattle: A scoping review

et al. 2023

View full text Add to dashboard Cite

IntroductionAntimicrobial resistance (AMR) is a global health concern, occurring when bacteria evolve to render antimicrobials no longer effective. Antimicrobials have important roles in beef production; however, the potential to introduce AMR to people through beef products is a concern. This scoping review identifies factors associated with changes in the prevalence of antimicrobial-resistant Enterococcus spp. applicable to the Canadian farm-to-fork beef continuum.MethodsFive databases (MEDLINE, BIOSIS, Web of Science, Embase, and CAB Abstracts) were searched for articles published from January 1984 to March 2022, using a priori inclusion criteria. Peer-reviewed articles were included if they met all the following criteria: written in English, applicable to the Canadian beef production context, primary research, in vivo research, describing an intervention or exposure, and specific to Enterococcus spp.ResultsOut of 804 screened articles, 26 were selected for inclusion. The included articles discussed 37 factors potentially associated with AMR in enterococci, with multiple articles discussing at least two of the same factors. Factors discussed included antimicrobial administration (n = 16), raised without antimicrobials (n = 6), metal supplementation (n = 4), probiotics supplementation (n = 3), pen environment (n = 2), essential oil supplementation (n = 1), grass feeding (n = 1), therapeutic versus subtherapeutic antimicrobial use (n = 1), feeding wet distiller grains with solubles (n = 1), nutritional supplementation (n = 1) and processing plant type (n = 1). Results were included irrespective of their quality of evidence.DiscussionComparability issues arising throughout the review process were related to data aggregation, hierarchical structures, study design, and inconsistent data reporting. Findings from articles were often temporally specific in that resistance was associated with AMR outcomes at sampling times closer to exposure compared to studies that sampled at longer intervals after exposure. Resistance was often nuanced to unique gene and phenotypic resistance patterns that varied with species of enterococci. Intrinsic resistance and interpretation of minimum inhibitory concentration varied greatly among enterococcal species, highlighting the importance of caution when comparing articles and generalizing findings.Systematic Review Registration[http://hdl.handle.net/1880/113592]

show abstract

Section: Resultsmentioning

confidence: 96%

Section: Study Characteristicsmentioning

confidence: 99%

Factors associated with antimicrobial resistant enterococci in Canadian beef cattle: A scoping review

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Menthol (an EO) has been suggested as an antibiotic alternative in cattle. US studies [116,117] on feedlot cattle fed menthol (0.3%) reported no increased resistance in E. coli isolates to many antibiotics (amoxicillin, ampicillin, azithromycin, cefoxitin, ceftiofur, ceftriaxone, chloramphenicol, ciprofloxacin, gentamicin, kanamycin, nalidixic acid, streptomycin, sulfisoxazole, and sulphamethoxazole); but did observe some reduced sensitivity to tetracycline. It is not clear from these studies why a concentration of 0.3% was used, and trials were not carried out to determine the effect of different concentrations of menthol in feed on co-selection.…”

Section: Impact Of Biocides On Amr In Food Animal Productionmentioning

confidence: 95%

A Critical Review of AMR Risks Arising as a Consequence of Using Biocides and Certain Metals in Food Animal Production

James,

Onarinde

et al. 2023

Antibiotics

View full text Add to dashboard Cite

The focus of this review was to assess what evidence exists on whether, and to what extent, the use of biocides (disinfectants and sanitizers) and certain metals (used in feed and other uses) in animal production (both land and aquatic) leads to the development and spread of AMR within the food chain. A comprehensive literature search identified 3434 publications, which after screening were reduced to 154 relevant publications from which some data were extracted to address the focus of the review. The review has shown that there is some evidence that biocides and metals used in food animal production may have an impact on the development of AMR. There is clear evidence that metals used in food animal production will persist, accumulate, and may impact on the development of AMR in primary animal and food production environments for many years. There is less evidence on the persistence and impact of biocides. There is also particularly little, if any, data on the impact of biocides/metal use in aquaculture on AMR. Although it is recognized that AMR from food animal production is a risk to human health there is not sufficient evidence to undertake an assessment of the impact of biocide or metal use on this risk and further focused in-field studies are needed provide the evidence required.

show abstract

“…No tylosin treatment, no DFM treatment, and day 0 were used as a baseline. A similar approach has previously been employed for log-transformed quantitative plate count data in a cattle experimental design [ 27 ]. Due to the low percentage of growth on erythromycin-supplemented agar plates, a Cragg hurdle regression model was used for the analysis of the dependent variable of log 10 CFU per gram of feces for erythromycin-resistant enterococci, using the same independent factors as the multilevel mixed effect linear regression.…”

Section: Methodsmentioning

confidence: 99%

Effects of Tylosin, a Direct-Fed Microbial and Feedlot Pen Environment on Phenotypic Resistance among Enterococci Isolated from Beef Cattle Feces

et al. 2022

Self Cite

View full text Add to dashboard Cite

In two sequential replicates (n = 90 and n = 96 feedlot finisher cattle, respectively) we measured the impact of an Enterococcus faecium-based probiotic (DFM) and an altered feedlot pen environment on antimicrobial resistance among fecal enterococci in cattle fed (or, not fed) the macrolide tylosin. Diluted fecal samples were spiral-plated on plain and antibiotic-supplemented m-Enterococcus agar. In the first replicate, tylosin significantly (p < 0.05) increased the relative quantity of erythromycin-resistant enterococci. This effect was diminished in cattle fed the DFM in conjunction with tylosin, indicating a macrolide susceptible probiotic may help mitigate resistance. A similar observed effect was not statistically significant (p > 0.05) in the second replicate. Isolates were speciated and resistance phenotypes were obtained for E. faecium and E. hirae. Susceptible strains of bacteria fed as DFM may prove useful for mitigating the selective effects of antibiotic use; however, the longer-term sustainability of such an approach remains unclear.

show abstract

Effects of Zinc and Menthol-Based Diets on Co-Selection of Antibiotic Resistance among E. coli and Enterococcus spp. in Beef Cattle

Cited by 7 publications

References 44 publications

Factors associated with antimicrobial resistant enterococci in Canadian beef cattle: A scoping review

Factors associated with antimicrobial resistant enterococci in Canadian beef cattle: A scoping review

A Critical Review of AMR Risks Arising as a Consequence of Using Biocides and Certain Metals in Food Animal Production

Effects of Tylosin, a Direct-Fed Microbial and Feedlot Pen Environment on Phenotypic Resistance among Enterococci Isolated from Beef Cattle Feces

Contact Info

Product

Resources

About