Effects of Zinc Supplementation on Serum Zinc and C-Reactive Protein Concentrations in Hemodialysis Patients

Rashidi, Ali Akbar; Salehi, Masoud; Piroozmand, Ahmad; Sagheb, Mohammad Mehdi

doi:10.1053/j.jrn.2009.04.005

Cited by 49 publications

(32 citation statements)

References 19 publications

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“…This is consistent with previous findings that showed improvement of serum zinc concentrations in the HD population after zinc supplementation. 3,17 In this study, before zinc supplementation, serum leptin level in patients was 8.03±4.6 ng/mL, which was higher in females compared to males. This higher concentration of leptin in females agrees with previous research, 18 and similar to Aranha et al, who observed that low plasma zinc levels were negatively associated with high leptin levels in HD patients.…”

Section: Discussionmentioning

confidence: 51%

Effect of zinc supplementation on body mass index and serum levels of zinc and leptin in pediatric hemodialysis patients

Elshazly¹,

Ibrahim²,

El-Mashad³

et al. 2015

IJNRD

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Introduction Zinc is an essential trace element for human nutrition, and its deficiency is associated with anorexia, poor food efficiency, growth retardation, and impaired neurological and immune systems. The zinc-deficiency rate is particularly high in many disease states, such as with end-stage renal disease patients undertaking hemodialysis. The aim of this study was to determine the effect of zinc supplementation on body mass index (BMI) and serum levels of zinc and leptin in pediatric hemodialysis patients. Patients and methods This was a prospective clinical trial study in which 60 hemodialysis patients were randomly divided into two groups: group I received 50–100 mg zinc sulfate (equivalent to 11–22 mg elemental zinc) according to age, sex, and nutritional status of the child; and group II received placebo (cornstarch) twice daily for 90 days. Anthropometric measurements were taken, and serum zinc and leptin levels were determined by colorimetric test with 5-Br-3′-phosphoadenosine-5′-phosphosulfate and enzyme-linked immunosorbent assay, respectively, at days 0 and 90 of the study. Results Zinc supplementation resulted in a significant increase in mean serum zinc level and BMI. Serum leptin decreased significantly after supplementation in children under hemodialysis. A significant negative correlation was observed between serum zinc and leptin levels as a result of zinc supplementation. Conclusion There was an increase in serum zinc level and BMI and decreased serum leptin after zinc supplementation in children under hemodialysis.

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Section: Discussionmentioning

confidence: 51%

Effect of zinc supplementation on body mass index and serum levels of zinc and leptin in pediatric hemodialysis patients

Elshazly¹,

Ibrahim²,

El-Mashad³

et al. 2015

IJNRD

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“…3 Zinc supplementation may also decrease inflammation in HD patients. 6 In this study although zinc supplement did not have significant effect on plasma levels of ESR and ferritin as …”

Section: Dear Sirmentioning

confidence: 48%

“…6 Zinc deficiency in the Middle East area and Iran is estimated to be seen in around 30% of healthy persons. It is even more common in chronic medical conditions, for example, renal failure patients on dialysis.…”

Section: Dear Sirmentioning

confidence: 99%

Comment on:Does Zinc Supplementation Affect Inflammatory Markers in Hemodialysis Patients?

Roozbeh¹,

Pakfetrat²,

Jahromi³

et al. 2011

Renal Failure

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“…Por otro lado, el estudio de Rashidi y cols. 25 no reportó una diferencia estadísticamente significativa en los niveles de PCR al comparar la suplencia de zinc con placebo.…”

Section: Erc Con Falla Renalunclassified

Nutritional supplements in chronic kidney disease

Arreaza-Kaufman

Rodríguez

Tassinari

et al. 2016

RCN

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ResumenIntroducción: El estado nutricional de los pacientes con enfermedad renal crónica (ERC) influye sobre el progreso de la enfermedad y se asocia al incremento en el riesgo cardiovascular. Revisamos en la literatura el efecto de los suplementos nutricionales en estos pacientes. Métodos: Se realizó una búsqueda de la literatura en las bases de datos electrónicas Pubmed y Embase para encontrar estudios clínicos que relacionaran el efecto de los suplementos y/o complementos nutricionales con ERC. Resultados: De 353 artículos que resultaron inicialmente, se seleccionaron 26, de los cuales 23 fueron realizados en población con falla renal. En los pacientes con suplencia, se reportaron efectos como disminución en los niveles de homocisteína tras la administración de zinc, omega-3 y ácido fólico. Adicionalmente, se evidenció disminución en los metabolitos de estrés oxidativo. Con la terapia de suplementación con vitamina D se observó mejoría en el perfil lipídico y diminución en hemoglobina glicosilada y PCR. Discusión: Los suplementos y/o complementos nutricionales compuestos por probióticos, ácidos grasos de cadena larga (omega-3), proteí-nas, elementos de traza, antioxidantes y ácido fólico podrían ser de importancia en pacientes con ERC ante los efectos benéficos que han demostrado tener, por la reducción en la homocisteína y otros factores derivados del estrés oxidativo considerados marcadores de riesgo cardiovascular, o también por disminuirse la prevalencia de malnutrición en esta población. Los estudios sugieren que los suplementos y/o complementos nutricionales podrían retrasar el deterioro renal progresivo y reducir los marcadores de riesgo cardiovascular, principalmente en aquellos compuestos por omega-3.Palabras clave: Insuficiencia renal, suplementos dietarios, zinc, ácidos grasos, ácido fólico, proteínas.http://doi.org/10.22265/acnef.3.2.230 Abstract Introduction: The nutritional status of patients with chronic kidney disease (CKD) affects the progress of the disease and is associated with increased cardiovascular risk. We reviewed the literature in search of the effect of nutritional supplements in these patients. Methods: Our search included the electronic databases Pubmed and Embase and was structured to find clinical studies relating the effect of supplements and/or nutritional supplements with CKD. Results: In total the search resulted in 353 articles, 26 were selected, of which 23 were performed in people with kidney failure. In patients with supplements, effects such as decrease in homocysteine levels after administration of zinc, omega-3 and folic acid were reported. Additionally, reduction was observed in the metabolites of oxidative stress. In therapy with vitamin D supplementation resulted in improvements in the lipid profile and reduction in the levels of glycated hemoglobin and PCR. Discussion: Supplements and/or nutritional compliments with compounds probiotics, long chain fatty acids (omega-3), proteins, trace elements, antioxidants and folic acid; Could be relevant in patients with CKD...

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Effects of Zinc Supplementation on Serum Zinc and C-Reactive Protein Concentrations in Hemodialysis Patients

Cited by 49 publications

References 19 publications

Effect of zinc supplementation on body mass index and serum levels of zinc and leptin in pediatric hemodialysis patients

Effect of zinc supplementation on body mass index and serum levels of zinc and leptin in pediatric hemodialysis patients

Comment on:Does Zinc Supplementation Affect Inflammatory Markers in Hemodialysis Patients?

Nutritional supplements in chronic kidney disease

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