Effects of zinc supplementation on glycemic control and oxidative stress in experimental diabetes: A systematic review

Anti-Glycation Properties of Zinc-Enriched Arthrospira platensis (Spirulina) Contribute to Prevention of Metaflammation in a Diet-Induced Obese Mouse Model

“…It must be acknowledged that the spirulina we tested has been enriched in zinc which may further strengthen its beneficial effects. In fact, zinc acts on oxidative stress, being both an essential player in the process of antioxidant enzymes synthesis and an enzymatic catalyzer [ 45 ]. There is evidence that imbalances in zinc homeostasis are frequent in metabolic disorders [ 46 , 47 ] and blood zinc concentrations were found to be significantly decreased in obese patients [ 46 , 48 ].…”

“…There is evidence that imbalances in zinc homeostasis are frequent in metabolic disorders [ 46 , 47 ] and blood zinc concentrations were found to be significantly decreased in obese patients [ 46 , 48 ]. Zinc supplementation in experimental diabetes has shown positive results improving glucose homeostasis [ 45 ]. However, there are still contrasting data about the clinical efficacy of zinc supplementation, with human trials on obese and diabetic patients reporting either positive outcomes or a lack of efficacy [ 49 , 50 , 51 , 52 ].…”

Zinc supplementation alleviates oxidative stress to inhibit chronic gastritis via the ROS/NF-κB pathway in a mouse model

“…Many studies have demonstrated the benefits of zinc supplementation in treating diseases caused by oxidative stress or related to inflammation, which to some extent provides new ideas for the treatment and prevention of inflammation in the body. 27 ROS are important indicators of oxidative stress, and their levels are generally stable in the body. 28 The ROS oxidative stress signaling pathway and antioxidant signaling pathway are the mechanisms by which cells regulate and balance their resistance to oxidative stress-induced oxidative damage.…”

Anti-diabetic effect of Ornithogalum caudatum Jacq. polysaccharides via the PI3K/Akt/GSK-3β signaling pathway and regulation of gut microbiota

“…A consistently high blood glucose level is associated with the generation of reactive oxygen species, which may cause oxidative damage to the pancreas and liver [ 18 ]. In the present study, OCPs treatment increased the activity of CAT, SOD, and GSH-Px in the liver; additionally, histopathological analysis showed that OCPs ameliorated diabetes-induced injuries in the liver and pancreas.…”