Effects of Zizyphus lotus L. (Desf.) polyphenols on Jurkat cell signaling and proliferation

Abdoul-Azize, Souleymane; Bendahmane, Malika; Hichami, Aziz; Dramane, Gado; Simonin, A.; Benammar, Chahid; Sadou, Hassimi; Akpona, Simon; Boustani, E. El; Khan, Naim Akhtar

doi:10.1016/j.intimp.2012.11.013

Cited by 22 publications

(18 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…which have been supposed to be responsible for most of its health benefits such as hypoglycemic, gastroprotective, immunomodulatory, and antioxidant properties [14, 21, 22]. In this respect, the fruit of Z. lotus is a valuable source of nutrients as well as antioxidant [4, 21, 23, 24], antimicrobial, and antifungal [13, 25], immunosuppressive [14], anti-inflammatory [26], and antiulcerogenic [21, 27] compounds. Z. lotus leaves contain different carbohydrates and dammarane saponins notably jujuboside B, three jujubogenin glycosides, and jujubasaponine IV [20].…”

Section: General Compound Content Of Z Lotusmentioning

confidence: 99%

“…Interestingly, our previous studies demonstrated that Z. lotus polyphenols also modulate human immune cell signaling and exert immunosuppressive effects [14]. As shown in Figure 3, in human T cells, Z. lotus polyphenols (ZLP) upregulate thapsigargin- (TG-, inhibitor of Ca 2+ -ATPase) mediated calcium signaling at endoplasmic reticulum level, modulate plasma membrane, and, thus, block the entry of ions, decrease ERK1 and ERK2 activation, diminish cell proliferation and IL-2 expression by arresting S cell cycle, and increase intracellular acidification in dose-dependent manner [14]. ZLP alone do not induce elevation of intracellular calcium concentration, [Ca 2+ ] i , in these cells.…”

Section: Z Lotus Phenolic Compounds and Immune System: Mechanismsmentioning

confidence: 99%

“…In herbal medicine, the properties of bioactive compounds from plants depend on the part of the plant concerned (root, leaf stalk, pulp, or fruit) and the type of extract used. Z lotus is known for its high content in polyphenols exhibiting antioxidant and antimicrobial, immunomodulatory properties [13, 14]. Importantly, others biologically active molecules, particularly cyclopeptide alkaloids, termed lotusines [15–17], dammarane saponins [12], and various flavonoids [18] have been isolated from this shrub, along with polyunsaturated fatty acids (oleic acid and linoleic acid), high carbohydrate, and fibers which are abundant in seed extracts and endowed with antiulcerogenic and antioxidants effects [11, 19].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Potential Benefits of Jujube (Zizyphus Lotus L.) Bioactive Compounds for Nutrition and Health

Abdoul-Azize

2016

Journal of Nutrition and Metabolism

Self Cite

View full text Add to dashboard Cite

Zizyphus lotus, belonging to the Rhamnaceae family, is a deciduous shrub which generally grows in arid and semiarid regions of the globe. In traditional medicine, Z. lotus is used as antidiabetes, sedative, bronchitis, and antidiarrhea by local populations. Recently, several scientific reports for health benefit and nutritional potential of bioactive compounds from this jujube have been reported. This plant is rich in polyphenols, cyclopeptide alkaloids, dammarane saponins, vitamins, minerals, amino acids, and polyunsaturated fatty acids. These identified compounds were supposed to be responsible for most of Z. lotus biologically relevant activities including antimicrobial, anti-inflammatory, hypoglycemic, antioxidant, and immunomodulatory effects. The aim of the present review was to give particular emphasis on the most recent findings on biological effects of the major groups of Zizyphus lotus components and their medical interest, notably for human nutrition, health benefit, and therapeutic impacts.

show abstract

Section: General Compound Content Of Z Lotusmentioning

confidence: 99%

Section: Z Lotus Phenolic Compounds and Immune System: Mechanismsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Potential Benefits of Jujube (Zizyphus Lotus L.) Bioactive Compounds for Nutrition and Health

Abdoul-Azize

2016

Journal of Nutrition and Metabolism

Self Cite

View full text Add to dashboard Cite

show abstract

“…Moreover, analgesic and anti‐ulcerogenic activities of this plant have also been demonstrated (Wahida, Abderrahman, & Nabil, ). Several biologically active molecules, including polyphenols, cyclopeptide alkaloids, and dammarane saponins, have been isolated from Zl (Abdoul‐Azize et al, ). It has been reported that high antioxidant properties of Zl fruit were attributed to the presence of phenolic compounds including gallic acid, syringic acid, catechin, quercetin, and kaempferol as identified by the HPLC system (Hammi et al, ).…”

Section: Introductionmentioning

confidence: 99%

Antiinflammatory and antioxidant activities of a polyphenol‐rich extract fromZizyphus lotusL fruit pulp play a protective role against obesity

et al. 2018

Self Cite

View full text Add to dashboard Cite

Zizyphus lotus (Zl) is used widely as a source of food and for the treatment of various ailments. Therefore, we investigated the biological activities of Zl against obesity and related disorders. Hence, male Wistar rats received either control diet, high fat diet (HFAD), or HFAD supplemented with the Zl pulp (HFADP) for 14 weeks. RAW 264.7 cells were used for the determination of antiinflammatory activities in vitro. It was observed that HFDP resulted in significantly reduced weight, blood sugar, and oxidative stress than HFAD. In addition, Zl extract co‐treatment with LPS reduced the mRNA expression of MCP‐1, pro‐inflammatory cytokines (IL‐6, TNF‐α), and increased the level of IL‐10, an antiinflammatory cytokine, in LPS‐stimulated RAW 264.7 cells. Moreover, nitric oxide synthesis and the expression of iNOS were decreased by Zl extract in RAW 264.7 cells. Zl extract also possessed a significant antioxidant capacity and ferric‐reducing power. Our results validate the traditional use of Zl. Practical applications Zizyphus lotus is commonly used as food in different countries and is easily available. Scientific validation of the traditional use of plants can be significant in the prevention and treatment of different disorders. Naturally occurring products are generally safe to use, have fewer side effects, and can be self‐administered. Hence, specialized health‐care supervision is not necessary. Our study supports the traditional use of Zizyphus lotus to prevent and decrease obesity and related disorders.

show abstract

“…), known as jujube, is abundantly present in the Mediterranean region, including Libya, Morocco, Algeria, and southern European countries like Spain, Sicily, Greece, and Cyprus. Digestive pathologies, weakness, obesity, urinary troubles, diabetes, skin infections, fever, diarrhea, and insomnia are some disorders that can be treated with some parts of Zizyphus (Abdoul‐Azize et al, ). “Sedra” is the local name of Z. lotus in Algeria (Benammar et al, ), where it is used in for its anti‐diabetic, sedative and hypoglycaemic activities (Anand, Singh, Grand, Chandan, & Gupta, ).…”

Section: Introductionmentioning

confidence: 99%

In vivo wound healing potential and HPLC-PDA-ESI-MS profiling ofZizyphus lotusL. (Desf.) leaves methanol extract

et al. 2018

View full text Add to dashboard Cite

This study was performed to evaluate the wound healing potential and antioxidant effect of methanol extract of Zizyphus lotus leaves (MZL), and to identify its phenolic profile by HPLC‐PDA‐ESI‐MS. Wound healing activity was assessed in vivo using excision model. Biochemical and histopathological analyses were conducted. In vitro antioxidant potential of MZL was tested using 2,2‐diphenyl‐1‐picrylhydrazyl and β‐carotene bleaching methods. HPLC‐PDA‐ESI‐MS was used for the phenolic profiling. Animals treated with MZL ointment showed a significant reduction in epithelialization time and high contraction rate compared to controls. Proteins, hydroxyproline, and hexosamines contents of ointment‐treated animals were higher than controls. Marked cross‐linking of collagen fibers and lack of inflammatory cells were observed in the granulation tissue of the ointment‐treated animals. Chemical profiling of MZL revealed that quercetin‐3‐O‐rutinoside and catechin are the major constituents. Phenolic compounds of the methanol extract of Zizyphus lotus leaves may be engaged in the acceleration of the healing process activity. Practical application In Mediterranean region, like Algeria, Zizyphus lotus is used in nutrition, health, and cosmetics. Several parts of this plant are employed to treat urinary troubles, diabetes, skin infections, fever, diarrhea, insomnia, bronchitis, and hypoglycemia. There is no scientific paper investigating the phenolic composition of Z. lotus leaves using a mass spectrometry coupled high‐performance liquid chromatography, as well as examining their wound healing potential. Results from this study revealed the presence of many flavonoids exhibiting important antioxidant and wound healing potentials through specific mechanisms. Z. lotus leaves are a source of pharmacologically active compounds with benefits for human nutrition, health‐promoting, and disease preventing.

show abstract

Effects of Zizyphus lotus L. (Desf.) polyphenols on Jurkat cell signaling and proliferation

Cited by 22 publications

References 50 publications

Potential Benefits of Jujube (Zizyphus Lotus L.) Bioactive Compounds for Nutrition and Health

Potential Benefits of Jujube (Zizyphus Lotus L.) Bioactive Compounds for Nutrition and Health

Antiinflammatory and antioxidant activities of a polyphenol‐rich extract fromZizyphus lotusL fruit pulp play a protective role against obesity

In vivo wound healing potential and HPLC-PDA-ESI-MS profiling ofZizyphus lotusL. (Desf.) leaves methanol extract

Contact Info

Product

Resources

About