2017
DOI: 10.1016/j.bbr.2016.12.014
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Effects of ZnSO4-induced peripheral anosmia on zebrafish behavior and physiology

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Cited by 16 publications
(11 citation statements)
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“…In contrast, our pioneer study demonstrated, for the first time, that adult zebrafish exposed to ZnCl 2 had reduced locomotor behavior, average speed, entries to the upper zone, and total distance traveled. The average angular velocity and meandering of the fishes increased following 1 ppm ZnCl 2 treatment compared to the control group, which was consistent with previous studies on other heavy-metal toxicity in zebrafish [ 53 ]. According to the literature research, we hypothesize that ZnCl 2 exposure triggered an increase in muscle cortisol and reactive oxygen species (ROS) levels in the brains of zebrafish, which likely contributed to a stress-elicited reduction in locomotor activity [ 54 ].…”
Section: Discussionsupporting
confidence: 91%
“…In contrast, our pioneer study demonstrated, for the first time, that adult zebrafish exposed to ZnCl 2 had reduced locomotor behavior, average speed, entries to the upper zone, and total distance traveled. The average angular velocity and meandering of the fishes increased following 1 ppm ZnCl 2 treatment compared to the control group, which was consistent with previous studies on other heavy-metal toxicity in zebrafish [ 53 ]. According to the literature research, we hypothesize that ZnCl 2 exposure triggered an increase in muscle cortisol and reactive oxygen species (ROS) levels in the brains of zebrafish, which likely contributed to a stress-elicited reduction in locomotor activity [ 54 ].…”
Section: Discussionsupporting
confidence: 91%
“…Behavioral tests have been used in neuroscience, neuropharmacology, and neurotoxicity fields to access numerous CNS disorders. This tool can help to elucidate the mechanisms involved in pathologies or injuries caused by chemical exposure and may be conducted with adults ( Abreu et al, 2017 ; Kundap et al, 2017 ; Genario et al, 2020 ; Müller et al, 2020 ) or larvae zebrafish ( Vitebsky et al, 2005 ; Krishnan et al, 2014 ; Ko et al, 2019 ), and may use the exploratory pattern to stimuli, such as light vibration and odorants exposure ( Kalueff et al, 2013 ). In this context, many protocols have been developed and cataloged over the past decade; for instance, Kalueff et al (2013) clustered 190 distinct behavioral phenotypes that include anxiety-like, freeze, spasm behaviors, and seizures.…”
Section: Evaluation Of Sars-cov-2 Neurologic Alterations Through Zebrafish’s Behaviormentioning
confidence: 99%
“…In the light of COVID-19 CNS alterations, anosmia may be evaluated in zebrafish at the behavioral level. In this direction, assessing locomotor activity with adults or larvae can be used to evaluate the olfactory system function ( Krishnan et al, 2014 ; Abreu et al, 2017 ). It has been described that anosmia induced by lidocaine and ZnSO4 promoted anxiety-like behaviors in zebrafish ( Abreu et al, 2016 , 2017 ).…”
Section: Evaluation Of Sars-cov-2 Neurologic Alterations Through Zebrafish’s Behaviormentioning
confidence: 99%
“…In zebrafish, it produces substantial damage to the olfactory sensory epithelium with a marked decrease in ciliated OSNs and an associated reduction of detection of bile salts and amino acids, to a lesser extent. Additionally, the anosmia produced by Zn treatment induces a stress response accompanied by anxiety-like behaviors and a reduction in locomotor activity [19,88,133].…”
Section: The Olfactory System Of Zebrafish As a Model Of Neuroplasmentioning
confidence: 99%
“…These studies clearly show that exposure to waterborne heavy metals produce significant damage of the olfactory organ leading to olfactory dysfunction in zebrafish, with bile salt-sensing ciliated OSNs presenting the most susceptibility to the effects of some of these neurotoxicant agents (Figure 3A, Table 1). The functional consequences of this metal-induced olfactory impairment are several alterations in odor-mediated behaviors critical for survival (Figure 3C) [19,88,115,122,133].…”
Section: The Olfactory System Of Zebrafish As a Model Of Neuroplasmentioning
confidence: 99%