Effects of Zoledronic Acid on Orthodontic Tooth Movement in Rats

Brunet, Marcel Durante; Araújo, Cristiano Miranda de; Johann, Aline Cristina Batista Rodrigues; Camargo, Elisa Souza; Tanaka, Orlando Motohiro; Guariza, Odilon

doi:10.1590/0103-6440201600966

Cited by 15 publications

(9 citation statements)

References 25 publications

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“…After screening, 908 articles were discarded because they did not fulfill the inclusion/exclusion criteria based on the title and abstract. The remaining 16 articles were read entirely, of which nine were excluded as they involved systemic administration of bisphosphonates[ 13 14 19 20 21 22 23 24 25 ] Table 1 . Finally, after careful consideration, seven papers that met our inclusion criteria were included in the qualitative analysis.…”

Section: Resultsmentioning

confidence: 99%

Effect of local administration of bisphosphonate on orthodontic anchorage – A systematic review of animal studies

Harikrishnan¹,

Navaneethan²

2022

Journal of Orthodontic Science

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BACKGROUND: Pharmacological means of anchorage control can improve patient compliance. Bisphosphonates could be helpful in orthodontic anchorage control if their actions could be localized to limit (or control) unwanted tooth movement while not interfering with the desired tooth movement. OBJECTIVE: This systematic review aimed to examine and evaluate the quality of all animal studies that reported the effect of locally administered bisphosphonate on limiting orthodontic tooth movement. DATA SOURCES: An electronic search was conducted in the PubMed-Medline, Scopus, Google Scholar, and Cochrane databases till May 2022, using the keywords anchorage, anchorage loss, molar movement, posterior tooth movement, incisor movement, incisor retraction, anterior retraction, unwanted tooth movement, tooth displacement, tooth movement forward, bisphosphonate, local bisphosphonate administration, bisphosphonate injection, and bbisphosphonate vestibular induction. Only studies involving localized bisphosphonate administration for anchorage purposes were taken into account. DATA SELECTION: Animal studies that simulated orthodontic tooth movement after localized injection of bisphosphonate and evaluated the rate of tooth movement were included in the review. DATA EXTRACTION AND ANALYSIS: The quality of the studies was assessed by using ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments). Bias in the studies was analyzed by SYRCLE's tool (Systematic Review Centre for Laboratory Animal Experimentation) for risk of bias. RESULTS: The search strategy yielded 925 titles. After screening, 908 articles were discarded because they did not fulfill the inclusion/exclusion criteria based on the title and abstract. The remaining 16 articles were read entirely, of which nine were excluded as they involved systemic administration of bisphosphonates. Finally, after careful consideration, seven papers that met our inclusion criteria were included in the qualitative analysis. The majority of studies were assessed to have an uncertain risk of bias, with just one deemed low risk of bias. CONCLUSION: This systematic review found that bisphosphonates limit orthodontic tooth movement around the application site without affecting adjacent sites. More potent bisphosphonates in smaller doses or less potent bisphosphonates in higher frequencies have been proposed to improve outcomes. However, the data quality is insufficient to recommend a protocol for bisphosphonate administration for anchoring control. Long-term studies evaluating various types, frequencies, and dosages of bisphosphonates are required to clarify the effects on orthodontic tooth movement. REGISTRATION NUMBER FOR PROSPERO: CRD42021224033

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Section: Resultsmentioning

confidence: 99%

Effect of local administration of bisphosphonate on orthodontic anchorage – A systematic review of animal studies

Harikrishnan¹,

Navaneethan²

2022

Journal of Orthodontic Science

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“…The distance between the first upper right molar and the upper central incisor on the same side was measured using a digital calliper positioned in the most cervical point of the tooth (mesial molar and incisor palatal) to standardizing measurements. The measurement was performed by two operators, and when measurements varied, a third measurement was performed for confirmation 26 …”

Section: Methodsmentioning

confidence: 99%

“…The measurement was performed by two operators, and when measurements varied, a third measurement was performed for confirmation. 26…”

Section: Measurement Of Interdental Space (Is)mentioning

confidence: 99%

Intense orthodontic force induces the three dental pulp nitric oxide synthase isoforms and leads to orofacial discomfort in rats

Sobrinho

Aguiar

Machado

et al. 2022

Orthod Craniofacial Res

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Objective The objective of this study was to evaluate the role of nitric oxide synthase (NOS) isoforms influence during tooth movement with different forces. Settings and sample population 100 male Wistar rats (n = 10/group) were divided into a Sham group (animals not submitted to device installation nor Induced Toot Movement [ITM]), Negative Control Group (NCG) (animals submitted to device installation but not to ITM) and three experimental groups (F1, F2 and F3) (submitted to ITM with forces of 25, 50 and 100 gF respectively). Materials and methods A daily count of biting and scratching on the vibrissae and the Grimace scale were applied. After 4 (D4) and 11 (D11) days, the molar diastema was measured, and the animals were euthanized for histological (vascular parameters) and immunohistochemistry (iNOS, eNOS and nNOS) in the dental pulp. Results On D4, there was significant movement in the F3 group (P = .001) and on D11 in F1, F2 and F3 (P < .001). The number of bites (P < .001) and scratching (P = .006) was higher in F2‐F3, and F3 had higher Grimace scores (P < .001) and weight loss (P < .001). At D4, there was an increase in pulp ectasia in F2‐F3 (P = .021) and a reduction in the number of vessels in F3 (P = .005). In D4 and D11, there was a significant increase in immunostaining for iNOS and eNOS in F1 (P = .025 and P < .001 respectively) and F2 (P = .007 and P < .001 respectively). At D4, F2 and F3 showed higher immunostaining for nNOS (P = .027). Conclusion Thus, IDM induced inflammatory changes in the dental pulp reflecting in force‐dependent pain/suffering signs.

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“…Os bisfosfonatos são medicamentos utilizados desde a década de 60 para o tratamento de inúmeras patologias ósseas, dentre as quais se destacam: metástases ósseas, câncer de pulmão, mieloma múltiplo e o controle de doenças do metabolismo do cálcio (DE MORAES et al, 2013). Os bisfosfonatos participam no processo do metabolismo ósseo e interferem na função de osteoblastos e osteoclastos, além de produzir efeitos inibitórios nos mediadores inflamatórios durante o processo de cicatrização de lesões ósseas (BRUNET et al, 2016). De acordo com Ribeiro et al (2011) o uso destes fármacos tem aumentado tornando-se a droga mais prescrita no mundo para o tratamento da osteoporose.…”

Section: Bisfosfonatosunclassified

Avaliaçâo Da Satisfação Dos Pacientes Atendidos Na Clínica De Prótese Dental Ii Do Curso De Odontologia Da Universidade Estadual De Ponta Grossa No Paraná

Pinheiro¹,

Samra²

2021

Odontologia: Da Dentística À Traumatologia

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Direitos para esta edição cedidos à Atena Editora pelos autores. Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição-Não-Comercial-NãoDerivativos 4.0 Internacional (CC BY-NC-ND 4.0).O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, inclusive não representam necessariamente a posição oficial da Atena Editora. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais. Todos os manuscritos foram previamente submetidos à avaliação cega pelos pares, membros do Conselho Editorial desta Editora, tendo sido aprovados para a publicação com base em critérios de neutralidade e imparcialidade acadêmica.A Atena Editora é comprometida em garantir a integridade editorial em todas as etapas do processo de publicação, evitando plágio, dados ou resultados fraudulentos e impedindo que interesses financeiros comprometam os padrões éticos da publicação. Situações suspeitas de má conduta científica serão investigadas sob o mais alto padrão de rigor acadêmico e ético.

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Effects of Zoledronic Acid on Orthodontic Tooth Movement in Rats

Cited by 15 publications

References 25 publications

Effect of local administration of bisphosphonate on orthodontic anchorage – A systematic review of animal studies

Effect of local administration of bisphosphonate on orthodontic anchorage – A systematic review of animal studies

Intense orthodontic force induces the three dental pulp nitric oxide synthase isoforms and leads to orofacial discomfort in rats

Avaliaçâo Da Satisfação Dos Pacientes Atendidos Na Clínica De Prótese Dental Ii Do Curso De Odontologia Da Universidade Estadual De Ponta Grossa No Paraná

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