Effects of α-galactosidase supplementation on nutrient digestibility, growth performance, intestinal morphology and digestive enzyme activities in weaned piglets

Shang, Qinghui; Ma, Xi; Li, M.; Zhang, L.H.; Hu, Jie; Piao, Xiangshu

doi:10.1016/j.anifeedsci.2017.11.008

Cited by 26 publications

(15 citation statements)

References 37 publications

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“…Intestinal villi are the site where most of the nutrients are absorbed, and their height is indicative of the absorptive capacity of intestinal mucosa [ 42 ]. Crypts are known as the villus factory where new epithelial cells are produced, and their depth reflects the rate of tissue turnover to ensure renewal of the villus [ 43 ]. The villus height to crypt depth ratio is a useful criterion for estimating the absorptive capacity of the small intestine [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

The Impact of Wheat Bran on the Morphology and Physiology of the Gastrointestinal Tract in Broiler Chickens

Shang

Liu

et al. 2020

Animals

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There is increasing evidence showing that moderate amounts of insoluble dietary fiber can improve nutrient utilization by positively influencing the physiology of the gastrointestinal tract. The present study was conducted to investigate the effects of wheat bran as a source of insoluble fiber on nutrient digestibility, serum antioxidant status, gastrointestinal development, digestive enzyme activities and intestinal morphology in broiler chickens. A total of 96 one-day-old male Arbor Acre broiler chickens were assigned to two treatments with six replicate cages per treatment and eight birds per replicate for 42 d. Dietary treatments consisted of the control group (CON, control diet) and wheat bran group (WB, 30 g/kg wheat bran). Inclusion of WB increased (p < 0.05) the digestibility of dry matter, organic matter, gross energy and crude protein on Day 42. Birds fed WB had lower (p < 0.05) serum total cholesterol concentration on Day 21, and lower (p < 0.05) serum concentrations of low-density lipoprotein, total cholesterol and total triglyceride on Day 42. Inclusion of WB increased (p < 0.05) serum glutathione peroxidase activity on Day 21 and superoxide dismutase activity on Day 42, but tended (p = 0.07) to decrease serum malondialdehyde concentration on Day 21, and significantly decreased (p < 0.05) serum malondialdehyde concentration on Day 42. Birds fed WB had a greater (p < 0.05) relative weight of gizzard on both Day 21 and 42. Inclusion of WB increased (p < 0.05) activities of amylase and trypsin in pancreas and jejunal mucosa on Day 21, and increased (p < 0.05) amylase activity in pancreas and jejunal mucosa. Birds fed WB had greater (p < 0.05) villus height and villus height to crypt depth ratio in jejunum and ileum on Day 42. In conclusion, supplementation of 30 g/kg WB enhanced nutrient digestibility by improving antioxidant status, gizzard development, intestinal digestive enzyme activities and morphology of broilers.

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Section: Discussionmentioning

confidence: 99%

The Impact of Wheat Bran on the Morphology and Physiology of the Gastrointestinal Tract in Broiler Chickens

Shang

Liu

et al. 2020

Animals

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“…The chemo-enzymatic route for the synthesis of Boc-(R)-3-amino-4-(2,4,5-trifluorophenyl)-butyric acid (adopted from Ref. [82]) present in these foods, which when remain undigested cause the discomfort, probably due to the bacterial fermentation of the undigested sugars [113]. Now-a-days α-galactosidase and lactase are available as a number of ready to use supplements.…”

Section: Scheme 11mentioning

confidence: 99%

Enzymes for pharmaceutical and therapeutic applications

Meghwanshi

Kaur

Verma

et al. 2020

Biotech and App Biochem

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Enzymes are highly efficient and selective biocatalysts, present in the living beings. They exist in enormous varieties in terms of the types of reactions catalyzed by them for instance oxidation–reduction, group transfers within the molecules or between the molecules, hydrolysis, isomerization, ligation, bond cleavage, and bond formation. Besides, enzyme based catalyses are performed with much higher fidelity, under mild reaction conditions and are highly efficient in terms of number of steps, giving them an edge over their chemical counter parts. The unique characteristics of enzymes makes them highly applicable fora number of chemical transformation reactions in pharmaceutical industries, such as group protection and deprotection, selective acylation and deacylation, selective hydrolysis, deracemization, kinetic resolution of racemic mixtures, esterification, transesterification, and many others. In this review, an overview of the enzymes, their production and their applications in pharmaceutical syntheses and enzyme therapies are presented with diagrams, reaction schemes and table for easy understanding of the readers.

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“…For instance, the addition of this molecule to pig diets influences intestinal architecture by increasing villi heights, villus height/crypt depth ratio, and villi surface area. The increased height of the villi leads to an increased digestive and absorptive function of the intestine due to an increased absorptive surface area, expression of brush border enzymes, and nutrient transport systems [ 93 ].…”

Section: Functional Oligosaccharidesmentioning

confidence: 99%

The Influences of Soybean Agglutinin and Functional Oligosaccharides on the Intestinal Tract of Monogastric Animals

Pan

Farouk

Zhao

et al. 2018

IJMS

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Soybean agglutinin (SBA) is a non-fiber carbohydrate-related protein and the main anti-nutritional factor that exists in soybean or soybean products. SBA possesses a specific binding affinity for N-glyphthalide-d-galactosamine or galactose and has a covalently linked oligosaccharide chain. SBA mediates negative effects on animal intestinal health by influencing the intestinal structure, barrier function, mucosal immune system, and the balance of the intestinal flora. Functional oligosaccharides are non-digestible dietary oligosaccharides that are commonly applied as prebiotics since the biological effects of the functional oligosaccharides are to increase the host health by improving mucosal structure and function, protecting the integrity of the intestinal structure, modulating immunity, and balancing the gastrointestinal microbiota. The purpose of this review is to describe the structure and anti-nutritional functions of SBA, summarize the influence of SBA and functional oligosaccharides on the intestinal tract of monogastric animals, and emphasize the relationship between SBA and oligosaccharides. This review provides perspectives on applying functional oligosaccharides for alleviating the anti-nutritional effects of SBA on the intestinal tract.

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Effects of α-galactosidase supplementation on nutrient digestibility, growth performance, intestinal morphology and digestive enzyme activities in weaned piglets

Cited by 26 publications

References 37 publications

The Impact of Wheat Bran on the Morphology and Physiology of the Gastrointestinal Tract in Broiler Chickens

The Impact of Wheat Bran on the Morphology and Physiology of the Gastrointestinal Tract in Broiler Chickens

Enzymes for pharmaceutical and therapeutic applications

The Influences of Soybean Agglutinin and Functional Oligosaccharides on the Intestinal Tract of Monogastric Animals

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