Effects of α-linolenic acid supplementation in perilla oil on collagen-epinephrine closure time, activated partial thromboplastin time and Lp-PLA 2 activity in non-diabetic and hypercholesterolaemic subjects

Kim, Minkyung; Lee, Young Ju; Lee, Sung Pyo; Kim, Tae Su; Yang, Hye Jeong; Kwon, Dae Young; Lee, Sang Hyun; Lee, Jong Ho

doi:10.1016/j.jff.2016.02.026

Cited by 23 publications

(16 citation statements)

References 37 publications

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“…Furthermore, we found a positive correlation between the reduction in ox-LDL level and total Lp-PLA2 mass in the ALA group. Such a positive correlation has also been observed in other clinical studies [53][54][55].…”

Section: Discussionsupporting

confidence: 84%

The Beneficial Effects of Alpha Lipoic Acid Supplementation on Lp-PLA2 Mass and Its Distribution between HDL and apoB-Containing Lipoproteins in Type 2 Diabetic Patients: A Randomized, Double-Blind, Placebo-Controlled Trial

Baziar

Nasli‐Esfahani²,

Djafarian

et al. 2020

Oxidative Medicine and Cellular Longevity

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Lipoprotein-associated phospholipase A 2 (Lp-PLA2) is a new specific vascular inflammation biomarker that is carried by the lipoproteins in the blood and plays a prominent role in the pathogenesis of atherosclerosis. Increased Lp-PLA2 levels and impaired Lp-PLA2 distribution across high-density lipoprotein (HDL) and non-HDL lipoproteins have been reported in diabetic patients, which is associated with the increase in cardiovascular disease (CVD) risk. This study is aimed at investigating the effect of alpha lipoic acid (ALA), as an antioxidant with potential cardioprotective properties, on the Lp-PLA2 mass and its distribution in diabetic patients. In a double-blind, randomized, placebo-controlled clinical trial, seventy diabetic patients were randomly allocated to ALA (1200 mg ALA as two 600 mg capsules/day) and placebo (two maltodextrin capsules/day) groups. The serum levels of total Lp-PLA2 mass, HDL-Lp-PLA2, oxidized low-density lipoproteins (ox-LDL), apolipoprotein A1 (apo A1), lipid profiles, fasting blood sugar (FBS), and insulin were measured, and apolipoprotein B-(apoB-) associated Lp-PLA2 and homeostasis model of assessment index (HOMA-IR) were calculated at the baseline and after 8 weeks of intervention. ALA significantly decreased the ox-LDL, total Lp-PLA2 mass, apoB-associated Lp-PLA2, and percent of apoB-associated Lp-PLA2 and triglyceride and increased the percent of HDL-Lp-PLA2 compared with the placebo group but had no significant effect on HDL-Lp-PLA2 mass, apo A1, lipid profiles, and glycemic indices. There was a positive correlation between the reduction in the ox-LDL level and total Lp-PLA2 mass in the ALA group. In conclusion, ALA may decrease the CVD risk by reducing the ox-LDL and Lp-PLA2 mass and improving the Lp-PLA2 distribution among lipoproteins in type 2 diabetic patients.

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Section: Discussionsupporting

confidence: 84%

The Beneficial Effects of Alpha Lipoic Acid Supplementation on Lp-PLA2 Mass and Its Distribution between HDL and apoB-Containing Lipoproteins in Type 2 Diabetic Patients: A Randomized, Double-Blind, Placebo-Controlled Trial

Baziar

Nasli‐Esfahani²,

Djafarian

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…Plasma adiponectin concentrations were measured using a human adiponectin enzyme‐linked immunosorbent assay kit (B‐Bridge International Inc, Sunnyvale, California), and absorbance values were recorded (Wallac Victor2 multilabel counter, Perkin Elmer Life Sciences, Turku, Finland). The detailed procedures for measuring MDA, ox‐LDL, and 8‐epi‐PGF 2α were presented in our previous studies …”

Section: Methodsmentioning

confidence: 99%

Weighting approaches for a genetic risk score and an oxidative stress score for predicting the incidence of obesity

Park

Yoo

Jee

et al. 2019

Diabetes Metabolism Res

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Background:We aimed to predict the incidence of obesity in a Korean population using a genetic risk score (GRS) constructed with obesity-related single nucleotide polymorphisms (SNPs) along with an oxidative stress score (OSS). Methods:A total of 9460 Korean subjects and 356 974 SNPs were included. The GRS was constructed using three significant obesity-related SNP loci, and the OSS was calculated with three reliable oxidative stress biomarkers. Results:The GRS showed a more significant association with increased obesity (OR = 2.879) than did individual SNPs after adjusting for age and sex. Three oxidative stress biomarkers, including malondialdehyde, oxidized low-density lipoprotein, and 8-epiprostaglandin F 2α , showed significantly high levels in the obese group. The OSS, which was the sum of each oxidative stress biomarker score, showed a markedly high association with the incidence of obesity, with an OR of 3.213. Based on the results of the regression tests and a receiver-operating characteristic (ROC) curve analysis, we found that HOMA-IR, high-sensitivity C-reactive protein (hs-CRP), the GRS, and the OSS were the most relevant factors for the increased risk of obesity and were significantly associated with the incidence of obesity. The area under the ROC curve was improved when the GRS was added to the model (from 74.2% to 75.1%). Conclusions:We first identified that subjects with an obesity GRS and a high OSS might have a higher risk of obesity. Our findings and weighting approaches were effective in predicting the incidence of obesity; furthermore, the GRS is a relevant factor that significantly predicts the risk of obesity. K E Y W O R D Sgenetic risk score, Korean population, obesity, oxidative stress score, prediction

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“…Detailed information on the clinical and biochemical assessments is provided elsewhere [7]. The body weight, height, and waist circumference were measured, and the BMI was calculated in units of kilograms per square meter (kg/m 2 ).…”

Section: Methodsmentioning

confidence: 99%

“…Blood samples were collected following an overnight fast of at least 12 hours. The levels of fasting triglycerides, total high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, glucose, insulin, and oxidized LDL (ox-LDL) were measured as previously described [7]. Insulin resistance (IR) was determined by the homeostasis model assessment (HOMA) using the following equation: HOMA-IR = [fasting insulin (μIU/mL) × fasting glucose (mmol/L)] / 22.5.…”

Section: Methodsmentioning

confidence: 99%

Effects of overweight and the PLA2G7 V279F polymorphism on the association of age with systolic blood pressure

Kim

Yoo

et al. 2017

PLoS ONE

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This prospective study aimed to determine the effects of the persistence of overweight for three years and the PLA2G7 V279F polymorphism, as well as the interaction between these factors, on the association of age with blood pressure (BP). Healthy middle-aged subjects with normotensive BP were divided into the normal-weight and overweight groups. The PLA2G7 V279F genotype, BP, lipoprotein-associated phospholipase A2 (Lp-PLA2) activity, and oxidized low-density lipoprotein (ox-LDL) were determined. Lp-PLA2 activity was lower in the F allele subjects (n = 111) than in those with the VV genotype (n = 389). The overweight individuals with the F allele had lower Lp-PLA2 activity and ox-LDL at both baseline and after three years and lower systolic and diastolic BP and LDL cholesterol after three years compared with those with the VV phenotype. After three years, the overweight subjects with the VV phenotype exhibited greater increases in Lp-PLA2 activity, systolic BP, and ox-LDL than those with the F allele and normal-weight subjects with the VV phenotype. A multivariate analysis revealed that the PLA2G7 V279F genotype, baseline BMI, changes in Lp-PLA2 activity and ox-LDL remained independently and positively associated with changes in systolic BP. The simultaneous presence of the PLA2G7 279VV genotype and persistence of overweight synergistically increases the risk for hypertension, whereas lower Lp-PLA2 activity in PLA2G7 279F allele carriers might offer certain protection against hypertension, even in individuals who have been overweight for over three years.

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Effects of α-linolenic acid supplementation in perilla oil on collagen-epinephrine closure time, activated partial thromboplastin time and Lp-PLA 2 activity in non-diabetic and hypercholesterolaemic subjects

Cited by 23 publications

References 37 publications

The Beneficial Effects of Alpha Lipoic Acid Supplementation on Lp-PLA2 Mass and Its Distribution between HDL and apoB-Containing Lipoproteins in Type 2 Diabetic Patients: A Randomized, Double-Blind, Placebo-Controlled Trial

The Beneficial Effects of Alpha Lipoic Acid Supplementation on Lp-PLA2 Mass and Its Distribution between HDL and apoB-Containing Lipoproteins in Type 2 Diabetic Patients: A Randomized, Double-Blind, Placebo-Controlled Trial

Weighting approaches for a genetic risk score and an oxidative stress score for predicting the incidence of obesity

Effects of overweight and the PLA2G7 V279F polymorphism on the association of age with systolic blood pressure

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