“…For this purpose, the eVects of NAN-190 on methamphetamine-induced locomotor, anorectic, hyperthermic, and antinociceptive activities were investigated. The latter activity of methamphetamine is not well established as the former three activities, however, the amphetamines and many other sympathomimetics have long been known to produce analgesia (Ginawi et al, 1980;Leimdorfer and Metzner, 1949;Major and Pleuvry, 1971). Moreover sympathetic stimulation at times of excitement, anger or exercise can cause physiological analgesia in human.…”