Effects of α-methylnoradrenaline on cardiac metabolism

Satchell, D.G.; Freeman, Shirley E.; Hopkins, Sondra V.

doi:10.1016/0006-2952(71)90298-x

Cited by 3 publications

(1 citation statement)

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“…The increase in blood pressure and heart rate observed after a-blockade might be caused by an effect on p-adrenoceptors since a-methylnoradrenaline possesses fl-agonistic activity and intraventricular injection of p-mimetics such as isoprenaline sometimes causes pressor responses and tachycardia (Toda, Matsuda & Shimamoto, 1969;Satchell, Freeman & Hopkins, 1971;Bhargava, Mishra & Tangri, 1972;Day & Roach, 1974).…”

Section: Discussionmentioning

confidence: 99%

Centrally Induced Hypotension and Bradycardia After Administration of Α‐methylnoradrenaline Into the Area of the Nucleus Tractus Solitarii of the Rat

Jong

Nijkamp

1976

British J Pharmacology

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1 In anaesthetized rats, bilateral injections of alpha-methylnoradrenaline, noradrenaline or adrenaline into the area of the nucleus tractus solitarii (NTS) of the brain stem caused dose-dependent decreases of systemic arterial blood pressure and heart rate. The effects of alpha-methylnoradrenaline were most pronounced and lasted longest. 2 The cardiovascular effects of alpha-methylnoradrenaline appeared to be restricted to the medio-caudal part of the NTS. 3 Prior administration of the alpha-adrenoceptor blocking agent, phentolamine, reversed the fall in blood pressure and heart rate induced by alpha-methylnoradrenaline into an increase. 4 Systemic administration of atropine combined with vagotomy potentiated the inhibitory effects of alpha-methylnoradrenaline on the cardiovascular system.

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Section: Discussionmentioning

confidence: 99%