Effects of α,β-unsaturated lactones on larval survival and gut trypsin as well as oviposition response of Aedes aegypti

Abstract

Lactones are organic cyclic esters that have been described as larvicides against Aedes aegypti and as components of oviposition pheromone of Culex quinquefasciatus. This work describes the effect of six α,β-unsaturated lactones (5a-5f) on survival of A. aegypti fourth instar larvae (L4). It is also reported the effects of the lactones on L4 gut trypsin activity and oviposition behavior of A. aegypti females. Five lactones were able to kill L4 being the lactones 5a (LC50 of 39.05 ppm), 5e (LC50 of 36.30 ppm) and 5f (LC50 of 40.46 ppm) the most promising larvicides. Only the lactone 5a inhibited L4 gut trypsin activity, with an IC50 of 115.15 µg/mL. Lactones 5a, 5c, 5d and 5e did not exert deterrent or stimulatory effects on oviposition, whereas lactone 5b exhibited a strong deterrent oviposition activity. In conclusion, this work introduces new α,β-unsaturated lactones as promising alternatives to control A. aegypti dissemination. The larvicidal mechanism of the lactone 5a can involve the disruption of proteolysis at larval gut.

Derivatization increases mosquito larvicidal activity of the sesquiterpene lactone parthenin isolated from the invasive weed Parthenium hysterophorus

“…aegypti has been demonstrated previously. 30 Our results are consistent with this finding. Mosquito larvicidal activity of similar derivatives prepared from the structural modification in the double bond attached to ring C in 1 , will confirm this suggestion.…”

“…Interestingly, compounds with similar functional groups have previously displayed larvicidal activity against Ae. aegypti 30 . In this study, we tested the hypothesis that the mosquito larvicidal activity of 1 , the key metabolite of Parthenium hysterophorus , is mediated by the α,β‐unsaturated carbonyl group, and that modification of this moiety can improve its bioactivity against An.…”

An Efficient K2CO3-Promoted Synthesis of 1-Bromo-2-aryloxyethane Derivatives and Evaluation of Larval Mortality against Aedes aegypti

“…In this context, the synthesis of organic compounds including aromatic rings in their structure has been widely reported in the literature. The compounds with aromatic substructure have been reported to show a broad spectrum of pharmaceutical, agricultural, and chemical engineering applications and are scaffolding reagents for synthetic organic chemistry [1][2][3][4][5][6]. They are also ubiquitous structural units in biologically important molecules such as cyclooxygenase and -galactosidase inhibitors and anticancer porphyrins [7].…”