Effects of α1-adrenoceptor antagonists on phenylephrine-induced salivary secretion and intraurethral pressure elevation in anesthetized rats

Yanai-Inamura, Hiroko; Ohtake, Akiyoshi; Noguchi, Yukiko; Hatanaka, Toshiki; Suzuki, Michitaka; Ueshima, Koji; Sato, Shuichi; Sasamata, Masao

doi:10.1016/j.ejphar.2012.01.019

Cited by 5 publications

(6 citation statements)

References 30 publications

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“…TAM presumably alters the epididymal epithelial secretory and absorptive functions, or epididymal contraction, ultimately impairing spermatozoa viability as proposed by Kimsakulvech et al (3). This effect was also dosedependent, similar to previous reports investigating the salivary gland function (15). Alterations in seminal ALP concentration may indicate epididymal blockage (20), but the concentrations used herein did not differ between groups.…”

Section: Discussionsupporting

confidence: 89%

“…Semen quality following complete ejaculations between 3 and 24 h after injection of normal saline (CON), tamsulosin 134.8 nM/kg (LTAM), and tamsulosin 269.7 nM/kg (HTAM) (mean ± SEM). intraurethral pressure in dogs (12) and salivary inhibition in rats (15) were both reported to occur in a dose-dependent manner with alpha-1 adrenoceptor antagonist. The dosedependent effect of TAM on ejaculation demonstrated herein may indicate the involvement of the central nervous system.…”

Section: Discussionmentioning

confidence: 99%

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Dose-dependent effects of tamsulosin on the ejaculation and semen quality in bucks

Kimsakulvech¹,

Suttiyotin²,

Pinyopummin³

2015

Turk J Vet Anim Sci

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The objective of this study was to investigate the effect of tamsulosin (TAM) dosages on ejaculation and semen quality. Two sets of Latin square experiment design were applied to 6 bucks receiving normal saline (CON), TAM 134.8 nM/kg (LTAM), or 269.7 (HTAM) nM/kg at 1-week intervals. Semen collection, libido, and ejaculatory scoring were undertaken at 3, 6, 9, 12, and 24 h after injection. Heart rate and body temperature were measured before administration and at 30 min, and before semen collection. The results showed that libido score and heart rate were not affected by treatments. Ejaculatory suppression was observed in both TAM groups. The percentage of ejaculatory suppression was 91.7% by 3 h for both TAM dosages and gradually diminished. Ejaculatory recovery in all bucks was observed by 12 h. Ejaculatory suppression remained unchanged between LTAM and HTAM, but HTAM caused more anejaculation by 6 h (P < 0.05). Some semen parameters of both TAM groups were significantly different from the CON group from 6 to 12 h; however, the values returned to being similar by 24 h. Both TAM dosages had temporary effects on ejaculatory suppression and semen quality, and the effective period was dose-dependent.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Dose-dependent effects of tamsulosin on the ejaculation and semen quality in bucks

Kimsakulvech¹,

Suttiyotin²,

Pinyopummin³

2015

Turk J Vet Anim Sci

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“…Some studies describe a high incidence of dry mouth as a side effect of treatment with α 1 -AR antagonists [ 24 ]. Therefore, to identify the specific α 1 -AR subtype accountable for the phenylephrine-induced trafficking of AQP5, rat parotid tissue slices were incubated with specific α 1 -AR antagonists.…”

Section: Resultsmentioning

confidence: 99%

“…However, antagonists have many kinds of effects [ 49 ]. Antagonists of the α 1A -AR inhibit phenylephrine-induced salivary secretion, resulting in xerostomia or dry mouth [ 24 ]. In the present study, we showed the inhibitory mechanism in relation to loss of AQP5 trafficking.…”

Section: Discussionmentioning

confidence: 99%

“…α 1 -AR antagonists are widely used in the treatment of lower urinary tract symptoms (LUTS) [ 18 , 19 , 20 , 21 , 22 ] and cardiovascular diseases [ 23 ]. However, α 1 -AR antagonists cause dry mouth as a side effect [ 24 ]. The α 1A -AR is linked to G-protein G q/11 signaling and a subsequent rise in [Ca 2+ ]i, while the α 1B -AR activates the mitogen-activated kinase (MAPK)/extracellular signal-regulated kinase 1 and 2 (ERK1/2) [ 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

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Mechanisms Underlying Activation of α1-Adrenergic Receptor-Induced Trafficking of AQP5 in Rat Parotid Acinar Cells under Isotonic or Hypotonic Conditions

Bragiel

Wang

Pieczonka

et al. 2016

IJMS

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Defective cellular trafficking of aquaporin-5 (AQP5) to the apical plasma membrane (APM) in salivary glands is associated with the loss of salivary fluid secretion. To examine mechanisms of α1-adrenoceptor (AR)-induced trafficking of AQP5, immunoconfocal microscopy and Western blot analysis were used to analyze AQP5 localization in parotid tissues stimulated with phenylephrine under different osmolality. Phenylephrine-induced trafficking of AQP5 to the APM and lateral plasma membrane (LPM) was mediated via the α1A-AR subtype, but not the α1B- and α1D-AR subtypes. Phenylephrine-induced trafficking of AQP5 was inhibited by ODQ and KT5823, inhibitors of nitric oxide (NO)-stimulated guanylcyclase (GC) and protein kinase (PK) G, respectively, indicating the involvement of the NO/ soluble (c) GC/PKG signaling pathway. Under isotonic conditions, phenylephrine-induced trafficking was inhibited by La3+, implying the participation of store-operated Ca2+ channel. Under hypotonic conditions, phenylephrine-induced trafficking of AQP5 to the APM was higher than that under isotonic conditions. Under non-stimulated conditions, hypotonicity-induced trafficking of AQP5 to the APM was inhibited by ruthenium red and La3+, suggesting the involvement of extracellular Ca2+ entry. Thus, α1A-AR activation induced the trafficking of AQP5 to the APM and LPM via the Ca2+/ cyclic guanosine monophosphate (cGMP)/PKG signaling pathway, which is associated with store-operated Ca2+ entry.

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Validating a model for medication‐related dental outcomes in older people

et al. 2021

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Effects of α1-adrenoceptor antagonists on phenylephrine-induced salivary secretion and intraurethral pressure elevation in anesthetized rats

Cited by 5 publications

References 30 publications

Dose-dependent effects of tamsulosin on the ejaculation and semen quality in bucks

Dose-dependent effects of tamsulosin on the ejaculation and semen quality in bucks

Mechanisms Underlying Activation of α1-Adrenergic Receptor-Induced Trafficking of AQP5 in Rat Parotid Acinar Cells under Isotonic or Hypotonic Conditions

Validating a model for medication‐related dental outcomes in older people

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