Effects of β-glucan on some environmental toxins: An overview

Větvička, Václav

doi:10.5507/bp.2013.090

Cited by 6 publications

(6 citation statements)

References 39 publications

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“…Moreover, it is also known that the cell wall of yeast is composed of complex polymers β- d -glucans, α-mannans, α-mannoprotein and a minor amount of chitin, all of which have a number of bioprotective properties [ 29 ]. In the specific case of glucan, this polysaccharide has caught scientific attention, mainly due to its immunomodulatory capacity, which has been demonstrated in some studies to decrease the immunosuppressive actions of various immunotoxins, including mercury and perluoroctanic acid [ 30 ]. Similarly, field studies related to his genotoxicity, antigenotoxicity and chemoprevention capacity have increased.…”

Section: Discussionmentioning

confidence: 99%

Prevention of Aflatoxin B1-Induced DNA Breaks by β-D-Glucan

Madrigal-Bujaidar¹,

Morales-González²,

Sánchez-Gutiérrez

et al. 2015

Toxins

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Aflatoxins are a group of naturally-occurring carcinogens that are known to contaminate different human and animal foodstuffs. Aflatoxin B1 (AFB1) is the most genotoxic hepatocarcinogenic compound of all of the aflatoxins. In this report, we explore the capacity of β-d-glucan (Glu) to reduce the DNA damage induced by AFB1 in mouse hepatocytes. For this purpose, we applied the comet assay to groups of animals that were first administered Glu in three doses (100, 400 and 700 mg/kg bw, respectively) and, 20 min later, 1.0 mg/kg of AFB1. Liver cells were obtained at 4, 10 and 16 h after the chemical administration and examined. The results showed no protection of the damage induced by AFB1 with the low dose of the polysaccharide, but they did reveal antigenotoxic activity exerted by the two high doses. In addition, we induced a co-crystallization between both compounds, determined their fusion points and analyzed the molecules by UV spectroscopy. The data suggested the formation of a supramolecular complex between AFB1 and β-d-glucan.

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Section: Discussionmentioning

confidence: 99%

Prevention of Aflatoxin B1-Induced DNA Breaks by β-D-Glucan

Madrigal-Bujaidar¹,

Morales-González²,

Sánchez-Gutiérrez

et al. 2015

Toxins

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“…Similarly, Jayasekara et al [62] and Anusuya and Sathiyabama [140] reported the antifungal efficacy of β-D glucan against the Saccharomyces cerevisiae strain and in the prevention of rhizome rot disease of turmeric, respectively. Vetvicka [141] examined the impact of β-glucan against environmental toxins like mycotoxin, aflatoxin, and depleted uranium.…”

Section: Microbial β-Glucanmentioning

confidence: 99%

Microbial Biopolymers: From Production to Environmental Applications—A Review

Sharma,

Tellili,

Kacem

et al. 2024

Applied Sciences

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Industrial evolution and agricultural expansion, explained by continuing population growth, have rendered enormous problems for the world throughout the past few decades, primarily because of waste generation. To reduce environmental impact and dependence on fossil fuels, scientists have explored replacing synthetic polymers with environmentally friendly and sustainable alternatives in many emergent applications. In this regard, microbial biopolymers have gained special attention. Many biopolymers originating from various strains of bacteria, fungi, and algae have been reported and their possible applications have increased rapidly. This review focuses on the wide range of microbial biopolymers, their characteristics, and factors influencing their production. The present study also describes the environmental applications of microbial biopolymers. The use of these biopolymers is very attractive as a value-added and sustainable approach to wastewater treatment. By acting as adsorbents, coagulants, and flocculants as well as filters in membrane processes, microbial biopolymers shine as promising solutions beyond conventional methods. They can be integrated into various stages of the treatment process, further enhancing the efficiency of wastewater treatment methods. Microbial biopolymer applications in bioremediation and soil stabilization are also reviewed. Several studies have demonstrated the strong potential of biopolymers in soil improvement due to their ability to minimize permeability, eliminate heavy metals, stabilize soil, and limit erosion. Challenges related to scaling up and the downstream processing of microbial biopolymers, as well as its future perspectives in environmental applications, are also discussed.

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“…Meanwhile Narusaka et al [12] stated that yeast cell walls extracted from S. pastorianus containing ±40% mannoprotein, 60% β-glucan, and 1.3% chitin could inhibit the growth of the fungus Colletotrichum higginsianum by activating resistance to fungi through the Salicylic Acid (SA)-dependent pathway. β-glucan has been found to have a role in decontaminating toxin that remain in the environment including in water, with the advantages that the toxicity is biologically reduced, saving mammalian cells [21,22]. Meanwhile, β-glucan and its cationic derivatives show decontamination effects by means of their polycation structure, which easily react with the fungi's biological membrane, and show antifungal activities [22].…”

Section: Introductionmentioning

confidence: 99%

“…Glucans can not only play a role in mycotoxin absorption but can also directly reduce aflatoxin production. (1,3)-β-D-glucan with side chain (1,6)-β-D-glucan can regulate the presence of aflatoxin [21].…”

Section: Introductionmentioning

confidence: 99%

Antifungal and Aflatoxin-Reducing Activity of β-Glucan Isolated from Pichia norvegensis Grown on Tofu Wastewater

Utama

Suraloka

Rialita

et al. 2021

Foods

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Yeast can be isolated from tofu wastewater and the cell wall in the form of β-glucan can act as a natural decontaminant agent. This study aimed to isolate and characterize native yeast from tofu wastewater, which can be extracted to obtain β-glucan and then identify the yeast and its β-glucan activity regarding antifungal ability against Aspergillus flavus and aflatoxin-reducing activity towards aflatoxin B1 (AFB1) and B2 (AFB2). Tofu wastewater native yeast was molecularly identified, and the growth observed based on optical density for 96 h and the pH also measured. β-glucan was extracted from native yeast cell walls with the acid-base method and then the inhibition activity towards A. flavus was tested using the well diffusion method and microscopic observation. AFB1 and AFB2 reduction were identified using HPLC LC-MS/MS. The results showed that the native yeast isolated was Pichia norvegensis with a β-glucan yield of 6.59%. Pichia norvegensis and its β-glucan showed an inhibition zone against Aspergillus flavus of 11.33 ± 4.93 and 7.33 ± 3.51 mm, respectively. Total aflatoxin-reducing activity was also shown by Pichia norvegensis of 26.85 ± 2.87%, and β-glucan of 27.30 ± 1.49%, while AFB1- and AFB2-reducing activity by Pichia norvegensis was 36.97 ± 3.07% and 27.13 ± 1.69%, and β-glucan was 27.13 ± 1.69% and 32.59 ± 4.20%, respectively.

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Effects of β-glucan on some environmental toxins: An overview

Cited by 6 publications

References 39 publications

Prevention of Aflatoxin B1-Induced DNA Breaks by β-D-Glucan

Prevention of Aflatoxin B1-Induced DNA Breaks by β-D-Glucan

Microbial Biopolymers: From Production to Environmental Applications—A Review

Antifungal and Aflatoxin-Reducing Activity of β-Glucan Isolated from Pichia norvegensis Grown on Tofu Wastewater

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