Effects of β-hydroxy-β-methylbutyrate on muscle damage after a prolonged run

Knitter, A. E.; Panton, Lynn B.; Rathmacher, John A.; Petersen, Aaron C.; Sharp, Rick L.

doi:10.1152/jappl.2000.89.4.1340

Cited by 140 publications

(113 citation statements)

References 25 publications

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“…Physical activity alters the enzyme's activity in athletes and the Lactate dehydrogenase is one among the enzyme that present in blood and it is used to monitor the training status of athletes [15,16,21,25]. LDH enzyme level is increased during muscular damage/non-functional overreaching state which can lead to a reduced physical performance [14,19]. The molecular level changes that increase LDH level is the myofibrillar damage in particular sarcomeric Z-disk disruption [13].…”

Section: Discussionmentioning

confidence: 99%

Reference Interval for Enzyme Lactate Dehydrogenase in Male and Female Athletes

2017

IJSR

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Section: Discussionmentioning

confidence: 99%

Reference Interval for Enzyme Lactate Dehydrogenase in Male and Female Athletes

2017

IJSR

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“…Regarding the type of exercised used in the study design, fourteen used RT, three studies performed both aerobic and RT (PORTAL, ZADIK, RABINOWITZ et al, 2011;O'CONNOR and CROWE, 2003;VUKOVICH, STUBBS, BOHLKEN, 2001) and two studies used the aerobic training (downhill) (NUNAN, HOWATSON and VAN SOMEREN, 2010;KNITTER, PANTON, RATHMACHER et al, 2000). There were three studies using aerobic training plus HMβ supplementation (presented in this review): two studies suggested that HMβ supplementation might prevent muscle damage in strenuous aerobic exercise (KNITTER, PANTON, RATHMACHER et al, 2000) and improve lean mass and strength gains (PORTAL, ZADIK, RABINOWITZ et al, 2011), however, these effects does not seem to occur in elite athletes (O'CONNOR and CROWE, 2003).…”

Section: Exercise Type and Effects On Skeletal Musclementioning

confidence: 99%

β-hydroxy-β-methylbutyrate (HMβ), Physical training and skeletal muscle: a systematic review

et al. 2017

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Skeletal muscle mass gain is beneficial in several situations. It improves athlete's performance and quality of life in pathological situations. The existence of different methods that are able to increase muscle mass brings up discussions about nutritional supplements use on physically active individuals. β-hydroxy-β-methylbutyrate is a Leucine metabolite and it's believed to have an anticatabolic effect with different results depending on the type of exercise done. Objective: The objective of this research was to identify and categorize the methodological features and results of β-hydroxy-β-methylbutyrate (HMβ) studies, physical exercise and its effects on skeletal muscle in the last 20 years. Materials and Methods: We carried out a review in the literature using PUBMED and Medline data bases. We analyzed 19 articles from the 4587 initially found, according to the inclusion and exclusion criteria. After the selection we analyzed the date of publishing and country of origin, sample size and type, dosage used, exercise protocol and results on skeletal muscle. Results: Most of the studies came from the USA, were published between the years of 2000 and 2005. Most of the papers used only males and the main dosage used was 3.0g/day with resistance exercise, although endurance exercise and untrained individuals showed some interesting results. Data from these studies varied from increase in muscle mass and muscle strength, recovery of isokinetic and isometric muscle function, decrease in lactate dehydrogenase and proteolysis and decrease in creatine kinase. Conclusion We can conclude that although HMβ has some positive effects on untrained individuals, its effects on trained individuals still need further confirmation.

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“…Panton et al 17 e Knitter et al 18 reportaram redução nas concentrações plasmáticas de creatina cinase (CK) e lactato desidrogenase (LDH), que são indicadores de danos na membrana muscular, assim como diminuição da excreção urinária de 3-methil-histidina (3-MH) durante o treinamento, o que indica menores taxas de proteólise.…”

Section: Efeitos Do Hmb Em Indivíduos Iniciando O Programa De Treinamunclassified

Efeitos da suplementação de b-hidroxi-b-metilbutirato sobre a força e a hipertrofia

Álvares

Meirelles

2008

Rev. Nutr.

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Efeitos da suplementação de β-hidroxi-β-metilbutirato sobre a força e a hipertrofia Effects of β-hydroxy-β-methylbutyrate supplementation on strength and hypertrophyThiago da Silveira ALVARES 1 Cláudia de Mello MEIRELLES 1,2,3 R E S U M OO β-hidroxi-β-metilbutirato é um metabólito da leucina estudado devido aos seus efeitos anticatabólicos e possíveis implicações sobre os ganhos de força e massa muscular associados ao treinamento contra--resistência (conhecido como musculação). O objetivo deste trabalho foi revisar a literatura referente à suplementação de β-hidroxi-β-metilbutirato e os seus efeitos sobre força e hipertrofia em adultos jovens e idosos iniciantes ou treinados em treinamento contra-resistência. Estudos em indivíduos iniciando um programa de treinamento contra-resistência sugerem que a suplementação diária de 1,5 a 3,0g de β-hidroxi-β-metilbutirato pode trazer benefício ergogênico durante as primeiras quatro ou cinco semanas. Entretanto, à medida que o programa de treinamento evolui, tais efeitos não permanecem e os ganhos de força e massa muscular são proporcionados apenas pelo treinamento contra-resistência. Em indivíduos treinados, os resultados parecem não ser os mesmos, uma vez que, desde o início da suplementação, o β-hidroxi-β-metilbutirato não demonstra qualquer benefício adicional aos induzidos pelo treinamento contra-resistência. Alguns efeitos do β-hidroxi-β-metilbutirato na redução do colesterol total e lipoproteína de baixa densidade também foram observados, porém, devido às poucas evidências, não há recomendações para tal finalidade. Nenhum efeito adverso da suplementação foi observado, sendo, aparentemente, segura, contudo a maioria dos estudos foi realizada em curto prazo (menos de 4 semanas) e em indivíduos destreinados. Assim, mais estudos são necessários para esclarecer o mecanismo fisiológico por meio do qual o β-hidroxi-β-metilbutirato exerce seus efeitos anticatabólicos em destreinados e para observar possíveis efeitos adversos.

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Effects of β-hydroxy-β-methylbutyrate on muscle damage after a prolonged run

Cited by 140 publications

References 25 publications

Reference Interval for Enzyme Lactate Dehydrogenase in Male and Female Athletes

Reference Interval for Enzyme Lactate Dehydrogenase in Male and Female Athletes

β-hydroxy-β-methylbutyrate (HMβ), Physical training and skeletal muscle: a systematic review

Efeitos da suplementação de b-hidroxi-b-metilbutirato sobre a força e a hipertrofia

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