Effects of μ-Opioid Receptor Agonist DAMGO on Heart Contractility and Necrotic Injury to Cardiomyocytes during Ischemia and Reperfusion of Isolated Rat Heart

Ласукова, Т. В.; Maslov, L. N.; Gorbunov, A. S.

doi:10.1007/s10517-015-3058-7

Cited by 6 publications

(6 citation statements)

References 11 publications

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“…Activation of µ and δ OR is also involved in the infarct sparing effect of postconditioning in vivo (Zatta et al 2008). Last but not least, we found that the δ 1 OR, but not µ and κ OR, are involved in cardioprotective effect of postconditioning in vitro (Lasukova et al 2014(Lasukova et al , 2016.…”

Section: Discussionmentioning

confidence: 75%

“…It is well known that activation of OR results in cardioprotection against acute ischemia/reperfusion injury , Heusch 2015, Headrick et al 2015, Fraessdorf et al 2015, Xu et al 2015. Regarding the role of OR subtypes, it has been found that δ OR agonists have protective effect in the isolated rat heart (Karck et al 2001, Maslov et al 2006, Lasukova et al 2014. Moreover, opioid TAN-67 increased cardiac tolerance to ischemia and reperfusion via δ 1 OR occupancy (Huh et al 2001).…”

Section: Discussionmentioning

confidence: 98%

“…Moreover, opioid TAN-67 increased cardiac tolerance to ischemia and reperfusion via δ 1 OR occupancy (Huh et al 2001). We have studied the effects of μ OR activation on the rat heart tolerance to ischemia and reperfusion (Lasukova et al 2015). Stimulation of μ OR in vivo by intraperitoneal administration of selective agonist DAMGO (0.1 mg/kg) reduced creatine kinase release from the isolated heart during reperfusion following global ischemia.…”

Section: Discussionmentioning

confidence: 99%

“…(Lasukova et al 2014, Alexander et al 2017, the selective δ OR antagonist TIPP(ψ) (30 nM)(Martin et al 2001), the selective δ 1 OR antagonist BNTX (1 nM) (Zeng et al 2011), the selective δ 2 OR antagonist naltriben (1 nM)(Zhu et al 2009), the selective μ OR antagonist CTAP (100 nM)(Devidze et al 2008), or the selective κ-OR antagonist nor-binaltorphimine (3 nM) (Stevens…”

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confidence: 99%

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Participation of opioid receptors in the cytoprotective effect of chronic normobaric hypoxia

Naryzhnaya

Khaliulin²,

Lishmanov³

et al. 2019

Physiol Res

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We studied the role of the delta, micro, and kappa opioid receptor (OR) subtypes in the cardioprotective effect of chronic continuous normobaric hypoxia (CNH) in the model of acuteanoxia-reoxygenation of isolated cardiomyocytes. Adaptation of rats to CNH was performed by their exposure to atmosphere containing 12% of O(2) for 21 days. Anoxia-reoxygenation of cardiomyocytes isolated from normoxiccontrol rats caused the death of 51 % of cells and lactate dehydrogenase (LDH) release. Adaptation of rats to CNH resulted in the anoxia/reoxygenation-induced cardiomyocyte death of only 38 %, and reduced the LDH release by 25 %. Pre-incubation of the cells with either the non-selective OR (opioid receptor) blocker naloxone (300 nM/l), the delta OR antagonist TIPP(psi) (30 nM/l), the selective delta(2) OR antagonist naltriben (1 nM/l) or the micro OR antagonist CTAP (100 nM/l) for 25 minutes before anoxia abolished the reduction of cell death and LDH release afforded by CNH. The antagonist of delta(1) OR BNTX (1 nM/l) or the kappa OR antagonist nor-binaltorphimine (3 nM/l) did not influence the cytoprotective effects of CNH. Taken together, the cytoprotective effect of CNH is associated with the activation of the delta(2) and micro OR localized on cardiomyocytes.

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Participation of opioid receptors in the cytoprotective effect of chronic normobaric hypoxia

Naryzhnaya

Khaliulin²,

Lishmanov³

et al. 2019

Physiol Res

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“…Both ischemic preconditioning (IPC) and remote ischemic preconditioning (RIPC) had been identified to improve the outcome of organs suffering from IRI [ 7 , 8 ]. Opioid receptors even an extrahepatic opioid receptor-associated mechanism may participate in this protection [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Remifentanil Preconditioning Attenuates Hepatic Ischemia-Reperfusion Injury in Rats via Neuronal Activation in Dorsal Vagal Complex

Cui

Fang

Yin

et al. 2018

Mediators of Inflammation

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Remifentanil, an ultra-short acting opiate, has been reported to protect against hepatic ischemia-reperfusion injury, which is a major cause of postoperative liver dysfunction. The objective of this study was to determine whether a central vagal pathway is involved in this protective procedure. Rat models of hepatic ischemia-reperfusion were used in the experimental procedures. The results revealed that intravenous pretreatment with remifentanil decreased serum aminotransferases and hepatic histologic damage; however, an intraperitoneal injection of μ-opioid receptor antagonist did not abolish the protection of remifentanil preconditioning. c-Fos immunofluorescence of the brain stem showed that dorsal motor nucleus of the vagus was activated after remifentanil preconditioning. Moreover, serum alanine aminotransferase, histopathologic damage, and apoptosis decreased in remifentanil preconditioning group compared to vagotomized animals with remifentanil preconditioning, and there was no statistical difference of TNF-α and IL-6 between NS/Va and RPC/Va groups. In addition, remifentanil microinjection into dorsal vagal complex decreased serum aminotransferases, inflammatory cytokines, and hepatic histologic injury and apoptosis, and these effects were also abolished by a peripheral hepatic vagotomy. In conclusion, remifentanil preconditioning conferred liver protection against ischemia-reperfusion injury, which was mediated by the central vagal pathway.

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Endogenous Opiates and Behavior: 2015

Bodnar

2017

Peptides

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Effects of μ-Opioid Receptor Agonist DAMGO on Heart Contractility and Necrotic Injury to Cardiomyocytes during Ischemia and Reperfusion of Isolated Rat Heart

Cited by 6 publications

References 11 publications

Participation of opioid receptors in the cytoprotective effect of chronic normobaric hypoxia

Participation of opioid receptors in the cytoprotective effect of chronic normobaric hypoxia

Remifentanil Preconditioning Attenuates Hepatic Ischemia-Reperfusion Injury in Rats via Neuronal Activation in Dorsal Vagal Complex

Endogenous Opiates and Behavior: 2015

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