Effects ofAloe vera ingestion in the rat. I. Growth, food and fluid intake and serum chemistry

Herlihy, Jeremiah T.; Bertrand, Helen A.; Kim, J. D.; Ikeno, Yuji; Yu, B. P.

doi:10.1002/(sici)1099-1573(199805)12:3<183::aid-ptr219>3.0.co;2-q

Cited by 18 publications

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“…Another study examining the effects of long-term A. vera intake on the growth of Fischer 344 male rats showed that ingestion of A. vera by rats led to an increase in body weight [24]. They also suggested that A. vera intake did not cause any significant adverse effects in rats.…”

Section: Discussionmentioning

confidence: 99%

Aloe vera Gel Extract Prolongs Lifespan in Caenorhabditis elegans

Berk

2024

Cumhuriyet Science Journal

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Caenorhabditis elegans (C. elegans), with its superiority and physiological aging properties, has become a widely recognized model system in research on aging, longevity mechanisms, age-related diseases, and drug screening. Lifespan-extending mutations in C. elegans are known to slow the aging process by interfering with a number of signaling pathways such as the AMP-activated protein kinase (AMPK), mechanistic target of rapamycin (mTOR) and insulin/IGF-1 signaling (IIS) pathways. We aimed to see how Aloe vera (A. vera) gel affects the fertilization and lifespan of C. elegans. In the presence of all A. vera gel concentrations (0.312 - 5 mg/mL), the fertilization capacity of N2 worms increased and extended their lifespan as well as increased their body size. We found that in N2 worms cultured with 2.5 mg/ml A. vera gel, sgk-1, age-1, and let-363 mRNA expression was significantly increased, while rsks-1 mRNA expression was significantly decreased. We therefore conclude that it may extend lifespan through a mechanism specifically dependent on mTOR signaling. All these observations will provide a new perspective on mammalian life extension through the model organism C. elegans.

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Section: Discussionmentioning

confidence: 99%

Aloe vera Gel Extract Prolongs Lifespan in Caenorhabditis elegans

Berk

2024

Cumhuriyet Science Journal

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Initial characterization of the effects of Aloe vera at a crayfish neuromuscular junction

Friedman

1999

Phytother. Res.

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This study examines the effects of Aloe vera on neurotransmission processes in a well‐established invertebrate neuromuscular junction preparation. We studied concentration‐response relationships of an Aloe vera extract on excitatory junctional potentials (EJPs) at the opener muscle of the dactyl in the first and second walking limbs of crayfish (Procambarus clarkii and simulans). We observed concentration‐dependent depolarizations of the muscle fibre membrane resting potential, depression of EJP amplitudes and an increase in latency to onset of the EJP following electrical stimulation of the isolated excitatory axon in the meropodite. These effects occurred with Aloe concentrations within the 1%–10% (wt‐vol) range. Effects of lower concentrations, ranging to a minimum of 0.01% were equivocal. The effects of Aloe were at least partially, and in a majority of cases totally, reversible. EJPs reduced by Aloe could be restored by increasing the nerve stimulation amplitude. This, along with the latency increase, suggests a depression of action potential generation and conduction. The results provide a preliminary characterization of the effects of Aloe vera on the neurotransmission process and suggest that these effects may at least partially account for Aloe's analgesic and antiinflammatory effects. This study shows that the crayfish NMJ preparation should be useful for further elucidating the location(s) and mechanism(s) of action of Aloe on the nervous system. Copyright © 1999 John Wiley & Sons, Ltd.

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The influence of long‐term Aloe vera ingestion on age‐related disease in male Fischer 344 rats

Ikeno

Hubbard

Lee

et al. 2002

Phytotherapy Research

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The effects of long-term Aloe vera ingestion on age-related diseases were investigated using male specific pathogen-free (SPF) Fischer 344 rats. Experimental animals were divided into four groups: Group A, the control rats fed a semi-synthetic diet without Aloe vera; Group B, rats fed a diet containing 1% freeze-dried Aloe vera filet; Group C, rats fed a diet containing 1% charcoal-processed, freeze-dried Aloe vera filet; and Group D, rats fed the control diet and given whole leaf charcoal-processed Aloe vera (0.02%) in the drinking water. This study demonstrates that life-long Aloe vera ingestion produced neither harmful effects nor deleterious changes. In addition, Aloe vera ingestion appeared to be associated with some beneficial effects on age-related diseases. Groups B exhibited significantly less occurrence of multiple causes of death, and a slightly lower incidence of fatal chronic nephropathy compared with Group A rats. Groups B and C rats showed the trend, slightly lower incidences of thrombosis in the cardiac atrium than Group A rats. Therefore, these findings suggest that life-long Aloe vera ingestion does not cause any obvious harmful and deleterious side effects, and could also be beneficial for the prevention of age-related pathology.

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Effects ofAloe vera ingestion in the rat. I. Growth, food and fluid intake and serum chemistry

Cited by 18 publications

References 0 publications

Aloe vera Gel Extract Prolongs Lifespan in Caenorhabditis elegans

Aloe vera Gel Extract Prolongs Lifespan in Caenorhabditis elegans

Initial characterization of the effects of Aloe vera at a crayfish neuromuscular junction

The influence of long‐term Aloe vera ingestion on age‐related disease in male Fischer 344 rats

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