Effects on Alimentary High-Fat Diet on Thiol Disulfide Homeostasis in Rats

Karaman, Yu. K.; Новгородцева, Т. П.; Yankova, Vera

doi:10.1007/s10517-013-2244-8

Cited by 5 publications

(6 citation statements)

References 6 publications

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“…The lipid storage function of the liver and the preference of red muscle to use fatty acids as fuel explain these tissue-dependent increases [ 31 , 32 ]. These results agree with those of studies showing that a higher lipid content in feed increases both lipid and protein peroxidation markers from 10 to 90% [ 4 , 6 , 11 ]. Interestingly, the reduced AOPP levels in the HP groups could be correlated with the lower nitrogen fractionation (Δδ 15 N) found in the white muscle of the same fish analyzed in this work [ 18 ].…”

Section: Discussionsupporting

confidence: 92%

“…However, the opposite results were shown by Lasker et al (2019) [11], who observed that a high-fat diet reduced the activities of SOD and CAT. This is in line with the results observed in murine models by Karaman et al (2013) [6] for reduced thiols and by Jarukamjorn et al (2016) [57] for relative expression and enzyme activity, with an initial upregulation of protective mechanisms that is exceeded and depressed after a while.…”

Section: Effect Of Diet On Oxidative Stress Statussupporting

confidence: 91%

“…Increasing the levels of dietary energy proceeding from lipids is associated with a higher fat deposition, particularly in the liver, adipose tissue and muscle. It is well established that raising the dietary lipid content leads to the production of reactive oxygen species (ROS) through diverse pathways, generating downstream molecules such as malondialdehyde (MDA), advanced oxidation protein products (AOPP) and oxidized thiols, which can be used as biochemical markers of the tissue redox status in fish [ 6 , 7 ]. Marine fish feed is rich in polyunsaturated fatty acids (PUFAs), which accumulate in tissues and provide a healthy meal for human consumption.…”

Section: Introductionmentioning

confidence: 99%

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Interaction between the Effects of Sustained Swimming Activity and Dietary Macronutrient Proportions on the Redox Status of Gilthead Sea Bream Juveniles (Sparus aurata L.)

et al. 2022

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The combination of physical exercise and a balanced diet presents substantial health benefits and could improve fish production. However, the redox balance can be affected by training regimen, dietary macronutrient ratio and their interaction. In this study, we conjointly evaluated the effects of physical activity (by voluntary swimming (VS) or sustained swimming as exercise (Ex)) and diet composition (by high-protein (HP) or high-lipid (HE) commercial diets) after 6 weeks on oxidative stress status in liver, white muscle and red muscle of gilthead sea bream juveniles. The HE diet increased the biochemical redox markers’ thiobarbituric acid reactive substances (TBARS), advanced oxidation protein products (AOPP) and reduced thiols (-SH) in the different tissues. Exercise increased AOPP and –SH levels in liver but reduced TBARS levels in white muscle. Regarding the expression of oxidative stress, chaperones and apoptosis-related genes, the VSHE group showed the highest values and the VSHP the lowest, whereas the application of sustained swimming partially equalized those differences. Diet composition modulated the enzyme activity, prioritizing the superoxide dismutase and catalase in the HE-fed groups and the glutathione-related enzymes in the HP groups. Exercise also altered enzyme activity, but in a tissue-dependent manner. Overall, the redox balance in gilthead sea bream juveniles can be affected by diet composition and sustained swimming. However, the response will partly depend on the interaction between these factors and the tissue studied. Therefore, the combination of an adequate diet and sustained exercise could be used in fish production to improve the physiological redox status.

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Section: Discussionsupporting

confidence: 92%

Section: Effect Of Diet On Oxidative Stress Statussupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Interaction between the Effects of Sustained Swimming Activity and Dietary Macronutrient Proportions on the Redox Status of Gilthead Sea Bream Juveniles (Sparus aurata L.)

et al. 2022

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“…Karaman et al [ 30 ] investigated the effects of high fat diet on the thiol-disulfide metabolism of the rats. They found that the compensatory response failed in the glutathione and the impairment of redox imbalance in thiol/disulfide metabolism after 180 days alimentary.…”

Section: Discussionmentioning

confidence: 99%

Investigation of Thiol/Disulfide Balance in Obese Rats with Non-Alcoholic Fatty Liver Disease

Tursun

Gülerman

Gazyagci

et al. 2021

Pediatr Gastroenterol Hepatol Nutr

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Purpose Due to the increasing prevalence of obesity worldwide, non-alcoholic fatty liver disease (NAFLD) has reached epidemic dimensions over time. NAFLD is the most common cause of childhood chronic liver disease. There is a relationship between NAFLD and oxidative stress. This study aims to investigate the changes in thiol/disulfide homeostasis parameters to determine the oxidant/antioxidant balance in obese rats with diet-induced NAFLD and healthy rats. Methods Twelve Wistar albino rats were used in this study. Experimentally produced NAFLD obese rats (n=6) and healthy rats were compared. Experimental NAFLD model was created with a special fatty liver diet (Altromin® C1063, Fatty Liver Diet, Exclusivet, Lage, Germany). The biochemical and histopathological features of the groups, as well as serum thiol/disulfide homeostasis parameters, were analyzed and compared. Results In the experimentally induced NAFLD rat model, they gained more weight than the control group. Steatosis (at least grade 2) occurred in all rats fed with special fatty liver diet for 12 weeks. Histopathologically, no high-grade inflammation was observed in rats with experimental NAFLD after feeding a diet for 12 weeks. Results revealed that aspartate transaminase and alanine transaminase levels were high, albumin levels were low, oxidant stress parameters increased, and antioxidant thiol groups decreased. Conclusion Experimental NAFLD is characterized by increased oxidant stress accompanying fatty tissue in the liver. Analysis of thiol/disulfide homeostasis parameters in NAFLD can be used in further studies to develop effective treatment options.

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“…Sulfhydryls are characterized as SH‐ thiol groups that act as antioxidants in the body, such as glutathione and when present in proteins and other compounds can be oxidized in the presence of free radicals (Halliwell & Gutteridge, 2007). Karaman and cols demonstrated that rats submitted to a high‐fat diet presented a recover of glutathione levels at 90 days, but not at 30 or 180 days, as well as an improvement in glutathione reductase (Karaman, Novgorodtseva, & Yan, 2013). In our study, the sulfhydryl content in liver and plasma of treated animals were increased, which it is possible a compensatory response of antioxidant system stimulated by the consumption of fat and cholesterol.…”

Section: Discussionmentioning

confidence: 99%

Effect of cassava flour on the lipidic and redox profile of Wistar rats with dyslipidemia

et al. 2020

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Cardiovascular diseases account for 17.3 million deaths per year worldwide and this number is estimated to double in the next 15 years (WHO, 2013). It is now known that there is a strong relationship between cardiovascular diseases and genetic, environmental, and lifestyle factors. When these factors coexist with risk factors for these diseases, the risk of coronary artery disease (CAD) increases exponentially (Castro, Vidigal, Franceschini, Priore, & Pelúzio, 2004). The main risk factors associated with these diseases are hypertension, high total cholesterol, reduced HDL cholesterol, smoking, Diabetes Mellitus type 2, and age (Cardiologia, 2017).

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Effects on Alimentary High-Fat Diet on Thiol Disulfide Homeostasis in Rats

Cited by 5 publications

References 6 publications

Interaction between the Effects of Sustained Swimming Activity and Dietary Macronutrient Proportions on the Redox Status of Gilthead Sea Bream Juveniles (Sparus aurata L.)

Interaction between the Effects of Sustained Swimming Activity and Dietary Macronutrient Proportions on the Redox Status of Gilthead Sea Bream Juveniles (Sparus aurata L.)

Investigation of Thiol/Disulfide Balance in Obese Rats with Non-Alcoholic Fatty Liver Disease

Effect of cassava flour on the lipidic and redox profile of Wistar rats with dyslipidemia

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