Effects on blood pressure of caffeic acid analogues isolated from Salviae Miltiorrhizae Radix in rats with adenine‐induced renal hypertension

Yokozawa, Takako; Zhou, Jia; Oura, Hikokíchi; Tanaka, Takashi; Nonaka, Gen‐ichiro; Nishioka, Itsuc

doi:10.1002/ptr.2650090205

Cited by 17 publications

(10 citation statements)

References 22 publications

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“…We hypothesized that the improved kidney function in MLB-treated mice was related (at least in part) to the enriched Odoribacter genus via a cardiovascular pathway [37]. We did not monitor blood pressure during our study, but MLB's antihypertensive effect has been reported [40,41]. Our study observed, for the first time, a potential connection between MLB's antihypertensive effect and the gut microbiota.…”

Section: Discussionmentioning

confidence: 86%

Magnesium lithospermate B improves the gut microbiome and bile acid metabolic profiles in a mouse model of diabetic nephropathy

et al. 2018

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Magnesium lithospermate B (MLB) is a new drug marketed in China to treat angina, but its low oral bioavailability limits its clinical application to the intravenous route. Paradoxically, orally administered low-dose MLB was found to alleviate kidney injury in diabetic nephropathy (DN) rats, but its mechanism of action remains unknown. In recent years, the kidney-gut axis has been suspected to be involved in kidney damage pathogenesis, potentially representing a non-classical pathway for pharmacologic intervention. To ascertain whether MLB targets the kidney-gut axis, streptozotocin (STZ)-treated mice were prepared as a mouse model of DN. The STZ mice were treated with MLB (50 mg kg d, p.o.) for 8 weeks. Twenty-four-hour urinary albumin was detected to mirror kidney function. At week 4, 6, 8, feces were collected; bile acids (BAs) were quantified to examine the alterations in the BA metabolic profiles, and bacterial 16S rRNA gene fragments were sequenced to identify alterations in gut microbial composition. In STZ mice, 24-h urinary albumin levels and total fecal BAs, especially cholic acids (CAs) and deoxycholic acids (DCAs) were greatly increased, and the gut microbiome was dramatically shifted compared with control mice. Oral administration of MLB significantly decreased 24-h urinary albumin levels and total BAs, CAs and DCAs, and reversed CA:TCA (taurocholic acid) and DCA:CA ratios. It also changed the microbiome composition in STZ mice based on operational units. Thus the therapeutic effect of MLB on kidney injury might be attributed (at least partially) to its ability to modulate the disordered gut microbiome and BA metabolism.

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Section: Discussionmentioning

confidence: 86%

Magnesium lithospermate B improves the gut microbiome and bile acid metabolic profiles in a mouse model of diabetic nephropathy

et al. 2018

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“…72 Plantderived caffeic acid analogues fed to rats with adenine-induced renal hypertension were able to lower systolic blood pressure. 73 Grape polyphenolics administered to rats reduced thrombin-induced platelet aggregation 74 and grape juice inhibited platelet activity and thrombosis in stenosed canine coronary arteries. 75 Phenolic acids, such as caffeic acid, have been shown to protect cultured endothelial cells against the cytotoxic effects of oxLDL, possibly by blocking the intracellular signalling triggered by oxLDL.…”

Section: Other Biological Activitymentioning

confidence: 99%

Chemistry And Biological Effects Of Dietary Phenolic Compounds: Relevance To Cardiovascular Disease

Morton

Caccetta

Puddey

et al. 2000

Clin Exp Pharma Physio

336

177

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1. There has been considerable recent interest in the possibility that increased intake of dietary anti-oxidants may protect against cardiovascular disease. This is partly due to the knowledge that oxidative events in vivo may play a role in the pathogenesis of atherosclerosis. 2. While dietary anti-oxidants, such as vitamins E and C, have received considerable attention in this regard, relatively little is known about a similar anti-oxidant role for plant-derived polyphenolic compounds, such as the flavonoids and phenolic acids. A review of the distribution, bioavailability and biological activity of these compounds suggests that they may have a physiological role as anti-oxidants. 3. Human trials on the anti-oxidant effects of beverages rich in polyphenolics, such as red wine, fruit juice or tea, have been limited and results are, at present, inconclusive. This is due, in part, to poor methodologies available to measure oxidative damage in vivo. 4. There is a sound rationale for considering polyphenolics as important contributors to the dietary anti-oxidant intake derived from fruits and vegetables. However, continuing research is needed using appropriate biomarkers of oxidant damage in vivo before these compounds can be conclusively considered as dietary anti-oxidants with nutritional benefit.

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“…13,14) Different studies have shown that Sal B has a variety of biological activities including anti-oxidation, 15,16) antifibrotic, 17) and myocardial salvage effects 18) ; it also prevents hepatitis and uremia, 19) and improves blood circulation and renal function. [20][21][22][23][24][25] Considering their prominent pharmacological activities and high content in Danshen, both TSIIA and Sal B have been selected as marker components for the quality control of Danshen and many other medicinal preparations containing Danshen in the 2005 edition of Chinese Pharmacopoeia. 6,12,26) The chemical structures of TanIIA and Sal B are shown in Fig.…”

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confidence: 99%

Pharmacokinetic Interaction between Tanshinones and Polyphenolic Extracts of Salvia miltinorrhiza BUNGE after Intravenous Administration in Rats

Guo

Zhang

Tang

et al. 2008

Biological & Pharmaceutical Bulletin

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The dry roots of Salvia miltiorrhiza, also called "Danshen" in Chinese, are a well-known traditional Chinese medicinal herb. Because of its better performance and fewer side effects confirmed during the long-time clinical use, Danshen is widely used in traditional Chinese medicinal preparations to treat a number of coronary heart diseases, especially angina pectoris and myocardial infarction. [1][2][3][4] At present, a variety of Danshen products are commercially available, such as Fufang Danshen Tablets and Fufang Danshen Dripping pills, which are the two most commonly used ones in China and these have been officially listed in the Chinese Pharmacopoeia 2005. 5)According to their chemical structures, the major bioactive constituents in S. miltiorrhiza BUNGE can be classified into two groups: the tanshinone compounds, which belong to a group of lipid-soluble diterpenoids, and water-soluble polyphenolic compounds.6) The major lipophilic components are cryptotanshinone, tanshinone I and tanshinone IIA (TSIIA). Pharmacological tests have revealed that TSIIA possesses a variety of pharmacological activities including antioxidant effects, 7) prevention of angina pectoris and myocardial infarction, 8) as well as antineoplastic, 9) anticancer, 10,11) and anti-inflammatory effects.12) The major hydrophilic components include danshensu, protocatechuic aldehyde and salvianolic acid B (Sal B). Sal B is the most common component in the Salvia species and the most abundant in their aqueous extracts. 13,14) Different studies have shown that Sal B has a variety of biological activities including anti-oxidation, 15,16) antifibrotic, 17) and myocardial salvage effects 18) ; it also prevents hepatitis and uremia, 19) and improves blood circulation and renal function. [20][21][22][23][24][25] Considering their prominent pharmacological activities and high content in Danshen, both TSIIA and Sal B have been selected as marker components for the quality control of Danshen and many other medicinal preparations containing Danshen in the 2005 edition of Chinese Pharmacopoeia. 6,12,26) The chemical structures of TanIIA and Sal B are shown in Fig. 1. Recently, Song et al. 27) showed that the pharmacokinetics of cryptotanshinone and TSIIA in rats after oral intra-gavage of an extract of tanshinones was significantly affected by the co-present tanshinones. Also, Sal B had a lower effective concentration in vitro angiogenesis study than the crude extract. 28) In clinical practice, most Danshen products used consist of tanshinone and polyphenolic extracts at the same time.5) However, there have been no reports of pharmacokinetic interactions between tanshinones and polyphenolic extracts of S. miltiorrhiza BUNGE in vivo.To date, several methods have been established for the de- The objective of this study was to investigate the interaction between tanshinones and polyphenolic extracts of Salvia miltiorrhiza BUNGE in rats. The rats in the medium dose groups were given an intravenous administration of 10 mg/kg tanshinones extract-loaded emulsi...

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Effects on blood pressure of caffeic acid analogues isolated from Salviae Miltiorrhizae Radix in rats with adenine‐induced renal hypertension

Cited by 17 publications

References 22 publications

Magnesium lithospermate B improves the gut microbiome and bile acid metabolic profiles in a mouse model of diabetic nephropathy

Magnesium lithospermate B improves the gut microbiome and bile acid metabolic profiles in a mouse model of diabetic nephropathy

Chemistry And Biological Effects Of Dietary Phenolic Compounds: Relevance To Cardiovascular Disease

Pharmacokinetic Interaction between Tanshinones and Polyphenolic Extracts of Salvia miltinorrhiza BUNGE after Intravenous Administration in Rats

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