2010
DOI: 10.1093/bja/aeq173
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Effects on coagulation of balanced (130/0.42) and non-balanced (130/0.4) hydroxyethyl starch or gelatin compared with balanced Ringer’s solution: an in vitro study using two different viscoelastic coagulation tests ROTEM™ and SONOCLOT™

Abstract: Both ROTEM and SONOCLOT are sensitive tests for the detection of impaired blood coagulation due to haemodilution. There are fewer effects on blood coagulation using crystalloids compared with colloids. The effects of GEL and HES are similar. There is no difference between balanced HES 130/0.42 and non-balanced HES 130/0.4.

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Cited by 56 publications
(52 citation statements)
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“…The instrument used for this study was chosen over thromboelastography because more significant changes were found during previous in vitro testing in horses 14. Coagulation effects were not as prominent using viscoelastic testing as previous in vitro work in horses14 and humans 18, 27. In this study, the only variable that changed associated with treatment was PF.…”
Section: Discussionmentioning
confidence: 99%
“…The instrument used for this study was chosen over thromboelastography because more significant changes were found during previous in vitro testing in horses 14. Coagulation effects were not as prominent using viscoelastic testing as previous in vitro work in horses14 and humans 18, 27. In this study, the only variable that changed associated with treatment was PF.…”
Section: Discussionmentioning
confidence: 99%
“…In the present study, three different activators (InTEM, ExTEM and FibTEM) were used to examine the intrinsic and extrinsic coagulation pathways, platelet function and fibrinogen--fibrin interaction. Previous studies showed that HES, 20% mannitol and 3% HS caused coagulation impairment (7,11,12). When we searched the literature, we found two deficiencies:…”
Section: Discussionmentioning
confidence: 95%
“…Finally, there was no control group for balanced solutions. It was however revealed that carrier solution had little impact on platelet aggregation and clot formation [15,27].…”
Section: Limitations Of the Studymentioning
confidence: 99%