2001
DOI: 10.1053/rmed.2001.1124
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Effects on diffusing capacity and ventilation–perfusion relationships of budesonide inhalations for 2 months in chronic obstructive pulmonary disease (COPD)

Abstract: Forced expiratory volumes are reduced in chronic obstructive pulmonary disease (COPD), mainly as a result of inflammatory and morphological changes in the small airways (with a diameter < 2 mm) and in the alveoli. However, it is difficult to detect minor changes in small airways by spirometry measurements. To study the effects on small airways of inhaled corticosteroids (ICS), 19 stable COPD patients were investigated; 15 were evaluated by ventilation-perfusion (V(A)/Q) relationships, assessed by the multiple … Show more

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Cited by 12 publications
(5 citation statements)
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“…It is known that structural changes in the peripheral lung cannot be adequately represented by standard spirometric measurements, while diffusing capacity can be used for this purpose. Our observational results are in line with those of randomized controlled studies that showed an improvement of diffusing capacity during treatment with ICS, 38 whereas spirometric values were not found to be significantly altered. [39][40][41] Beyond the effects of ICS on the selected outcome measures, one of the findings of our study was the identification of predictors of ICS therapy.…”
supporting
confidence: 91%
“…It is known that structural changes in the peripheral lung cannot be adequately represented by standard spirometric measurements, while diffusing capacity can be used for this purpose. Our observational results are in line with those of randomized controlled studies that showed an improvement of diffusing capacity during treatment with ICS, 38 whereas spirometric values were not found to be significantly altered. [39][40][41] Beyond the effects of ICS on the selected outcome measures, one of the findings of our study was the identification of predictors of ICS therapy.…”
supporting
confidence: 91%
“…It has been suggested that changes in DL CO over time may be at least in part affected by changes in the airway caliber induced by bronchodilators [25]. In a small study, ICS treatment for 2 months was accompanied by a significant increase in DL CO likely because of an improvement in the small airway diameter, thought due to reduced inflammation of bronchioli and alveoli [26]. These changes can induce an improvement in the lung regional hypoxemic vasoconstriction [27], and DL CO is a global measure of the number of perfused capillaries and ventilated alveoli and therefore is sensitive to microvascular changes [28].…”
Section: Doi: 101159/000512728mentioning
confidence: 97%
“…inequality. Most MIGET studies in COPD were carried out in the 20 th century [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] . At the time, COPD was understood as both alveolar destruction (emphysema) and long-term airway inflammation (chronic bronchitis) in variable combination.…”
Section: Chronic Obstructive Pulmonary Disease (Copd)mentioning
confidence: 99%