Effects on pain and cognition of transcranial direct current stimulation over the dorsolateral prefrontal cortex in women with chronic migraine

Aranha, Renata Emanuela Lyra de Brito; Torro-Alves, Nelson; Andrade, Suellen Marinho; Oliveira, Eliane Araújo de; Silva, Bruna Nadiely Victor da; Fonsêca, Égina Karoline Gonçalves da; Santos, Gabriela Emílio Lima dos; Guedes, Natália Monteiro; Silva, Tatyanne dos Santos Falcão; Fernández‐Calvo, Bernardino

doi:10.1016/j.neucli.2022.07.005

Cited by 8 publications

(4 citation statements)

References 18 publications

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“…As reported in the previous study [ 51 , 52 ], pain is a complex and subjective experience that is shaped by evaluation and judgments about afferent sensory information in multiple brain regions, including the prefrontal gyrus, basal ganglia, sensorimotor cortex, and temporal-occipital cortex. Among these regions, the hippocampus, parahippocampus, and amygdala are mainly associated with the long-range memory of pain [ 53 ], the lateral parietal-temporal-occipital is involved in the integration of multisensory information during migraine attacks [ 54 ], while the prefrontal gyrus and motor cortex are largely involved in the cognitive, emotional, and motivational dimensions of pain [ 55 ]. Therefore, a plausible explanation regarding the current findings is that the long-term negative pain memories caused structural disruptions of the hippocampus/parahippocampus, interfered with the integration of multisensory information in the lateral parietal-temporal-occipital cortex and further affected the emotional and cognitive functions of the MwoA patients, resulting in the structural plasticity of the motor and prefrontal cortices.…”

Section: Discussionmentioning

confidence: 99%

Parahippocampus hypertrophy drives gray matter morphological alterations in migraine patients without aura

et al. 2023

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Background The aberrance of gray matter morphology in migraineurs has been widely investigated. However, it remains largely unknown whether there are illness duration-related hierarchical changes in the gray matter structure. Methods A total of 86 migraine without aura (MwoA) patients and 73 healthy controls were included. The Voxel-Based Morphometry approach was utilized to compare the gray matter volume (GMV) differences between MwoA patients and healthy controls. The Structural Covariance Network analysis was conducted to quantify the cross-regional synchronous alterations of gray matter structure in MwoA patients. The Causal Structural Covariance Network analysis was performed to describe the progressive and hierarchical changes in the gray matter network of patients in the pathological progression of migraine. Results MwoA patients had duration-stage related GMV hypertrophy in the left parahippocampus, as well as synergistic GMV aberrance in the parahippocampus and the medial inferior temporal gyrus and cerebellum. Moreover, the GMV alteration of the parahippocampus, and the surrounding hippocampus, amygdala, and bilateral anterior cerebellum, preceded and causally influenced the morphological changes of lateral parietal-temporal-occipital gyrus, as well as the motor cortex and prefrontal gyrus with the increasing illness duration in MwoA patients. Conclusion The current study indicated that gray matter structural alterations in the medial inferior temporal gyrus, especially the parahippocampus, is a critical pathological characteristic in MwoA patients, which drives the gray matter structure alteration of other regions. These findings provide further evidence for understanding the progressive gray matter morphological changes in migraine and may facilitate the development of neuromodulation therapies targeting this procession.

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Section: Discussionmentioning

confidence: 99%

Parahippocampus hypertrophy drives gray matter morphological alterations in migraine patients without aura

et al. 2023

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“…Since the introduction of this technology in its current form, positive results have been reported in psychiatry ( Blumberger et al, 2012 ; Demirtas-Tatlidede et al, 2013 ; Martin et al, 2011 ) and neurorehabilitation ( Hernandez-Pavon and Harvey, 2019 ; Lindenberg et al, 2012 ). tDCS has also been suggested as a promising therapy for patients with several chronic pain conditions, including fibromyalgia ( Villamar et al, 2013 ), pain due to traumatic spinal cord injury ( Fregni et al, 2006 ; Soler et al, 2010 ), chronic pelvic pain ( Divandari et al, 2019 ; Fenton et al, 2009 ), refractory orofacial pain ( Antal and Paulus, 2011 ), postherpetic neuralgia ( DosSantos et al, 2012 ), painful diabetic polyneuropathy ( Kim et al, 2013 ), chronic neuropathic pain following a burn injury ( Portilla et al, 2013 ), trigeminal neuralgia ( Hagenacker et al, 2014 ), lower back pain ( Schabrun et al, 2014 ), and migraines ( Antal et al, 2011 ; de Brito Aranha et al, 2022 ; Viganò et al, 2013 ). The modulatory effects of tDCS are reversible and painless, and its portability represents the possibility of home-based pain treatment ( Nitsche et al, 2008 ; Pacheco-Barrios et al, 2020 ).…”

Section: Pathophysiology Of Pth and Associated Mechanisms After Tbimentioning

confidence: 99%

Inflammation, brain connectivity, and neuromodulation in post-traumatic headache

da Silva Fiorin,

do Espírito Santo,

Da Silva

et al. 2024

Brain, Behavior, & Immunity - Health

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“…57 There is emerging evidence suggesting that stimulation of the DLPFC region may effectively reduce pain severity in CPP. [58][59][60] Contrastingly, tDCS targeting the M1 region is more commonly used in CPP treatments, 61 with studies indicating its short, medium, and long-term effects on pain intensity. 62 A recent study highlighted the superior effectiveness of tDCS when applied to the M1 region over the DLPFC in patients with fibromyalgia.…”

Section: Locus Of Stimulation For Chronic Painmentioning

confidence: 99%

Combining Transcranial Direct Current Stimulation With Non-Invasive Interventions for Chronic Primary Pain: A Systematic Review and Meta-Analysis

Lyra de Brito Aranha,

Nascimento,

Sampaio

et al. 2024

Neurorehabil Neural Repair

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Background A growing number of studies has combined transcranial direct current stimulation (tDCS) with other non-invasive non-pharmacological therapies (NINPT) to enhance effects in pain reduction. However, the efficacy of these combined approaches in treating chronic primary pain (CPP) warrants thorough investigation. Objective This study aims to evaluate the efficacy of tDCS in conjunction with other NINPT in alleviating pain severity among CPP patients. Methods We conducted a systematic search for randomized controlled trials (RCTs) comparing the efficacy of tDCS combined with NINPT against control treatments in adult CPP patients. The search spanned multiple databases, including PubMed, EMBASE, LILACS, Scopus, Web of Science, and CENTRAL. Results Our systematic review included 11 RCTs with a total of 449 participants. In our meta-analysis, which comprised 228 participants receiving active-tDCS and 221 receiving sham-tDCS, we found a significant reduction in pain intensity (Standard Mean Difference = −0.73; 95% Confidence Interval (CI) = −1.18 to −0.27; P = .002) with the use of active-tDCS combined with NINPT. Conclusion These findings substantiate the therapeutic potential of combining tDCS with other NINPT, highlighting it as an effective treatment modality for reducing pain intensity in CPP patients.

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Effects on pain and cognition of transcranial direct current stimulation over the dorsolateral prefrontal cortex in women with chronic migraine

Cited by 8 publications

References 18 publications

Parahippocampus hypertrophy drives gray matter morphological alterations in migraine patients without aura

Parahippocampus hypertrophy drives gray matter morphological alterations in migraine patients without aura

Inflammation, brain connectivity, and neuromodulation in post-traumatic headache

Combining Transcranial Direct Current Stimulation With Non-Invasive Interventions for Chronic Primary Pain: A Systematic Review and Meta-Analysis

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