Effects on sleep architecture of pindolol, paroxetine and their combination in healthy volunteers

Bell, Caroline; Wilson, Sue; Rich, Ann; Bailey, J. A.; Nutt, David

doi:10.1007/s00213-002-1314-9

Cited by 16 publications

(2 citation statements)

References 45 publications

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“…Furthermore, REM and NREM overlap may also explain the striking preponderance of ST in childhood because they have a greater proportion of both N3 and REM sleep. Intriguingly, the antidepressant medication paroxetine, an agent that can both induce SW [31] and treat ST [189,190], is a potent REM suppressor [196]. Thus, if ST were due to pathological REM and NREM overlap, it would expected that paroxetine would block these phenomena.…”

Section: Alternative Theory Of Sleep Terrorsmentioning

confidence: 99%

Parasomnias: An Updated Review

2012

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Parasomnias are abnormal behaviors emanating from or associated with sleep. Sleepwalking and related disorders result from an incomplete dissociation of wakefulness from nonrapid eye movement (NREM) sleep. Conditions that provoke repeated cortical arousals, or promote sleep inertia lead to NREM parasomnias by impairing normal arousal mechanisms. Changes in the cyclic alternating pattern, a biomarker of arousal instability in NREM sleep, are noted in sleepwalking disorders. Sleep-related eating disorder (SRED) is characterized by a disruption of the nocturnal fast with episodes of feeding after an arousal from sleep. SRED is often associated with the use of sedative-hypnotic medications; in particular, the widely prescribed benzodiazepine receptor agonists. Recently, compelling evidence suggests that nocturnal eating may in some cases be a nonmotor manifestation of Restless Legs Syndrome (RLS). rapid eye movement (REM) Sleep Behavior Disorder (RBD) is characterized by a loss of REM paralysis leading to potentially injurious dream enactment. The loss of atonia in RBD often predates the development of Parkinson's disease and other disorders of synuclein pathology. Parasomnia behaviors are related to an activation (in NREM parasomnias) or a disinhibition (in RBD) of central pattern generators (CPGs). Initial management should focus on decreasing the potential for sleep-related injury followed by treating comorbid sleep disorders. Clonazepam and melatonin appear to be effective therapies in RBD, whereas paroxetine has been reported effective in some cases of sleep terrors. At this point, pharmacotherapy for other parasomnias is less certain, and further investigations are necessary.Keywords Parasomnia . Sleepwalking . Sleep terrors . REM sleep behavior disorder . Restless legs syndrome Classification of ParasomniasParasomnias are typically classified by the sleep state from which they arise: non-rapid eye movement sleep (NREM) and rapid eye movement sleep (REM) (see Table 1 NREM parasomnias include: confusional arousals, sleepwalking disorder, and sleep terrors. These behaviors arise when the cortex incompletely arouses from deep NREM sleep, often due to comorbid conditions that provoke repeated arousal or promote sleep inertia. Changes in the cyclic alternating pattern, a biomarker of arousal instability in NREM sleep, are noted in sleepwalking and related disorders [3].Sleep-related eating disorder (SRED) is currently classified in the International Classification of Sleep Disorders, 2nd edition (ICSD-2) under "Other Parasomnia" [1]. However the vast majority of SRED cases emanate from NREM [4], and the complex amnestic behaviors with ambulation are striking similar to sleepwalking [5]. Furthermore, both SRED and sleepwalking are frequently triggered by sedating agents in the setting of underlying motor restlessness [6]. Thus, considering these similarities, SRED will be reviewed immediately after NREM parasomnias.REM sleep behavior disorder is the most clinically relevant REM parasomnia. The loss of atoni...

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Section: Alternative Theory Of Sleep Terrorsmentioning

confidence: 99%

Parasomnias: An Updated Review

2012

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“…Metoprolol, pindolol, and atenolol have been shown to decrease sleep continuity (Foral et al, 2003;Schweitzer, 2005). Both pindolol and paroxetine reduced REM sleep and SWS more than with either medication alone or placebo (Bell et al, 2003). Healthy, nondepressed males taking pindolol (2.5 mg) were studied with and without paroxetine (20 mg/day).…”

Section: Antiadrenergic Medicationsmentioning

confidence: 99%

Alcohol, toxins, and medications as a cause of sleep dysfunction

Conroy

Brower

2011

Handbook of Clinical Neurology

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Current awareness in human psychopharmacology

2003

Human Psychopharmacology

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of human psychopharmacology. Each bibliography is divided into 18 sections: 1 Books, Reviews & Symposia; 2 General; 3 Psychotropic Drugs ‐ General; Antidepressive Agents: 4 Tricyclics; 5 Monoamine Oxidase Inhibitors; 6 Serotonergics; Euthymic Agents: 7 Lithium; Tranquillizing Agents: 8 Major; 9 Minor & Hypnotics; 10 Analeptic Agents; 11 Anticonvulsant Agents; 12 Drugs of Abuse; 13 Transmitters, Receptors, Metabolites & Modulating Agents; 14 Neuropeptides; 15 Psychoneuroendocrinology; 16 Psychoneuroimmunology; 17 Behavioural Genetics; 18 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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Effects on sleep architecture of pindolol, paroxetine and their combination in healthy volunteers

Cited by 16 publications

References 45 publications

Parasomnias: An Updated Review

Parasomnias: An Updated Review

Alcohol, toxins, and medications as a cause of sleep dysfunction

Current awareness in human psychopharmacology

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