Effects on the Urinary Level of γ-Carboxyglutamic Acid Caused by the Administration of Antibiotics with N-Methyl Thiotetrazole Side Chains to Patients with Infectious Diseases

Abstract

A comparative study was conducted of the urinary level of γ-carboxyglu-tamic acid (γ-Gla) in patients with infectious diseases to investigate the mechanism of hemorrhagic diathesis occurrence resulting in post-administrative side effects of ceph-em-group antibiotics. The results showed that the group of administered antibiotics with N-methyl thiotetrazole (NMTT) side chains exhibited decreases in the urinary level of γ-Gla. Especially, in the aged group of patients (over 65) with non-carcinoma infectious diseases, significant decreases in the urinary level of γ-Gla were observed. From the above, it is considered that the administration of antibiotics with N MTT side chains has an effect of prohibiting the vitamin K function.