Effects on ventricular function of disopyramide, procainamide and quinidine as determined by radionuclide angiography

Wisenberg, Gerald; Zawadowski, Andrew G.; Gebhardt, Vernon A.; Prato, Frank S.; Goddard, Michele D.; Nichol, P. M.; Rechnitzer, Peter A.; Gryfe-Becker, Brenda

doi:10.1016/0002-9149(84)90082-1

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1985

1992

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Cited by 28 publications

(2 citation statements)

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“…'7' 18 Likewise, despite the fact that quinidine has been in use for several decades, quantitative assessment of its hemodynamic effects in patients with depressed cardiac function is sparse. 19 ' 20 The present investigation was initiated as an ancillary study of a multicenter trial comparing the ventricular antiarrhythmic effects of sotalol and quinidine.…”

mentioning

confidence: 99%

The hemodynamic effects of sotalol and quinidine: analysis by use of rest and exercise gated radionuclide angiography.

et al. 1987

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mentioning

confidence: 99%

The hemodynamic effects of sotalol and quinidine: analysis by use of rest and exercise gated radionuclide angiography.

et al. 1987

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“…Hemodynamic side effects of both drugs were tested in many studies in different species and condi tions. Results for humans with and without impaired ventricular function [18], with or without stress test [7,20] and laboratory studies do not yield consistent results [5,6,12]. Ventricular contractility is impaired by both drugs in a dose-dependent fashion.…”

Section: Discussionmentioning

confidence: 99%

Hemodynamic Effects of Mexiletine and Disopyramide after Cardioplegic Arrest

Moritz¹,

Eckersberger²,

Losert³

et al. 1989

Eur Surg Res

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To study the hemodynamic side effects of mexiletine and disopyramide when administered before cardioplegic arrest 15 dogs underwent sham cardiac surgery with a 90-min period of aortic cross-clamping. 5 dogs served as control, 5 were given 8 mg/kg/day mexiletine and another five 11 mg/kg/day disopyramide for 1 week before surgery. On the day of surgery a continuous infusion was started. After reperfusion treated animals exceeded their preischemic blood pressure and regained their preoperative cardiac output. Compared to control animals left ventricular work was higher in the treated animals after reperfusion. The two tested type I antiarrhythmics tend to add to myocardial protection when given before cardioplegic arrest and do not exhibit negative inotropic side effects.

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