Efferent connections of the centrum medianum of the cat thalamus revealed by autoradiography

Sotnichenko, T. S.; Istomina, L. A.

doi:10.1007/bf01052312

Cited by 1 publication

(1 citation statement)

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“…Any report using or reviewing tract tracing was obtained and reviewed, and any connections with the STN documented. The inclusion criteria were reports written in English (n = 4 excluded ( Makoev, 1981; L'vovich, 1978; Oleshko, 1985; Sotnichenko and Istomina, 1984 )), only involving mammals (n = 3 excluded ( Belekhova, 1991; Brauth et al, 1978; Martínez-Marcos et al, 1999 )). Four articles were unobtainable ( Jackson and Crossman, 1981a; Nauta and Cole, 1974; Nauta and Domesick, 1984; Saper and Loewy, 1982 ).…”

Section: Methodsmentioning

confidence: 99%

Confirmation of functional zones within the human subthalamic nucleus: Patterns of connectivity and sub-parcellation using diffusion weighted imaging

et al. 2012

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The subthalamic nucleus (STN) is a small, glutamatergic nucleus situated in the diencephalon. A critical component of normal motor function, it has become a key target for deep brain stimulation in the treatment of Parkinson's disease. Animal studies have demonstrated the existence of three functional sub-zones but these have never been shown conclusively in humans. In this work, a data driven method with diffusion weighted imaging demonstrated that three distinct clusters exist within the human STN based on brain connectivity profiles. The STN was successfully sub-parcellated into these regions, demonstrating good correspondence with that described in the animal literature. The local connectivity of each sub-region supported the hypothesis of bilateral limbic, associative and motor regions occupying the anterior, mid and posterior portions of the nucleus respectively. This study is the first to achieve in-vivo, non-invasive anatomical parcellation of the human STN into three anatomical zones within normal diagnostic scan times, which has important future implications for deep brain stimulation surgery.

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Section: Methodsmentioning

confidence: 99%