Efferent connections of the parvalbumin‐positive (PV1) nucleus in the lateral hypothalamus of rodents

Celio, Marco R.; Babalian, A.; Ha, Quan Hue; Eichenberger, Simone; Clément, Laurence; Marti, Christiane; Saper, Clifford B.

doi:10.1002/cne.23344

Cited by 24 publications

(45 citation statements)

References 67 publications

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“…The parvalbumin-immunopositive neurons of the PV1-nucleus project to a circumscribed longitudinal column of neurons, which is located in the midbrain, ventral to the aqueduct [12]. The question that now arises is whether the much larger population of Foxb1-EGFP-positive neurons likewise projects to this column, or to a functionally adjoining one in the PAG.…”

Section: Discussionmentioning

confidence: 99%

Coaxiality of Foxb1- and parvalbumin-expressing neurons in the lateral hypothalamic PV1-nucleus

Bilella

Álvarez-Bolado

Celio

2014

Neuroscience Letters

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h i g h l i g h t s• Foxb1-expressing neurons lie in the lateral hypothalamic PV1-nucleus.• Coaxial distribution of Foxb1-and PV-expressing neurons in the PV1-nucleus.• Foxb1-expressing neurons outnumber PV-expressing ones in the PV1-nucleus.• Only a small proportion of the two neural populations co-express both markers.In the ventrolateral hypothalamus, the PV1-nucleus is defined by its population of parvalbuminexpressing neurons. During embryogenesis, the ventrolateral hypothalamus is colonized also by Foxb1-expressing neurons. In adult Foxb1-EGFP mice, many immunofluorescent neurons were found within the region that is occupied by the PV1-nucleus. They formed a cloud around the axial cord of the parvalbumin-immunopositive cells, which they greatly outnumber (3:1). Only a small proportion of the neurons in the PV1-nucleus co-expressed both parvalbumin and Foxb1. In the light of these findings, a redesignation of this lateral hypothalamic structure as the PV1-Foxb1 nucleus would more accurately reflect its specific biochemical properties.

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Section: Discussionmentioning

confidence: 99%

Coaxiality of Foxb1- and parvalbumin-expressing neurons in the lateral hypothalamic PV1-nucleus

Bilella

Álvarez-Bolado

Celio

2014

Neuroscience Letters

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“…The nucleus is located in the tuberal part of the ventrolateral hypothalamus, between the optic tract and the fornix [5][6][7]. Experiments in which anterograde tracers, particularly Cre-recombinase-dependent viral ones, have been injected into PV-Cre or Foxb1-Cre mice, have revealed the parvafox nucleus to project mainly to the periaqueductal grey matter (PAG), and, more specifically, to the ventrolateral [8] and the dorsolateral [9] columns. Furthermore, in-situ hybridization has disclosed PV-expressing neurons of the parvafox nucleus to be glutamatergic and thus excitatory [10], in contrast to those in most other brain areas, such as the neocortex, the hippocampus and the cerebellum [11].…”

Section: Introductionmentioning

confidence: 99%

Reduction in 50-kHz call-numbers and suppression of tickling-associated positive affective behaviour after lesioning of the lateral hypothalamic parvafox nucleus in rats

Roccaro-Waldmeyer

Babalian

Müller

et al. 2016

Behavioural Brain Research

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h i g h l i g h t s• Wistar rats were tickled before and after excitotoxic lesioning of the lateral hypothalamic parvafox nucleus.• Ultrasonic vocalisations (USVs) that were emitted during the tickling of rats and their tendency to approach and follow the experimenter's hand were analysed.• Lesioning was considered successful if the number of parvalbuminimmunoreactive (PV-ir) cells in the area of the parvafox nucleus was reduced beyond a threshold level.• Rats with bilaterally successful lesions manifested the most profound surgery-associated reduction in the number of 50-kHz USVs and in the tendency to approach and follow the experimenter's hand.• Positive correlations were found between each of the four investigated parameters. g r a p h i c a l a b s t r a c tThe parvafox nucleus is located ventrolaterally in the lateral hypothalamic area (LHA). Its core and shell are composed of neurons expressing the calcium-binding protein parvalbumin (PV) and the transcription factor Foxb1, respectively. Given the known functions of the LHA and that the parvafox nucleus receives afferents from the lateral orbitofrontal cortex and projects to the periaqueductal gray matter, a functional role of this entity in the expression of positive emotions has been postulated.The purpose of the present study was to ascertain whether the deletion of neurons in the parvafox nucleus influenced the tickling-induced 50-kHz calls, which are thought to reflect positive affective states, in rats. To this end, tickling of the animals (heterospecific play) was combined with intracerebral injections of the excitotoxin kainic acid into the parvafox nucleus.The most pronounced surgery-associated reduction in 50-kHz call-numbers was observed in the group of rats in which, on the basis of PV-immunoreactive-cell counts in the parvafox nucleus, bilateral lesions had been successfully produced. Two other parameters that were implemented to quantify positive affective behaviour, namely, an approach towards and a following of the hand of the tickling * Corresponding author at: Institute of Anatomy, University of Fribourg, Rte A. Gockel 1, CH-1700 Fribourg, Switzerland.E-mail address: marco.celio@unifr.ch (M.R. Celio). 1Published in which should be cited to refer to this work.http://doc.rero.ch experimenter, were likewise most markedly suppressed in the group of rats with bilaterally successful lesions. Furthermore, positive correlations were found between each of the investigated parameters. Our data afford evidence that the parvafox nucleus plays a role in the production of 50-kHz calls in rats, and, more generally, in the expression of positive emotions.

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“…The efferent connections of the Parv-positive sub-population of neurons in the parvafox nucleus are almost exclusively directed toward a small cylindrical zone lying ventral to the aqueduct in the periaqueductal gray matter (PAG) (Celio et al, 2013). The targets of the Foxb1-cell subpopulation of the parvafox nucleus are likewise located in and around the PAG, but occur also in a few other cerebral sites (Bilella et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Parvalbumin-Neurons of the Ventrolateral Hypothalamic Parvafox Nucleus Receive a Glycinergic Input: A Gene-Microarray Study

Szabolcsi

Albisetti

Celio

2017

Front. Mol. Neurosci.

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The ventrolateral hypothalamic parvafox (formerly called PV1-Foxb1) nucleus is an anatomical entity of recent discovery and unknown function. With a view to gaining an insight into its putative functional role(s), we conducted a gene-microarray analysis and, armed with the forthcoming data, controlled the results with the Allen databases and the murine BrainStars (B*) database. The parvafox nucleus was specifically sampled by laser-capture microdissection and the transcriptome was subjected to a microarray analysis on Affymetrix chips. Eighty-two relevant genes were found to be potentially more expressed in this brain region than in either the cerebral cortex or the hippocampus. When the expression patterns of these genes were counterchecked in the Allen-Database of in-situ hybridizations and in the B*-microarray database, their localization in the parvafox region was confirmed for thirteen. For nine novel genes, which are particularly interesting because of their possible involvement in neuromodulation, the expression was verified by quantitative real time-PCR. Of particular functional importance may be the occurrence of glycine receptors, the presence of which indicates that the activity of the parvafox nucleus is under ascending inhibitory control.

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Efferent connections of the parvalbumin‐positive (PV1) nucleus in the lateral hypothalamus of rodents

Cited by 24 publications

References 67 publications

Coaxiality of Foxb1- and parvalbumin-expressing neurons in the lateral hypothalamic PV1-nucleus

Coaxiality of Foxb1- and parvalbumin-expressing neurons in the lateral hypothalamic PV1-nucleus

Reduction in 50-kHz call-numbers and suppression of tickling-associated positive affective behaviour after lesioning of the lateral hypothalamic parvafox nucleus in rats

Parvalbumin-Neurons of the Ventrolateral Hypothalamic Parvafox Nucleus Receive a Glycinergic Input: A Gene-Microarray Study

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