2020
DOI: 10.1101/2020.08.12.248799
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Efferent feedback enforces bilateral coupling of spontaneous activity in the developing auditory system

Abstract: SummaryIn the developing auditory system, spontaneous activity generated in the cochleae propagates into the central nervous system to promote circuit formation before hearing onset. Effects of the evolving peripheral firing pattern on spontaneous activity in the central auditory system are not well understood. Here, we describe the wide-spread bilateral coupling of spontaneous activity that coincides with the period of transient efferent modulation of inner hair cells from the medial olivochlear (MOC) system.… Show more

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Cited by 3 publications
(3 citation statements)
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References 77 publications
(131 reference statements)
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“…This is especially relevant when studying the progression of the patterns of spontaneous activity and the extent of correlation among different cortical regions. Spatial resolution values usually range from tens to hundreds of microns per pixel (supracellular resolution), whereas the typical frame rates span from 3 to 30 Hz with common values around 5 to 10 Hz (Hillman et al, 2011;Zhang et al, 2011b;Ackman et al, 2012Ackman et al, , 2014Xu et al, 2015;Babola et al, 2018;Gribizis et al, 2019;Ge et al, 2021;Ren and Komiyama, 2021;Wang et al, 2021). Overall, researchers configure the acquisition settings based on their specific scientific question and on empirical facts such as the intensity of the signal.…”
Section: Data Acquisition and Analysis Of Multi-region Neuronal Activitymentioning
confidence: 99%
See 1 more Smart Citation
“…This is especially relevant when studying the progression of the patterns of spontaneous activity and the extent of correlation among different cortical regions. Spatial resolution values usually range from tens to hundreds of microns per pixel (supracellular resolution), whereas the typical frame rates span from 3 to 30 Hz with common values around 5 to 10 Hz (Hillman et al, 2011;Zhang et al, 2011b;Ackman et al, 2012Ackman et al, , 2014Xu et al, 2015;Babola et al, 2018;Gribizis et al, 2019;Ge et al, 2021;Ren and Komiyama, 2021;Wang et al, 2021). Overall, researchers configure the acquisition settings based on their specific scientific question and on empirical facts such as the intensity of the signal.…”
Section: Data Acquisition and Analysis Of Multi-region Neuronal Activitymentioning
confidence: 99%
“…Bleaching, slow baseline fluctuations and background signal are usually corrected using algorithms that substract them from the raw signal. Motion artifacts in the horizontal plane are often minimized making use of alignment algorithms or discarding movement epochs (Ackman et al, 2014;Saxena et al, 2020;Wang et al, 2021). Conversely, some other factors, such as autofluorescence, are not strong enough to distort the signal and they are usually ignored (Kozberg and Hillman, 2016;Ma et al, 2016a).…”
Section: Data Acquisition and Analysis Of Multi-region Neuronal Activitymentioning
confidence: 99%
“…This raises the possibility that the firing pattern of MNTB and other auditory brainstem neurons could be affected by the type of anesthetic used. Recent works in awake animals do not settle this issue, because optical calcium reporter fluorescence techniques were employed in auditory midbrain and cortex (Babola et al, 2018, 2020; Wang et al, 2020a), and when electrophysiology experiments were used, they were performed in the somatosensory cortex of awake mice (Wang et al, 2020b).…”
Section: Introductionmentioning
confidence: 99%