Efferocytosis: An Emerging Therapeutic Strategy for Type 2 Diabetes Mellitus and Diabetes Complications

Efferocytosis, the clearance of apoptotic cells, is a critical process that maintains tissue homeostasis and immune regulation. Defective efferocytosis is linked to the development of chronic inflammatory conditions, including atherosclerosis, neurological disorders, and autoimmune diseases. Moreover, the interplay between autophagy and efferocytosis is crucial for inflammation control, as autophagy enhances the ability of phagocytic cells. Efficient efferocytosis, in turn, regulates autophagic pathways, fostering a balanced cellular environment. Dysregulation of this balance can contribute to the pathogenesis of various disorders. Phytochemicals, bioactive compounds found in plants, have emerged as promising therapeutic agents owing to their diverse pharmacological properties, including antioxidant, anti-inflammatory, and immunomodulatory effects. This review aims to highlight the pivotal role of phytochemicals in enhancing efferocytosis and autophagy and explore their potential in the prevention and treatment of related disorders. This study examines how phytochemicals influence key aspects of efferocytosis, including phagocytic cell activation, macrophage polarization, and autophagy induction. The therapeutic potential of phytochemicals in atherosclerosis and neurological diseases is highlighted, emphasizing their ability to enhance efferocytosis and autophagy and reduce inflammation. This review also discusses innovative approaches, such as nanoformulations and combination therapies to improve the targeting and bioavailability of phytochemicals. Ultimately, this study inspires further research and clinical applications in phytochemical-mediated efferocytosis enhancement for managing chronic inflammatory and autoimmune conditions.

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Machine Learning Identification of TSPAN7 as a Key Target Linking Type 2 Diabetes Mellitus and Colorectal Cancer

Yu,

Yang,

Dong

2024

Preprint

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Background Type 2 Diabetes Mellitus (T2DM) and Colorectal Cancer (CRC) are significant global public health challenges with a notable epidemiological association. This study aims to explore the molecular mechanism behind this epidemiological association. Methods Weighted Gene Co-expression Network Analysis (WGCNA) and differential expression gene (DEG) analysis were conducted to identify shared genes between T2DM and CRC. Machine learning algorithms, including LASSO, Random Forest, and Support Vector Machine (SVM), were employed to identify hub genes. IOBR and clusterProfiler packages were used for immunoinfiltration assessment and enrichment analysis, respectively. Results We identified 27 shared genes between T2DM and CRC, with TSPAN7 emerging as a key hub gene linking the two conditions. TSPAN7 expression was significantly lower in disease groups compared to control groups across multiple cohorts, demonstrating excellent diagnostic accuracy. Enrichment analysis revealed involvement of these genes in various metabolic activities and pathways, including sulfur metabolism, selenium metabolism, renin secretion, pantothenate and CoA biosynthesis, TRP channel regulation, and efferocytosis. Conclusion This study provides new insights into the mechanisms underlying the association between T2DM and CRC by identifying TSPAN7 as a key target. The findings offer theoretical evidence for developing new diagnostic markers and therapeutic strategies for these diseases.

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Efferocytosis: An Emerging Therapeutic Strategy for Type 2 Diabetes Mellitus and Diabetes Complications

Cited by 4 publications

References 150 publications

Mechanism of Efferocytosis in Determining Ischaemic Stroke Resolution—Diving into Microglia/Macrophage Functions and Therapeutic Modality

Mechanism of Efferocytosis in Determining Ischaemic Stroke Resolution—Diving into Microglia/Macrophage Functions and Therapeutic Modality

Phytochemical-mediated efferocytosis and autophagy in inflammation control

Machine Learning Identification of TSPAN7 as a Key Target Linking Type 2 Diabetes Mellitus and Colorectal Cancer

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