Efferocytosis in liver disease

Shi, Hongxue; Moore, Mary P.; Wang, Xiaobo; Tabas, Ira

doi:10.1016/j.jhepr.2023.100960

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2024

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Cited by 5 publications

References 135 publications

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Targeting macrophages with phosphatidylserine-rich liposomes as a potential antigen-specific immunotherapy for type 1 diabetes

Garcia-Loza,

Perna-Barrull,

Aguilera

et al. 2024

Journal of Autoimmunity

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Targeting macrophages with phosphatidylserine-rich liposomes as a potential antigen-specific immunotherapy for type 1 diabetes

Garcia-Loza,

Perna-Barrull,

Aguilera

et al. 2024

Journal of Autoimmunity

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Therapeutic implication of targeting mitochondrial drugs designed for efferocytosis dysfunction

Liu,

Li,

et al. 2024

Journal of Drug Targeting

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Macrophages in necrotic liver lesion repair: opportunities for therapeutical applications

Wang,

Rodrigues,

Chen

et al. 2024

American Journal of Physiology-Cell Physiology

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Healthy livers contain 80% of body resident macrophages known as Kupffer cells. In diseased livers, the number of Kupffer cells usually drops, but is compensated by infiltration of monocyte-derived macrophages, which can differentiate into Kupffer-like cells. Early studies suggest that Kupffer cells play important roles in both promoting liver injury as well as liver regeneration. Yet, the distinction of the functionalities from resident and infiltrating macrophages is not always made. By using more specific macrophage markers and targeted cell depletion and single cell RNA sequencing, recent studies revealed several subsets of monocyte-derived macrophages that play important functions in inducing liver damage and inflammation as well as in liver repair and regeneration. In this review, we discuss the different roles that hepatic macrophages play in promoting necrotic liver lesion resolution and dead cell clearance, as well as the targeting of these cells as potential tools for the development of novel therapies for acute liver failure and acute-on-chronic liver failure.

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Efferocytosis in liver disease

Cited by 5 publications

References 135 publications

Targeting macrophages with phosphatidylserine-rich liposomes as a potential antigen-specific immunotherapy for type 1 diabetes

Targeting macrophages with phosphatidylserine-rich liposomes as a potential antigen-specific immunotherapy for type 1 diabetes

Therapeutic implication of targeting mitochondrial drugs designed for efferocytosis dysfunction

Macrophages in necrotic liver lesion repair: opportunities for therapeutical applications

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