Efferocytosis of vascular cells in cardiovascular disease

Cabrera, Jody Tori O.

doi:10.1016/j.pharmthera.2021.107919

Cited by 22 publications

(6 citation statements)

References 189 publications

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“…In addition, CD47 is expressed on the membrane surface of healthy cells and is recognized by the inhibitory receptor, signal regulatory protein alpha (SIRP𝛼), to inhibit the engulfment by macrophages. [40] The PS level was evaluated by Annexin V staining, and the result indicated that PS-negative neutrophils after isolation maintain more than 90% (Figure S4B,C, Supporting Information), and the VNP-loaded neutrophils could maintain more than 80%, which was consistent with the AM/PI staining result. And then, the expression level of "eat-me" signal (Annexin I) and "do not eat-me" signal (CD47) in neutrophils was measured by RT-PCR.…”

Section: Neutrophils Load Vnp and Maintain Their Activity While Vnp R...supporting

confidence: 75%

Neutrophil‐Mediated Tumor‐Targeting Delivery System of Oncolytic Bacteria Combined with ICB for Melanoma Lung Metastasis Therapy

Liu,

Xin,

et al. 2023

Advanced Science

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Oncolytic bacteria are the most promising tumor target vector. Questions also remain regarding finding a balance between the therapeutic efficacy and safety of oncolytic bacteria. The critical measure of how this balance is maintained is the improvement in tumor colonization. Attenuated Salmonella typhimurium (VNP20009) as the only Salmonella strain to be evaluated in a clinical trial is a potential tumor therapeutic bacterium. A delivery system with controlled release of VNP after being loaded into neutrophils, which significantly increases the tumor‐targeting of VNP and enhances its therapeutic efficacy in a melanoma lung metastasis model is constructed. To improve the synergistic therapeutic effect, a PD1 nanobody is applied to this system (NE(PD1nb)). NE(PD1nb) activate dendritic cells (DCs) differentiation and stimulate the M1‐like differentiation of macrophages, and induce CD4+ T‐cells maturity and cytotoxic CD8+ T‐cells activation through DCs tumor antigen presentation.

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Section: Neutrophils Load Vnp and Maintain Their Activity While Vnp R...supporting

confidence: 75%

Neutrophil‐Mediated Tumor‐Targeting Delivery System of Oncolytic Bacteria Combined with ICB for Melanoma Lung Metastasis Therapy

Liu,

Xin,

et al. 2023

Advanced Science

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“…In the early stages of atherosclerosis, macrophage apoptosis is programmed through the coordinated caspase system, leading to cell death and efferocytosis [ 199 ]. However, when atherosclerosis develops, apoptosis enhances in the macrophage and VSMCs due to increased oxidative stress, the activation of receptors involved in death signaling, the inhibition of survival pathways, and nutrient deprivation [ 200 ].…”

Section: Fibrous Plaque Developmentmentioning

confidence: 99%

Pathophysiology of Atherosclerosis

Jebari-Benslaiman

Galicia-García

Larrea-Sebal

et al. 2022

IJMS

400

208

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Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which is the leading cause of mortality worldwide. Atherosclerosis is initiated by endothelium activation and, followed by a cascade of events (accumulation of lipids, fibrous elements, and calcification), triggers the vessel narrowing and activation of inflammatory pathways. The resultant atheroma plaque, along with these processes, results in cardiovascular complications. This review focuses on the different stages of atherosclerosis development, ranging from endothelial dysfunction to plaque rupture. In addition, the post-transcriptional regulation and modulation of atheroma plaque by microRNAs and lncRNAs, the role of microbiota, and the importance of sex as a crucial risk factor in atherosclerosis are covered here in order to provide a global view of the disease.

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“…3 Dead cells of various types must be efficiently eliminated by specialized or nonspecialized phagocytes. 4 Specialized phagocytes have macrophages and dendritic cells (DCs), which are endemic in tissues and can continuously absorb dead cells and process them very efficiently. Non-specialized phagocytes-epithelial cells, fibroblasts, and other stromal cells-can perform similar phagocytosis, but their absorption is slower and less efficient.…”

Section: Introductionmentioning

confidence: 99%

“…In a healthy organism, cell renewal occurs daily in thousands of cells through programmed death, such as apoptosis and necroptosis 3 . Dead cells of various types must be efficiently eliminated by specialized or non‐specialized phagocytes 4 . Specialized phagocytes have macrophages and dendritic cells (DCs), which are endemic in tissues and can continuously absorb dead cells and process them very efficiently.…”

Section: Introductionmentioning

confidence: 99%

Immunomodulation of wound healing leading to efferocytosis

Zhao,

Li,

Mao

et al. 2024

Smart Medicine

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Effectively eliminating apoptotic cells is precisely controlled by a variety of signaling molecules and a phagocytic effect known as efferocytosis. Abnormalities in efferocytosis may bring about the development of chronic conditions, including angiocardiopathy, chronic inflammatory diseases and autoimmune diseases. During wound healing, failure of efferocytosis leads to the collection of apoptosis, the release of necrotic material and chronic wounds that are difficult to heal. In addition to the traditional phagocytes‐macrophages, other important cell species including dendritic cells, neutrophils, vascular endothelial cells, fibroblasts and keratinocytes contribute to wounding healing. This review summarizes how efferocytosis‐mediated immunomodulation plays a repair‐promoting role in wound healing, providing new insights for patients suffering from various cutaneous wounds.

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Efferocytosis of vascular cells in cardiovascular disease

Cited by 22 publications

References 189 publications

Neutrophil‐Mediated Tumor‐Targeting Delivery System of Oncolytic Bacteria Combined with ICB for Melanoma Lung Metastasis Therapy

Neutrophil‐Mediated Tumor‐Targeting Delivery System of Oncolytic Bacteria Combined with ICB for Melanoma Lung Metastasis Therapy

Pathophysiology of Atherosclerosis

Immunomodulation of wound healing leading to efferocytosis

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