Effet analgésique de la crème Emla®, du saccharose et de leur association pour les injections sous-cutanées chez le nouveau-né prématuré : étude prospective de 265 injections

Mucignat, V; Ducrocq, S.; Lebas, François; Mochel, Fanny; Baudon, J; Gold, F.

doi:10.1016/j.arcped.2004.03.028

Cited by 35 publications

(6 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A sweet-tasting solution placed in an infant’s mouth can reduce responses to painful stimuli; sweet taste perception mediates both endogenous opioid and nonopioid systems to block pain afferents (34). LCS, such as aspartame, mimic the time course and the magnitude of the increased calming (35, 36) and mouthing and hand-to-mouth contact effects (35) of sucrose. Given that the administration of sucrose by direct stomach loading was ineffective (37), it may be that afferent signals from the mouth, rather than gastric or metabolic changes, are responsible for the analgesic properties of sweet tastes.…”

Section: Responses To Sweet Taste During Developmentmentioning

confidence: 99%

Sweetness and Food Preference

Drewnowski

Mennella

Johnson

et al. 2012

The Journal of Nutrition

265

148

View full text Add to dashboard Cite

Human desire for sweet taste spans all ages, races, and cultures. Throughout evolution, sweetness has had a role in human nutrition, helping to orient feeding behavior toward foods providing both energy and essential nutrients. Infants and young children in particular base many of their food choices on familiarity and sweet taste. The low cost and ready availability of energy-containing sweeteners in the food supply has led to concerns that the rising consumption of added sugars is the driving force behind the obesity epidemic. Low-calorie sweeteners are one option for maintaining sweet taste while reducing the energy content of children’s diets. However, their use has led to further concerns that dissociating sweetness from energy may disrupt the balance between taste response, appetite, and consumption patterns, especially during development. Further studies, preferably based on longitudinal cohorts, are needed to clarify the developmental trajectory of taste responses to low-calorie sweeteners and their potential impact on the diet quality of children and youth.

show abstract

Section: Responses To Sweet Taste During Developmentmentioning

confidence: 99%

Sweetness and Food Preference

Drewnowski

Mennella

Johnson

et al. 2012

The Journal of Nutrition

265

148

View full text Add to dashboard Cite

show abstract

“…However, the difference between groups was not statistically significant. In other studies, it was stated that respiratory rate, heart rate, blood pressure and oxygen saturation were not significant in pain analysis before and after the procedure ( 10 , 19 ).…”

Section: Discussionmentioning

confidence: 87%

“…For the pharmacological treatment of pain in newborns, opioid and non-opioid analgesic, sedatives and local anaesthetics are used ( 8 ). EMLA application, a pharmacological method that is easy to apply in the elimination and reduction of pain in newborns, is safely and effectively used for newborns undergoing intravenous (IV) vascular catheterisation, IV bloodletting, lumbar puncture, central venous catheterisation, circumcision and intramuscular (IM) injection ( 9 , 10 ). In Unaldis ( 11 ) study, it was determined that EMLA cream was effective in pain reduction during painful procedures on newborns.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Instrumental Touching on Infant Pain Perception and the Effects of Eutectic Mixture of Local Anesthetics (EMLA) on the Reduction of Pain

et al. 2015

View full text Add to dashboard Cite

Background:Premature infants, who have to spend the first week of their lives in neonatal intensive care units (NICUs), experience pain and stress in numerous cases, and they are exposed to many invasive interventions. The studies have shown that uncontrolled pain experienced during early life has negative and long-term side effects, such as distress, and such experiences negatively affect the development of the central nervous systemObjectives:The purpose of the study was to examine the effects of touching on infant pain perception and the effects of eutectic mixture of local anesthetic (EMLA) on the reduction of pain.Patients and Methods:Data for the study were collected between March and August 2012 from the neonatal clinic of a university hospital located in eastern Turkey. The population of the study consisted of premature infants who were undergoing treatment, completed the first month and who were approved for Hepatitis B vaccine. The study consisted of two experimental groups and one control group. Information forms, intervention follow-up forms, and Premature Infant Pain Profile (PIPP) were used to collect the data. EMLA cream was applied on the vastus lateralis muscles of the first experimental group before the vaccination. The second experimental group was vaccinated by imitation (placebo), without a needle tip or medicine. Vaccination was carried out using instrumental touch in this group. A routine vaccination was applied in the control group.Results:Mean pain scores of the group to which EMLA was applied were lower in a statistically significant way (P < 0.05) compared to the pain scores of the other groups. Moreover, it was determined that even though invasive intervention was not applied to the newborns, the touching caused them to feel pain just as in the placebo group (P < 0.005).Conclusions:The results demonstrated that EMLA was an effective method for reducing pain in premature newborns, and the use of instrumental touch for invasive intervention stimulated the pain perception in the newborns.

show abstract

“…In addition, despite the prolific research conducted to date, repeated doses of sweet solutions over prolonged periods have only been investigated in a small number of studies. [72][73][74][75] Although these studies showed ongoing effectiveness of sucrose over weeks to months of use, further research in this area, especially with the aim of exploring if consistently reducing procedural pain over prolonged hospitalizations ameliorates negative sequela of untreated pain for preterm and high-risk neonates, will add valuable information to the science of neonatal pain management.…”

Section: Facilitators and Barriers To Implementationmentioning

confidence: 97%

Prevention and management of pain and stress in the neonate

Harrison¹,

Bueno²,

Reszel³

2015

RRN

View full text Add to dashboard Cite

Neonates have blood work for newborn screening in their first days of life, and preterm and sick hospitalized infants often require repeated invasive needle-related procedures over the duration of their hospitalization. Reducing newborn infants' pain during such painful procedures is important and may reduce the risk of negative sequela of poorly treated procedural pain. High-quality synthesized evidence demonstrates analgesic effects of three pain management strategies: breastfeeding; skin-to-skin care, also referred to as kangaroo care; and small amounts of sweet solutions. These strategies are simple to use, easily accessible, and extremely cost-effective. Published neonatal and infant pain guidelines include recommendations to use these strategies prior to and during painful procedures. Yet, despite the robust evidence and pain management recommendations in guidelines and national and international organizations, knowledge has not been translated into consistent normalized care in diverse maternal newborn, neonatal, and pediatric settings where painful procedures for infants take place. There may be knowledge gaps or barriers impeding consistent use of effective pain management for newborn infants. This paper will present a brief review of methods used to assess neonatal pain, followed by a summary of the evidence supporting breastfeeding, skin-to-skin care, and sweet solutions for procedural pain reduction with a discussion about barriers and facilitators to using these strategies in the clinical setting. Finally, a review of recommendations included in current neonatal pain guidelines will be presented.

show abstract

Effet analgésique de la crème Emla®, du saccharose et de leur association pour les injections sous-cutanées chez le nouveau-né prématuré : étude prospective de 265 injections

Cited by 35 publications

References 27 publications

Sweetness and Food Preference

Sweetness and Food Preference

The Effects of Instrumental Touching on Infant Pain Perception and the Effects of Eutectic Mixture of Local Anesthetics (EMLA) on the Reduction of Pain

Prevention and management of pain and stress in the neonate

Contact Info

Product

Resources

About