Effets Antihypertensifs Des Extraits Aqueux Et Éthanolique Des Graines Fermentées De Parkia Biglobosa (Mimosaceae) Chez Les Rats

Ouolouho, Coulibaly Seydou; Abou, Ouattara; Karamoko, Ouattara; Coulibaly, Adama

doi:10.19044/esj.2017.v13n36p162

Cited by 6 publications

(5 citation statements)

References 6 publications

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“…This duration would be much higher for nicardipine. These effects are similar to others that have involved reference products in the evaluation of hypotensive effects of medicinal plants (Yang et al, 2000;Leonetti et al, 2002;Yomalan et al, 2008;Traore et al, 2008;Coulibaly et al, 2017;Okemy et al, 2020).…”

Section: Discussionsupporting

confidence: 86%

Hydrocotyle bonariensis Comm ex Lamm (Araliaceae) leaves effects on rabbits blood pressure and electrocardiogram

Komla,

Tcha,

Aklesso

et al. 2023

Afr. J. Pharm. Pharmacol.

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Hydrocotyle bonariensis Comm ex Lamm (Araliaceae) is traditionally used to treat various pathologies like hypertension. This work aims to evaluate the impact of hydro-ethanolic extract of its leaves on the blood pressure and cardiac activity of rabbits, and then to compare its hypotensive effect to conventional hypotensives. Intravenous injection of the hydro-ethanolic leaf extract (10; 20; 40; 80 and 160 mg /kg body weight) of H. bonariensis induced a significant decrease in systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean blood pressure (MBP) in rabbits. Injection of same doses induced at 80 and 160 mg /kg on the rabbit's ECG a decrease in P wave amplitude and heart rate but caused a rise in RR interval. Comparison of the hypotensive effect of 40 mg/kg extract with the effects of 1.5 mg/kg propranolol, 0.1 mg/kg nicardipine and 1.5 mg/kg furosemide in rabbits shows that there is insignificant variation between the hypotensive effect of the extract and the hypotensive effects of these products at the doses administered in rabbits. These results confirm the hypotensive effect of H. bonariensis leaf extract, thus justifying its utilization managing high blood pressure traditionally.

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Section: Discussionsupporting

confidence: 86%

Hydrocotyle bonariensis Comm ex Lamm (Araliaceae) leaves effects on rabbits blood pressure and electrocardiogram

Komla,

Tcha,

Aklesso

et al. 2023

Afr. J. Pharm. Pharmacol.

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“…En plus de sa fonction vasodilatatrice, ce condiment a un potentiel antioxydant. En effet, des études menées par Coulibaly et al (2017) et Cissé et al (2021 ont mis en évidence la présence de groupe de Chaque barre représente la moyenne ± ESM, n = 4. ***P < 0,05 ; différence significative par rapport au lot témoin.…”

Section: Discussionunclassified

“…C'est une espèce de la famille Mimosaceae. Des études ont révélé l'effet antihypertenseur des extraits aqueux des écorces de néré (Yomalan et al, 2008) et des extraits aqueux et éthanolique des graines fermentées de P. biglobosa (Coulibaly et al, 2017). Les graines fermentées de néré sont communément appelées soumara en Côte d'Ivoire.…”

Section: Introductionunclassified

Effets des extraits aqueux et éthanolique des graines fermentées de Parkia biglobosa (Mimosaceae) sur quelques marqueurs du stress oxydatif chez les rats rendus hypertendus

Coulibaly¹,

Koné²,

Abou³

2023

Int. J. Bio. Chem. Sci

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Les graines fermentées de néré sont utilisées en médecine traditionnelle pour traiter l’hypertension artérielle qui est une importante cause de décès dans le monde. Cette pathologie entraîne aussi le stress oxydatif. C’est la raison pour laquelle, cette étude a été menée pour évaluer l’effet antioxydant des extraits aqueux et hydro-éthanolique de ce condiment chez les rats rendus hypertendus par injection de l’adrénaline à la dose de 1,46.10-3mg/kg pc. L’administration par gavage des extraits avec les doses allant de 1000 à 2000 mg/kg pc et de la Nifédipine à la dose de 10 à 20 mg/kg pc pendant 6 jours a provoqué une augmentation significative de l’activité des enzymes anti-oxydantes (SOD et catalase) et de monoxyde d’azote (NO), comparativement aux rats rendus hypertendus non traité (recevant essentiellement de l’eau), chez lesquels, il a été observé une baisse significative de l’activité de ces enzymes et de NO. En revanche, il a été constaté une augmentation significative des sous-produits de la peroxydation lipidique (malonaldéhyde) chez les rats rendus hypertendus non traité et une baisse significative chez les rats rendus hypertendus et traités. Au total, les graines fermentées de néré possèdent un important potentiel antioxydant. Fermented néré seeds are used in traditional medicine to treat high blood pressure which is a leading cause of death worldwide. This pathology also causes oxidative stress. This is the reason why this study was conducted to evaluate the antioxidant effect of aqueous and hydro-ethanolic extracts of this condiment in rats rendered hypertensive by injection of adrenaline at a dose of 1.46.10-3mg/ kg bw. Administration by gavage of extracts with doses ranging from 1000 to 2000 mg/kg bw and nifedipine at a dose of 10 to 20 mg/kg bw for 6 days caused a significant increase in the activity of anti- oxidants (SOD and catalase) and nitric oxide (NO), compared to untreated hypertensive rats (mainly receiving water), in which a significant drop in the activity of these enzymes was observed and of NO. In contrast, there was a significant increase in lipid peroxidation by-products (malonaldehyde) in rats rendered hypertensive untreated and a significant decrease in rats rendered hypertensive and treated. Overall, fermented néré seeds have significant antioxidant potential.

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“…Aqueous extracts contain as many secondary metabolites as the alcoholic extracts commonly used in laboratories for the confirmation of empirical uses. It's about polyphenols, flavonoids, tannins quinones, saponins, alkaloids, sterols and polyterpenes wich are very abundant in aqeous extracts that organic extratcs 16,17 . Experimentally, the pharmacological effects of these metabolites have been scientifically proven.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical screening, mineral analysis and evaluation of the diuretic effect of aqueous extract of Pericopsis laxiflora from male Sprague Dawley rats

Doukourou

Kamou

Bamba

et al. 2021

J. Drug Delivery Ther.

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Pericopsis laxiflora is among the medicinal plants used by the traditional practitioner in the treatment of many diseases. However, data on its diuretic power are lacking. Moreover, the effect of the preparation of traditional galenic formulations on the composition of phytocompounds and essential minerals and metals is unknown. The aim of this study was to show the effect of treatment on the phytocompounds and minerals composition and to evaluate diuretic effect of Pericopsis laxiflora aqueous axtracts. The tube characterization reactions revealed flavonoids, sterols, terpenes, catechin tannins polyphenols and saponins in aqueous extracts. Gallic tannins and quinones are absent, All compounds were generally present in same proportions in two aqueous extracts. Chemical analysis of all aqueous extracts by atomic absorption spectrometry (AAS) showed effect of model extraction on minerals. Copper (0.3116 mg / 100g), magnesium (260.7 mg /100 g), selenium (0.00904 mg /100 g), zinc (4.52 mg /100 g), manganese (75.029 mg /100g) are more concentrated in maceration than a decoction. For decoction of same plant, the situation is reversed with sodium (58.6mg /100g), calcium (12670 mg/100g), iron (18.51mg/100g) and potassium (2781 mg /100g). For pharmacological investigation, 32 rats Sprague Dawley male weighing 385-433g are isolated each in metabolic cages from 6 pm to 8am and treated with 100mg/kg of Pericopsis laxiflora aqueous extracts. From 8am to 2pm the animals received only tap water in metabolic cages. The volumes of water intake and urine were not significantly different in the two groups (treated and untreated).The diuretic effect was not observed with 100mg/kg (b/w) . In addition polyphenols, flavonoids, saponins and minerals such as potassium, magnesium and selenium are indicators of the vasodilatory and cardioprotective functions of Pericopis laxiflora aqueous extracts. The prescription of these extracts in traditional medicine must take into account the toxicity of the plant associated with a calcium and manganese content. Keywords: Pericopsis laxiflora, dueresis, decocted extract, macerated extract, minerals, Rats Sprague Daweley

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Effets Antihypertensifs Des Extraits Aqueux Et Éthanolique Des Graines Fermentées De Parkia Biglobosa (Mimosaceae) Chez Les Rats

Cited by 6 publications

References 6 publications

Hydrocotyle bonariensis Comm ex Lamm (Araliaceae) leaves effects on rabbits blood pressure and electrocardiogram

Hydrocotyle bonariensis Comm ex Lamm (Araliaceae) leaves effects on rabbits blood pressure and electrocardiogram

Effets des extraits aqueux et éthanolique des graines fermentées de Parkia biglobosa (Mimosaceae) sur quelques marqueurs du stress oxydatif chez les rats rendus hypertendus

Phytochemical screening, mineral analysis and evaluation of the diuretic effect of aqueous extract of Pericopsis laxiflora from male Sprague Dawley rats

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