Effets de la mitomycine sur l'incorporation de la thymidine tritiée dans les embryons d'amphibiens au stade morula

Bieliavsky, Nicolas

doi:10.1016/0014-4827(63)90109-5

Cited by 8 publications

(1 citation statement)

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“…The mitomycins also are instrumental in the stimulation of chromosomal exchanges and crossing-over (SHAW and CoHEN, 1965;SuzuKI, 1965) and for genetic recombination (lrJIMA and HAGAWARA, 1960;YuKI, 1962;HoLLIDAY, 1964), and in its inhibition . They cause fragmentation of chromosomes and other cell structures (BACH and MAGEE, 1962;BIELIAVSKY, 1963; CoHEN and SHAW, 1964;KERSTEN and THEMANN, 1962; 218 W. SzYBALSKI and V. N. lYER: KIMURA, 1963;KOSAKA, 1964;KURODA and FURUYAMA, 1963; LAPIS and BERN-HARD, 1965;MERZ, 1961; SHATKIN et al, 196Z; TRUHAUT and DEYSSON, 1960) resulting in inhibition of the development of pleurodele embryos blocked in the morula stage (BIELIAVSKY, 1963), giant cell formation (SHATKIN etal., 1962), and other abnormal growth as e.g., filament formation, an effect already mentioned.Mitomycin was also found to inhibit postirradiation repair of fragmented chromosomes (MATSUURA et al, 196Z, 1963;IWABUCHI et al, 1966).The mitomycins were found to influence the action of the polymerases, including stimulation of DNA polymerase activity in mammalian cells (BACH and MAGEE, 196Z; MAGEE and MILLER, 196Z) but not in bacteria (NAKATA et al, 196Z; SEKIGUCHI and TAKAGI, 1960a) and 60 to 75% impairment WEISS-BACH, 1964, 1965) or little impairment (TAKAGI, 1963;KONTANI, 1964) of the in vitro priming capacity of DNA for the DNA polymerase but not for the DNAdependent RNA polymerase. No changes in RNA base composition were detected in mitomycin-treated Ehrlich ascites cell (AKAMATSU et al, 1963).…”

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Antibiotics

1967

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AII rights, especially that of tnmslation into foreign languages, reserved. It is also forbidden to reproduce this book, either whole DedicationFor most areas of scientific pursuit, there is usually that rare investigator who has the imagination to conceive ideas, who has faith in his visions, and who has the ability to critically test his concepts in the laboratory. Almost invariably, this scientist also inspires younger men to enthusiastically enter into his research program. To him should go the accolades and the recognitions of the esteem in which he is held. As only a small part of this esteem, we wish to dedicate these books to Professor SELMAN A. W AKSMAN in appreciation of his leadership and contributions in all facets of antibiotic research. PrefaceThe idea for publishing these books on the mechanism of action and on the biosynthesis of antibiotics was born of frustration in our attempts to keep abreast of the literature. Gone were the years when we were able to keep a bibliography on antibiotics and feel confident that we could find everything that was being published on this subject. These fields of investigation were moving forward so rapidly and were encompassing so wide a range of specialized areas in microbiology and chemistry that it was almost impossible to keep abreast of developments. In our naivete and enthusiasm, however, we were unaware that we were toying with an idea that might enmesh us, that we were creating an entity with a life of its own, that we were letting loose a Golom who instead of being our servant would be our master.That we set up ideals for these books is obvious; they would be current guides to developments and information in the areas of mechanism of action and biosynthesis of antibiotics. For almost every subject, we wished to enlist the aid of an investigator who himself had played a part in determining the nature of the phenomena that were being discussed. One concept for the books was that they include only antibiotics for which a definitive, well-documented mechanism of action or biosynthetic pathway was known. Yet, such an approach would not entirely serve the purpose we projected, for it would not encompass all of the information available in these fields of antibiotic investigations and blind searches for the original literature would still have to be made. We therefore chose to include any and all antibiotics about which some pertinent information had been published. It was obvious even at the start that such a compilation, integration, and analysis of information could never be complete unless scientific investigations ceased at the moment the last manuscript was submitted-an end that was neither desirable nor possible. An addendum was therefore included at the end of the volume and left open for the addition of new information until the last pages of the regular articles had been printed.The original concept has also been further expanded as the authors of several papers found it advisable to elaborate on their subject. Some of the articles included discussions...

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confidence: 99%