Effets indésirables des inhibiteurs calciques utilisés dans le cadre de la tocolyse

Clouqueur, É.; Gautier, S.; Vaast, P.; Coulon, C.; Deruelle, Philippe; Subtil, D.; Debarge, V.

doi:10.1016/j.jgyn.2014.12.012

Cited by 8 publications

(3 citation statements)

References 37 publications

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“…Basically, tocolytic drugs are the main option for the treatment of preterm birth. Unfortunately, they have been frequently associated with low efficacy and adverse reactions (Clouqueur et al, 2015;Elliott, Morrison, & Bofill, 2016;Guden et al, 2016). For that reason, the development of new drugs and/or the discovery of medicinal plants for the treatment of PTB is an area of growing interest.…”

Section: Discussionmentioning

confidence: 99%

In vitro effects of citral on the human myometrium: Potential adjunct therapy to prevent preterm births

Muñoz-Pérez

Ortiz

Salas-Casa

et al. 2021

Birth Defects Research

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Background: Premature infants contribute to infant morbidity and mortality especially in low resource settings. Information on tocolytic and/or antiinflammatory effects of several plant extracts, such as citral, could help prevent preterm birth cases and reduce the number of preterm infants. The aim of this study was to evaluate the in vitro tocolytic and anti-inflammatory effect of citral on myometrial tissues of the human uterus.Methods: Myometrial samples from uteri obtained after hysterectomy were used in functional tests to evaluate the inhibitory effect of citral on PGF-2α induced contractions. The intracellular cyclic adenosine monophosphate (cAMP) levels generated in response to citral in human myometrial homogenates were measured by ELISAs. Forskolin was used as a positive control. The anti-inflammatory effect of citral was determined through the measurement of two pro-inflammatory cytokines, tumor necrosis factor-α (TNFα) and interleukin (IL)-1β, and the anti-inflammatory cytokine IL-10, in human myometrial explants stimulated with lipopolysaccharide (LPS).Results: Citral was able to induce a significant inhibition of PGF-2α induced contractions at the highest concentration level (p < .05). Citral caused a concentration-dependent increase in myometrial cAMP levels (p < .05) and a concentration-dependent decrease in LPS-induced TNFα and IL-1β production, while IL-10 production increased significantly (p < .05). The antiinflammatory and tocolytic effects induced by citral could be associated with an increase in cAMP levels in human myometrial samples. Conclusion:These properties place citral as a potentially safe and effective adjuvant agent in preterm birth cases, an obstetric and gynecological problem that requires urgent attention.

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Section: Discussionmentioning

confidence: 99%

In vitro effects of citral on the human myometrium: Potential adjunct therapy to prevent preterm births

Muñoz-Pérez

Ortiz

Salas-Casa

et al. 2021

Birth Defects Research

View full text Add to dashboard Cite

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“…Also in 1975, a third class of L‐type CCBs was discovered, the benzothiazepine class, for example, diltiazem . CCBs are also known as slow channel blockers, calcium entry blockers, and calcium antagonists .…”

Section: Channel Blockers As Cardiovascular Agents: Design and Develomentioning

confidence: 99%

“…Nowadays, calcium channels blockers widely discussed as anticancer agents (T‐type CCBs) , as drugs targeting in central nervous system (CNS) disorders (for example, epilepsy) (L‐type CCBs) , agents for the treatment of certain types of pain (N‐type CCBs) , and so on; their tocolytic effect also is widely applicable in obstetrics . In addition, calcium channels are emerging as targets for novel therapeutic indications .…”

Section: Introductionmentioning

confidence: 99%