Effetti di un nuovo preparato farmaceutico sulla guarigione di lesioni aftosiche in pazienti di età pediatrica

Sfondrini, Maria Francesca; Fraticelli, D; Barbati, M.; Scribante, Andrea; Gandini, Paola

doi:10.1016/j.cadmos.2011.11.008

Cited by 5 publications

(5 citation statements)

References 14 publications

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“…Furthermore, panel C shows that after 6 months of storage of the prepared powder (at room temperature, in the dark) the loaded RSV remains in the amorphous form. This is probably due to the efficacy of PVP K90 in preventing drug crystallization by enhancing the physical stability of the amorphous form [46,47]. These results are particularly interesting and satisfactory, as well as being perfectly coherent with the observed enhancement of RSV solubility for the RSV-B formulation.…”

Section: Characterization Of Rsv-b Powder and Mini-tabletssupporting

confidence: 64%

“…Furthermore, it increases the physical stability of amorphous drug forms by preventing crystallization. Additionally, PVP K90 is often used to prepare mucosal DDSs due to its mucoadhesive properties [46,47]. To promote RSV solubilization into the buccal environment, PEG 200 was chosen as the secondary polymer.…”

Section: Preparation and Characterization Of Rsv-loaded Mini-tablets By Spray Drying Techniquementioning

confidence: 99%

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Improvement of Resveratrol Permeation through Sublingual Mucosa: Chemical Permeation Enhancers versus Spray Drying Technique to Obtain Fast-Disintegrating Sublingual Mini-Tablets

et al. 2021

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Resveratrol (RSV) is a natural polyphenol with several interesting broad-spectrum pharmacological properties. However, it is characterized by poor oral bioavailability, extensive first-pass effect metabolism and low stability. Indeed, RSV could benefit from the advantage of the sublingual route of administration. In this view, RSV attitudes to crossing the porcine sublingual mucosa were evaluated and promoted both by six different chemical permeation enhancers (CPEs) as well as by preparing four innovative fast-disintegrating sublingual mini-tablets by spray drying followed by direct compression. Since RSV by itself exhibits a low permeation aptitude, this could be significantly enhanced by the use of CPEs as well as by embedding RSV in a spray-dried powder to be compressed in order to prepare fast-disintegrating mini-tablets. The most promising observed CPEs (menthol, lysine and urea) were then inserted into the most promising spray-dried excipients’ compositions (RSV-B and RSV-C), thus preparing CPE-loaded mini-tablets. However, this procedure leads to unsatisfactory results which preclude the possibility of merging the two proposed approaches. Finally, the best spray-dried composition (RSV-B) was further evaluated by SEM, FTIR, XRD and disintegration as well as dissolution behavior to prove its effectiveness as a sublingual fast-disintegrating formulation.

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Section: Characterization Of Rsv-b Powder and Mini-tabletssupporting

confidence: 64%

Section: Preparation and Characterization Of Rsv-loaded Mini-tablets By Spray Drying Techniquementioning

confidence: 99%

Improvement of Resveratrol Permeation through Sublingual Mucosa: Chemical Permeation Enhancers versus Spray Drying Technique to Obtain Fast-Disintegrating Sublingual Mini-Tablets

et al. 2021

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“…PVP-K90 possesses strong chemical bonding affinity with mucins and high chemical and biological inertness. Therefore, PVP has been used in order to achieve an intimate and prolonged contact with oral mucosa, a crucial requirement for an oral Adhesive Drug Delivery System [52]. Flexibility and softness characteristics have been conferred to the films by the introduction of moisturizing agents and plasticizers [53]; in particular, Sorbitol and Propylene Glycol are chosen for their ability to retain water within the film and for their inhibitory activity on bacterial growth, especially when they are in association [54].…”

Section: Resultsmentioning

confidence: 99%

Enhanced In Situ Availability of Aphanizomenon Flos-Aquae Constituents Entrapped in Buccal Films for the Treatment of Oxidative Stress-Related Oral Diseases: Biomechanical Characterization and In Vitro/Ex Vivo Evaluation

Murgia

Seidita

et al. 2019

Pharmaceutics

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In recent years, the key role of oxidative stress in pathogenesis of oral diseases has been emphasized and the use of antioxidant agents has been encouraged. Aphanizomenon flos-aquae (AFA) is a unicellular blue-green alga with antioxidant and anti-inflammatory properties. The aim of this study was the formulation and characterization of mucoadhesive thin layer films loaded with AFA, finalized to the treatment of oxidative stress (OS)-related oral diseases. First, to enhance the bioavailability of AFA constituents, the raw food grade material was appropriately treated by a high frequency homogenization able to disrupt cell walls. Thus, Eudragit® E100-based buccal films were produced by the solvent casting method, containing 7% and 18% of AFA. The films, characterized by uniformity in thickness, weight, and drug content, showed low swelling degree, good muco-adhesiveness and controlled drug release. The mechanical tests showed elastic moduli of films of almost 5 MPa that is well-suitable for human buccal applications without discomfort, besides biaxial tests highlighted a marked material isotropy. Permeation studies through porcine mucosae demonstrated the ability of films to promote AFA penetration in the tissues, and when sublingually administered, they produced a drug flux up to six-fold higher than an AFA solution. The new formulations represent an interesting alternative for the development of cosmetics and nutraceuticals with a functional appeal containing plant extracts.

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“…Additionally, the introduction of polyvinylpyrrolidone (PVP) is crucial in order to obtain an effective adhesive drug delivery system. Thanks to its ability to form additional bonds with the mucins and its high biological and chemical inertia, PVP is able to ensure a prolonged an intimate contact with the buccal mucosa [37,38]. Moreover, the addition of plasticizing agents is needed to obtain a flexible and soft film that could prove comfortable and adaptable to the site of application.…”

Section: Design Development and Optimization Of Rop-loaded Filmmentioning

confidence: 99%

Amorphous Ropinirole-Loaded Mucoadhesive Buccal Film: A Potential Patient-Friendly Tool to Improve Drug Pharmacokinetic Profile and Effectiveness

Prima

Campisi

2020

JPM

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Nowadays the therapeutic strategies to manage Parkinson’s Disease are merely symptomatic and consist of administering L-DOPA and/or dopamine receptor agonists. Among these, Ropinirole (ROP) is a widely orally-administered molecule, although it is extensively susceptible to hepatic metabolism. Since literature reports the buccal mucosa as a potentially useful route to ROP administration, the development of novel, effective, and comfortable oromucosal formulations should prove desirable in order to both enhance the therapeutic efficacy of the drug and allow a personalized therapeutic strategy able to meet the patient’s needs. The results of the proposed ROP film as a new dosage form show that it is flexible; uniform; and characterized by suitable surface pH; good mucoadhesiveness; low swelling degree; and fast, complete drug release. Moreover, after ex vivo evaluation on a film having an area of 0.282 cm2 and dose of 2.29 mg, the results of drug flux through the buccal mucosa are closely comparable to the amount of ROP that reaches the bloodstream at the steady-state condition after ROP-PR 4 mg oral administration, calculated according to the literature (0.237 mg/cm2·h−1 vs. 0.243 mg/h, respectively). Moreover, drug flux and ROP dose could be accurately modulated time-by-time depending on the patient’s need, by varying the administered disk area. In addition, the proposed ROP film displays no lag time, producing an immediate drug input in the bloodstream, which could result in a prompt therapeutic response. These findings make ROP film a potentially comfortable and patient-friendly formulation, and a promising candidate for further clinical trials.

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Effetti di un nuovo preparato farmaceutico sulla guarigione di lesioni aftosiche in pazienti di età pediatrica

Cited by 5 publications

References 14 publications

Improvement of Resveratrol Permeation through Sublingual Mucosa: Chemical Permeation Enhancers versus Spray Drying Technique to Obtain Fast-Disintegrating Sublingual Mini-Tablets

Improvement of Resveratrol Permeation through Sublingual Mucosa: Chemical Permeation Enhancers versus Spray Drying Technique to Obtain Fast-Disintegrating Sublingual Mini-Tablets

Enhanced In Situ Availability of Aphanizomenon Flos-Aquae Constituents Entrapped in Buccal Films for the Treatment of Oxidative Stress-Related Oral Diseases: Biomechanical Characterization and In Vitro/Ex Vivo Evaluation

Amorphous Ropinirole-Loaded Mucoadhesive Buccal Film: A Potential Patient-Friendly Tool to Improve Drug Pharmacokinetic Profile and Effectiveness

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